Coronary Hemodynamics by Coronary Angiography (ESCARGOT)

Study for developing techniques to evaluate coronary artery hemodynamic profiles by conventional angiography without more dedicated measuring devices.

* Methods: Compare TIMI frame count, coronary clearance frame count in baseline/hyperemic coronary angiography with FFR, CFR, IMR and derive correlation, receiver-operating characteristic curve to find new tools estimating coronary hemodynamics by conventional angiography only. A TIMI frame count is measured by counting the angiographic image cine frames during a head of radiocontrast column runs from the entry of left anterior descending artery (LAD) to the distal end. A coronary clearance frame count is measured by counting the angiographic image cine frames during a tail of radiocontrast column runs from the entry of LAD to the distal end. Baseline angiography is performed without any stimulation and hyperemic angiography is performed after intracoronary injection of adenosine 300ug or nicorandiol 2mg. Inclusion criteria Patient who underwent physiologic study using a pressure wire for intermediate coronary lesion after coronary angiography Exclusion criteria ST elevation myocardial infarction Cardiogenic shock Congestive heart failure with pulmonary edema LVEF < 30% Previous history of coronary revascularization Chronic total occlusion 3 vessel disease Target lesion at distal segments or branches

coronary artery disease, Index of microcirculatory resistance, TIMI frame count, Fractional flow reserve, Coronary flow reserve

Inclusion criteria Patient who underwent physiologic study using a pressure wire for intermediate coronary lesion after coronary angiography Exclusion criteria ST elevation myocardial infarction Cardiogenic shock Congestive heart failure with pulmonary edema LVEF < 30% Previous history of coronary revascularization Chronic total occlusion 3 vessel disease Target lesion at distal segments or branches