Cost- Effectiveness and Quality of Life Assessment in Major Depression Disorder
Depression
About this trial
This is an interventional treatment trial for Depression focused on measuring Cost effectiveness, Unipolar Depression, Major Depression Disorder, Quality of life disorder
Eligibility Criteria
Inclusion Criteria:
- ages between 18 and 65;
- current acute unipolar depression episode;
- total capacity to understand and respond to self-applied instruments;
- the presence of symptoms in the last 30 days;
- abstinence for at least 30 days for drug addicts
Exclusion Criteria:
- presence of Organic Brain Syndrome (OBS);
- pregnancy or lactation;
- criteria for psychiatric hospitalization.
Sites / Locations
Arms of the Study
Arm 1
Experimental
Sertraline
Group Started: sertraline (50mg-200mg) Subjects evaluated for responsiveness every 2 weeks. Responsive to treatment patients remain in the same step. Max. step duration of 8 weeks. First step: Monotherapy with sertraline (50-200mg). Non responsive patients: 2nd step. Second step: Sertraline 200mg + lithium (900mg-1500mg) Non responsive patients: 3rd step. Third step: Nortriptyline 100mg Non responsive patients: 4th step. Fourth step: Nortriptyline 100mg + lithium (900mg-1500mg) Non responsive patients : 5th step Fifth step : Nortriptyline 100mg + sertraline 200mg Non responsive patients sixth step: Nortriptyline 100mg + sertraline 200mg + Lithium ( 900mg- 1500mg)