Countermeasures to Reduce Sensorimotor Impairment and Space Motion Sickness Resulting From Altered Gravity Levels
Vestibular
About this trial
This is an interventional basic science trial for Vestibular
Eligibility Criteria
Inclusion Criteria:
- Subjects must be in general good health
Exclusion Criteria:
- Anyone who is not generally in good general health does not qualify
- Cardiovascular disease
- Severe diabetes
- Respiratory condition (e.g. asthma or emphysema)
- Narrow angle glaucoma
- Prostatic hypertrophy
- Gastrointestinal disorders
Sites / Locations
- Massachusetts Eye and Ear Infirmary
Arms of the Study
Arm 1
Arm 2
Arm 3
Arm 4
Arm 5
Arm 6
Arm 7
Arm 8
Arm 9
Arm 10
Experimental
Placebo Comparator
Experimental
Experimental
Experimental
Placebo Comparator
Experimental
Experimental
Experimental
Experimental
Tilt perception, Training, placebo
Tilt perception, No training, placebo
Tilt perception, Training, promethazine
Tilt perception,No training,promethazine
Manual Control, Training, placebo
Manual Control, No training, placebo
Manual Control, Training, promethazine
Manual Control,No training,promethazine
Perceptual thresholds,drug then placebo
Perceptual thresholds,placebo then drug
placebo
subject does test with no hypergravity training and placebo drug only
promethazine 25 mg, one time 120 minutes prior to experiment
promethazine 25 mg, one time 120 minutes prior to experiment. No hypergravity training
placebo
subject does test with no hyper gravity training and placebo drug only
promethazine 25 mg, one time 120 minutes prior to experiment
promethazine 25 mg, one time 120 minutes prior to experiment
Subjects undergo perceptual motion threshold tests to determine the smallest motion they can reliably sense for yaw rotation, interaural translation and roll tilt. Each subject is tested twice, once with promethazine then once with placebo, separated by >4 days. This arm corresponds to results published in Diaz-Artiles et al 2017.
Subjects undergo perceptual motion threshold tests to determine the smallest motion they can reliably sense for yaw rotation, interaural translation and roll tilt. Each subject is tested twice, once with placebo then once with promethazine, separated by >4 days. This arm corresponds to results published in Diaz-Artiles et al 2017.