Cranberry Tablets Versus Nitrofurantoin Prophylaxis for Urinary Tract Infection Prevention After Urogynecologic Surgery
Urinary Tract Infections, Pelvic Organ Prolapse, Urinary Incontinence
About this trial
This is an interventional prevention trial for Urinary Tract Infections
Eligibility Criteria
Inclusion Criteria:
- Age ≥ 18
- English-speaking
- Plan for POP or UI surgery
Exclusion Criteria:
- Pregnancy
- Urethral diverticulectomy
- Urogenital fistula repair
- Sacral neuromodulation
- Congenital urogenital anomaly
- Allergy to cranberry products
- Allergy to nitrofurantoin
- Dependent on catheterization preoperatively
- Recurrent UTI's (3 or more culture proven UTI's over the past consecutive 12 months)
- Known creatinine clearance <60 mL/min
- Non-English, Non-Spanish speaking
Sites / Locations
- Brigham and Women's Hospital
Arms of the Study
Arm 1
Arm 2
Active Comparator
Active Comparator
Nitrofurantoin prophylaxis/Placebo
Cranberry capsules
Subjects will receive Nitrofurantoin 100mg capsules (Bottle A) once a day until they pass their voiding trial and no longer require transurethral catheterization. Subjects will be switched to Placebo capsules (Bottle B) once a day, starting the day after they pass their voiding trial until the end of the 28 day study period.
Subjects will receive TheraCran® One Cranberry 36mg capsules (Bottle A) once a day until they pass their voiding trial and no longer require transurethral catheterization. Subjects will be switched to another bottle of TheraCran® One Cranberry 36mg capsules (Bottle B) once a day, starting the day after they pass their voiding trial until the end of the 28 day study period.