Curcumin in Patients With Mild to Moderate Alzheimer's Disease

Inclusion Criteria: Male or female at least 50 years old Diagnosis of probable AD No history of significant psychiatric or non-AD neurological disease Proficient in English to be able to perform cognitive testing Caregiver available to monitor and administer medication and to accompany patient to every clinical visit On stable doses of cholinesterase inhibitors and memantine (Alzheimer's medications) for 3 months prior to enrollment On stable doses of all other allowed medications for at least one month prior to starting the study medication Exclusion Criteria: Current or recent major psychiatric illness (i.e. bipolar disorder, schizophrenia) Significant, uncontrolled systemic illness (i.e. chronic renal failure, chronic liver disease, poorly controlled diabetes, or poorly controlled congestive heart failure) Recent history of gastrointestinal bleeding or ulceration Alcoholism or substance abuse within the past year Familial, autosomal dominant Alzheimer's disease due to a mutation in a known gene (Presenilin-1, Presenilin-2, or Amyloid Precursor Protein) NSAIDs (e.g. ibuprofen, naproxen, etc.) taken on a regular basis (more than 3 times per week) Aspirin at doses more than 325 mg per day Coumadin, heparin, other anticoagulants Antioxidants or other supplements including gingko biloba, coenzyme Q10, alpha-lipoic acid Vitamin E at doses more than 2,000 IU per day Vitamin C at doses more than 500 mg per day