Cutaneous Microcirculation After Remote Ischemic Preconditioning
Burn Injury, Acute Wound, Chronic Wound
About this trial
This is an interventional basic science trial for Burn Injury
Eligibility Criteria
Inclusion Criteria:
Group A (n=20): Consent-capable male and female patients ≥18 years of age who have sustained a second-degree burn on ≥1% and ≤30% of the surface of the body.
Group B (n=20): Consent-capable male and female patients ≥18 years of age who require a skin excision for the purpose of a skin graft. The minimal size of the skin-graft donor site must not be less than 1% of TBSA.
Group C (n=20): Consent-capable male and female patients ≥18 years of age suffering from a wound that has not yet healed ≥3 weeks. The minimal size of the wound site must not be less than 1% of TBSA.
Group D (n=20): Consent-capable healthy male and female probands ≥18 years of age serving as sham group. None of the the criteria of groups A-C must be evident. No soft tissue injury must be evident.
Exclusion Criteria:
General exclusion criteria
- below 18 years of age
- wounds requiring artificial respiration, since consent for the study participation is unobtainable
Exclusion Criteria Groups A, B, D:
- peripheral arterial occlusive disease
- vasculitis
- diabetes mellitus
- chronic kidney or liver disease
- cardiac dysfunction
- arterial hypo- or hypertension
Anamnestic exclusion criteria
- ongoing immunosuppressive or chemotherapy treatment
- drug abuse
- systemic skin diseases
- systemic and local cortisone therapy
Sites / Locations
- University of Schleswig-Holstein
Arms of the Study
Arm 1
Arm 2
Arm 3
Arm 4
Experimental
Experimental
Experimental
Active Comparator
Second-Degree Burn
Skin Excision (for Skin Graft)
Chronic Wound
Intact Skin
Group A (n=20): Consent-capable male and female patients ≥18 years of age who have sustained a second-degree burn on ≥1% and ≤30% of the surface of the body. Intervention: Remote Ischemic Preconditioning (by Blood Pressure Cuff)
Group B (n=20): Consent-capable male and female patients ≥18 years of age who require a skin excision for the purpose of a skin graft. The minimal size of the skin-graft donor site must not be less than 1% of TBSA. Intervention: Remote Ischemic Preconditioning (by Blood Pressure Cuff)
Group C (n=20): Consent-capable male and female patients ≥18 years of age suffering from a wound that has not yet healed ≥3 weeks. The minimal size of the wound site must not be less than 1% of TBSA. Intervention: Remote Ischemic Preconditioning (by Blood Pressure Cuff)
Group D (n=20): Consent-capable healthy male and female probands ≥18 years of age serving as sham group. None of the the criteria of groups A-C must be evident. Intervention: Remote Ischemic Preconditioning (by Blood Pressure Cuff)