Cytisine Compared to Combination NRT in Relapsed Smokers (CYTvsNRT+)
Smoking Cessation, Coronary Artery Disease
About this trial
This is an interventional treatment trial for Smoking Cessation focused on measuring Tobacco, Relapse prevention
Eligibility Criteria
Inclusion Criteria:
- Patient is enrolled in UOHI's Quit Smoking Program;
- Patient has relapsed to daily smoking ≥10 cigarettes per day within 90 days of discharge from UOHI;
- Patient is currently smoking ≥10 cigarettes per day.
Exclusion Criteria:
- Patient has used NRT, cytisine, varenicline, bupropion or a nicotine-containing vaping device within in the past 15 days;
- Patient is unavailable to come to UOHI for assessments;
- Patient is unable to provide informed consent;
- Patient is unable to comprehend the intervention instructions (in the opinion of qualified investigators)
Sites / Locations
- University of Ottawa Heart Insitute - Prevention and Wellness CentreRecruiting
Arms of the Study
Arm 1
Arm 2
Experimental
Active Comparator
Cytisine
NRT+
Cravv™ (Zpharm, Waterloo) is a natural health product licensed by Health Canada to assist with smoking cessation; each oral capsule contains 1.5mg of cytisine. The dosing is as follows: 6 capsules daily for the first 3 days; 5 capsules daily for days 4-12; 4 capsules daily for days 13-16; 3 capsules daily for days 17-20; and 1-2 capsules daily for days 21-25.
The Nicoderm® patch plus Nicorette® Lozenge will be provided to participants in the combination NRT group. Participants smoking less than 15 cigarettes per day will be provided with 14 mg patches while those smoking 15 or more cigarettes per day will receive 21 mg patches. Participants will be told to apply a new patch each morning. Participants will be instructed to use the lozenges as needed (up to 15 per day) to overcome nicotine cravings. Lozenges are available in both 2mg and 4mg strengths. For those who are smoking less than 15 cigarettes per day, they will be given the 2mg strength. For those who are smoking 15 or more cigarettes per day, they will receive the 4mg strength.