Decoding of the Expression of Tumor Suppressor P2RX7 in Inflammatory and Malignant Colonic Mucosa (P2RX7)
Crohn Disease-Associated Colorectal Adenocarcinoma
About this trial
This is an interventional diagnostic trial for Crohn Disease-Associated Colorectal Adenocarcinoma
Eligibility Criteria
Inclusion Criteria:
· All the patients requiring an endoscopy within the framework of a colorectal cancer
- All the patients requiring a low digestive endoscopy within the framework of the diagnosis or of the follow-up of a colorectal cancer, realized in the CHU of Nice.
- Realization of a preliminary medical examination
- Obligation for all the patients to be affiliated to the Social Security
- Signature of the informed consent
Exclusion Criteria:
• Pushed acute severe of the disease defined by the score of Truelove and Witss or the score of Lichtiger > 10 (cf appendix)
- severe endoscopic Hurts returning the practice of dangerous additional biopsies
- Disorders of the coagulation or the patient under anti-vitamin K, aspirin or clopidogrel.
- Patient presenting an unchecked renal, respiratory, hepatic or cardiac insufficiency
- Patient known positive HIV
- vulnerable People: pregnant or breast-feeding women (a pregnancy test will be realized), minors, adults under guardianship or guardianships, deprived of freedom
Sites / Locations
- CHU de Nice
Arms of the Study
Arm 1
Other
biopsy
We will use colonic biopsies performed in the gastroenterology after obtaining consent from the patient and the agreement of the committee for the protection of persons. 5 biopsy will be performed for all patients except those with colon cancer for xhich we realize only 3 colonic biopsy (1 in healthy area and 2 in cancerous area ) To obtain statistically significant results we will establish the following six study groups, as far as possible matched for age and sex: healthy patients; patients with colonic Crohn disease in acute phase; patients with colonic Crohn disease in chronic phase; patients with ulcerative colitis in acute phase; patients with ulcerative colitis in chronic phase; patients with colon cancer