Dehydroepiandrosterone Effects on HIV-1 Replication

Inclusion criteria: Evidence of HIV-1 infection HIV RNA <50 copies/mL Stable antiretroviral treatment regimen for at least 8 weeks Age 18 years or older Normal pap smear and mammograph within 1 year (females) Normal prostate-specific antigen level with in one year, age adjusted (males) Exclusion criteria: Active opportunistic infections or malignancy other than localized cutaneous KS lesions Concurrent or prior use within the past 8 weeks of DHA, testosterone, other anabolic steroids, corticosteroids, megestrol acetate, growth hormone, IL-2, or thalidomide Diagnosis of AIDS Dementia Complex (stage II or higher) Active substance abuse (e.g., alcohol or injection drugs) Evidence of severe liver dysfunction or hepatic transaminases greater than 3x the upper normal limit Pregnant or breast-feeding History of endocrinologically-responsive tumors (e.g., breast, ovarian, uterine, or prostatic cancer, or malignant melanoma)