Dendritic Cell Vaccine to Prevent COVID-19
COVID-19
About this trial
This is an interventional prevention trial for COVID-19 focused on measuring covid-19, vaccine, dendritic cell
Eligibility Criteria
Inclusion Criteria:
- 18 years or older,
- in relatively good health with adequate physical and mental function
- including factors associated with in increased risk for medical complications associated with COVID-19 infection or increased risk for exposure to SARS-CoV-2
Exclusion Criteria:
- Active COVID-19 infection by PCR testing
- Pre-existing IgG or IgM SARS-CoV-2 antibodies
- Pregnant, Known hypersensitivity to GM-CSF
- Known active immune deficiency disease or active HIV
- HBV, HCV, On active treatment with corticosteroids or other immunosuppressive agent
- Participated in previous COVID-19 vaccine study
Sites / Locations
- Rumah Sakit Umum Pusat Dr. KariadiRecruiting
Arms of the Study
Arm 1
Arm 2
Arm 3
Arm 4
Arm 5
Arm 6
Arm 7
Arm 8
Arm 9
Experimental
Experimental
Experimental
Experimental
Experimental
Experimental
Experimental
Experimental
Experimental
AV-COVID-19 (0.1 mg antigen, 0 mcg GMCSF)
AV-COVID-19 (0.33 mg antigen, 0 mcg GM-CSF)
AV-COVID-19 (1.0 mg antigen, 0 mcg GMCSF)
Experimental: AV-COVID-19 (0.1 mg antigen, 250 mcg GM-CSF)
AV-COVID-19 (0.33 mg antigen, 250 mcg GM-CSF)
AV-COVID-19 (1.0 mg antigen, 250 mcg GM-CSF)
AV-COVID-19 (0.1 mg antigen, 500 mcg GM-CSF)
AV-COVID-19 (0.33 mg antigen, 500 mcg GM-CSF)
AV-COVID-19 (1.0 mg antigen, 500 mcg GM-CSF)
Autologous dendritic cells previously loaded with 0.1 mg SARS-CoV-2 spike protein, admixed with 0 mcg GM-CSF
Autologous dendritic cells previously loaded with 0.33 mg SARS-CoV-2 spike protein, admixed with 0 mcg GM-CSF
Autologous dendritic cells previously loaded with 1.0 mg SARS-CoV-2 spike protein, admixed with 0 mcg GM-CSF
Autologous dendritic cells previously loaded with 0.1 mg SARS-CoV-2 spike protein, admixed with 250 mcg GM-CSF
Autologous dendritic cells previously loaded with 0.33 mg SARS-CoV-2 spike protein, admixed with 250 mcg GM-CSF
Autologous dendritic cells previously loaded with 1.0 mg SARS-CoV-2 spike protein, admixed with 250 mcg GM-CSF
Autologous dendritic cells previously loaded with 0.1 mg SARS-CoV-2 spike protein, admixed with 500 mcg GM-CSF
Autologous dendritic cells previously loaded with 0.33 mg SARS-CoV-2 spike protein, admixed with 500 mcg GM-CSF
Autologous dendritic cells previously loaded with 1.0 mg SARS-CoV-2 spike protein, admixed with 500 mcg GM-CSF