Detection of Coronary Stenosis With Intravenous Microbubbles
Coronary Stenosis, Carotid Stenosis, Myocardial Reperfusion
About this trial
This is an interventional diagnostic trial for Coronary Stenosis
Eligibility Criteria
Inclusion Criteria:
- subjects scheduled for routine echocardiogram to look for evidence of Coronary artery disease or a stress echocardiogram
- women of child-bearing potential must be taking a medically approved form of birth control with a negative urine pregnancy test
- be conscious and coherent, and be able to communicate effectively with study personnel
- last eight patients will be diabetics who smoke
- provide informed consent after receiving a verbal and written explanation of the purpose and nature of the study
Exclusion Criteria:
- severe valvular heart disease by Doppler Echocardiography
- females of child-bearing potential who are not taking a medically approved method of birth control will be excluded. If the patient is pregnant she will be excluded.
- patients who are allergic to blood or blood products will be excluded
- have contraindication to Optison, Definity, or PESDA (pulmonary HTN, cardiac shunt)
- non diabetics, non smokers
Sites / Locations
- University of Nebraska Medical Center
Arms of the Study
Arm 1
Arm 2
Arm 3
Active Comparator
Active Comparator
Active Comparator
1 Intravenous Optison Followed by Contrast Pulse Sequencing
2 Intravenous Definity followed by Contrast Pulse Sequencing
3 Intravenous PESDA followed by Contrast Pulse Sequencing
Administration of Optison (0.1-0.4 mL) intravenously followed by Contrast Pulse Sequencing to image both the coronary and carotid arteries. Use will depend on availability of the contrast for the given study Optison will not be used on patients with blood allergies or Jehovah Witnesses
Intravenous injection of Definity (0.05-0.20 mL) followed by Contrast Pulse Sequencing to image both coronary and carotid arteries
Intravenous injection of PESDA at a rate of 0.05-0.20 mL followed by Contrast Pulse Sequencing image of coronary and carotid arteries PESDA will be used exclusively in patients who are eligible for other IRB studies