Determinants of Muscle Strength in Chronic Kidney Disease

Aim of this study is to determine in chronic kidney disease patients: the involvement of malnutrition inflammation and atherogenesis syndrome (increase in C reactive protein and decrease in serum albumin) on voluntary muscle strength impairment the relationship between voluntary muscle strength and muscle mass the relationship between voluntary muscle strength and lean body mass the correlation between voluntary muscle strength and physical activity

Aim of this study is to determine in chronic kidney disease patients: the involvement of malnutrition inflammation and atherogenesis syndrome (increase in C reactive protein and decrease in serum albumin) on voluntary muscle strength impairment (estimated by handheld dynamometer) the relationship between voluntary muscle strength and muscle mass (estimated by creatinine index) the relationship between voluntary muscle strength and lean body mass (estimated by bioelectrical impedance analysis) the correlation between voluntary muscle strength and physical activity (the physical activity being estimated by the "Voorrips" score questionnaire)

chronic kidney disease, malnutrition inflammation atherogenesis syndrome, muscle strength, muscle mass, lean body mass, physical activity

single evaluation (the day of inclusion) of muscle strength (by handheld dynamometer), muscle mass (by creatinine index estimation), lean body mass (by electrical bioimpedance analysis), physical activity (by "Voorrips" score questionnaire), inflammatory and nutritional status.

Inclusion Criteria: chronic kidney disease patient with extrarenal replacement therapy by hemodialysis for at least 3 months stable clinical condition (absence of infection, stroke or acute decompensation) Exclusion Criteria: chronic kidney disease without extrarenal replacement therapy history of renal transplantation

Souweine JS, Kuster N, Chenine L, Rodriguez A, Patrier L, Morena M, Badia E, Chalabi L, Raynal N, Ohresser I, Leray-Moragues H, Mercier J, Hayot M, Le Quintrec M, Gouzi F, Cristol JP. Physical inactivity and protein energy wasting play independent roles in muscle weakness in maintenance haemodialysis patients. PLoS One. 2018 Aug 1;13(8):e0200061. doi: 10.1371/journal.pone.0200061. eCollection 2018.