Dexamethasone Treatment for OSA in Children
Obstructive Sleep Apnea
About this trial
This is an interventional treatment trial for Obstructive Sleep Apnea focused on measuring Dexamethasone, Corticosteroid
Eligibility Criteria
Inclusion Criteria: Polysomnogram diagnosed with moderate to severe Obstructive sleep apnea (OAHI >5 events/hour) Aged 2-10 years Presence of adenotonsillar hypertrophy Ability to take oral medication and be willing to adhere to the dosing regimen Informed consent provided in accordance with institutional policies Exclusion Criteria: Previous adenotonsillectomy Presence of symptoms of an upper respiratory tract infection Co-existing central sleep apnea Hypertension Prior or current evidence for abnormal glucose tolerance Contraindication for dexamethasone or components of dexamethasone oral suspension, Treatment with nasal or systemic corticosteroids within 4 weeks prior to the intervention OSA with associated oxygen desaturations <90% for 2 continuous minutes Need for non-invasive ventilation long-term due to underlying disease Current systemic fungal infections Patients with clinically relevant varicella exposure
Sites / Locations
- The Hospital for Sick ChildrenRecruiting
Arms of the Study
Arm 1
Arm 2
Experimental
Placebo Comparator
Dexamethasone Treatment
Placebo Treatment
Oral Dexamethasone treatment
Placebo control