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Diabetes Control and Complications Trial (DCCT)

Primary Purpose

Type 1 Diabetes Mellitus

Status
Completed
Phase
Not Applicable
Locations
International
Study Type
Interventional
Intervention
Insulin
Sponsored by
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
About
Eligibility
Locations
Outcomes
Full info

About this trial

This is an interventional treatment trial for Type 1 Diabetes Mellitus

Eligibility Criteria

13 Years - 39 Years (Child, Adult)All Sexes

Eligibility Criteria: The major criteria for eligibility included insulin dependence, as evidenced by deficient C-peptide secretion; an age of 13 to 39 years; and the absence of hypertension, hypercholesterolemia, and severe diabetic complications or medical conditions. To be eligible for the primary-prevention cohort, patients were required to have had insulin dependent diabetes mellitus (IDDM) for one to five years, to have no retinopathy as detected by seven-field stereoscopic fundus photography, and to have urinary albumin excretion of less than 40 mg per 24 hours. To be eligible for the secondary-intervention cohort, the patients were required to have IDDM for 1 to 15 years, to have very-mild to moderate nonproliferative retinopathy, and to have urinary albumin excretion of less than 200 mg per 24 hours.

Sites / Locations

  • University of California
  • Yale University School of Medicine
  • University of South Florida College of Medicine
  • Northwestern University
  • DCCT Central Autonomic Coding Unit
  • University of Iowa
  • University of Maryland
  • George Washington University, Biostatistics Center
  • Massachusetts General Hospital
  • Joslin Diabetes Center, Inc.
  • University of Michigan, Sattelite-Henry Ford Hospital
  • Henry Ford Hospital
  • International Diabetes Center
  • DCCT Central Nutrition Coding Unit
  • DCCT Central ECG Reading Unit
  • DCCT Central Biochemistry Laboratory
  • University of Minnesota
  • Mayo Foundation
  • Backup DCCT Central HbA1c Lab
  • University of Missouri
  • Washington University at St. Louis
  • University of New Mexico School of Medicine
  • Albert Einstein College of Medicine
  • Cornell University Medical College, The New York Hospital
  • Case Western Reserve University, Lakeside Hospital
  • University of Pennsylvania, The Children's Hospital of Philadelphia
  • University of Pittsburgh, Children's Hospital
  • DCCT Central Neurobehavioral Coding Unit
  • Medical University of South Carolina
  • University of Tennessee
  • Vanderbilt University, Diabetes Research and Training Center
  • Vanderbilt University
  • University of Texas
  • University of Washington
  • DCCT Central Ophthalmologic Reading Unit, Fundus Photo Reading Center
  • University of Washington (British Columbia Satellite)
  • University of Western Ontario
  • University of Toronto, Mount Sinai Hospital

Outcomes

Primary Outcome Measures

Secondary Outcome Measures

Full Information

First Posted
August 2, 2006
Last Updated
March 1, 2010
Sponsor
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
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1. Study Identification

Unique Protocol Identification Number
NCT00360815
Brief Title
Diabetes Control and Complications Trial (DCCT)
Official Title
Diabetes Control and Complications Trial (DCCT)
Study Type
Interventional

2. Study Status

Record Verification Date
March 2010
Overall Recruitment Status
Completed
Study Start Date
August 1983 (undefined)
Primary Completion Date
undefined (undefined)
Study Completion Date
April 1993 (undefined)

3. Sponsor/Collaborators

Name of the Sponsor
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)

4. Oversight

5. Study Description

Brief Summary
Background. Long-term microvascular and neurologic complications cause major morbidity and mortality in patients with insulin-dependent diabetes mellitus (IDDM). We examined whether intensive treatment with the goal of maintaining blood glucose concentrations close to the normal range could decrease the frequency and severity of these complications. Methods. A total of 1441 patients with IDDM -- 726 with no retinopathy at base line (the primary-prevention cohort) and 715 with mild retinopathy (the secondary-intervention cohort) were randomly assigned to intensive therapy administered either with an external insulin pump or by three or more daily insulin injections and guided by frequent blood glucose monitoring or to conventional therapy with one or two daily insulin injections. The patients were followed for a mean of 6.5 years, and the appearance and progression of retinopathy and other complications were assessed regularly.

6. Conditions and Keywords

Primary Disease or Condition Being Studied in the Trial, or the Focus of the Study
Type 1 Diabetes Mellitus

7. Study Design

Primary Purpose
Treatment
Study Phase
Not Applicable
Interventional Study Model
Parallel Assignment
Masking
None (Open Label)
Allocation
Randomized
Enrollment
1441 (false)

8. Arms, Groups, and Interventions

Intervention Type
Behavioral
Intervention Name(s)
Insulin

10. Eligibility

Sex
All
Minimum Age & Unit of Time
13 Years
Maximum Age & Unit of Time
39 Years
Eligibility Criteria
Eligibility Criteria: The major criteria for eligibility included insulin dependence, as evidenced by deficient C-peptide secretion; an age of 13 to 39 years; and the absence of hypertension, hypercholesterolemia, and severe diabetic complications or medical conditions. To be eligible for the primary-prevention cohort, patients were required to have had insulin dependent diabetes mellitus (IDDM) for one to five years, to have no retinopathy as detected by seven-field stereoscopic fundus photography, and to have urinary albumin excretion of less than 40 mg per 24 hours. To be eligible for the secondary-intervention cohort, the patients were required to have IDDM for 1 to 15 years, to have very-mild to moderate nonproliferative retinopathy, and to have urinary albumin excretion of less than 200 mg per 24 hours.
Overall Study Officials:
First Name & Middle Initial & Last Name & Degree
Oscar B. Crofford, M.D.
Organizational Affiliation
Vanderbilt University
Official's Role
Study Chair
First Name & Middle Initial & Last Name & Degree
Carolyn Siebert, M.P.H.
Organizational Affiliation
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Official's Role
Study Director
First Name & Middle Initial & Last Name & Degree
Patricia A. Cleary, M.S.
Organizational Affiliation
George Washington University
Official's Role
Principal Investigator
Facility Information:
Facility Name
University of California
City
La Jolla
State/Province
California
ZIP/Postal Code
92093-0620
Country
United States
Facility Name
Yale University School of Medicine
City
New Haven
State/Province
Connecticut
ZIP/Postal Code
06510
Country
United States
Facility Name
University of South Florida College of Medicine
City
Tampa
State/Province
Florida
ZIP/Postal Code
33612
Country
United States
Facility Name
Northwestern University
City
Chicago
State/Province
Illinois
ZIP/Postal Code
60611
Country
United States
Facility Name
DCCT Central Autonomic Coding Unit
City
Springfield
State/Province
Illinois
ZIP/Postal Code
62702
Country
United States
Facility Name
University of Iowa
City
Iowa City
State/Province
Iowa
ZIP/Postal Code
52242
Country
United States
Facility Name
University of Maryland
City
Baltimore
State/Province
Maryland
ZIP/Postal Code
21201
Country
United States
Facility Name
George Washington University, Biostatistics Center
City
Rockville
State/Province
Maryland
ZIP/Postal Code
20852
Country
United States
Facility Name
Massachusetts General Hospital
City
Boston
State/Province
Massachusetts
ZIP/Postal Code
02114
Country
United States
Facility Name
Joslin Diabetes Center, Inc.
City
Boston
State/Province
Massachusetts
ZIP/Postal Code
02215
Country
United States
Facility Name
University of Michigan, Sattelite-Henry Ford Hospital
City
Ann Arbor
State/Province
Michigan
ZIP/Postal Code
48109-0832
Country
United States
Facility Name
Henry Ford Hospital
City
Detroit
State/Province
Michigan
ZIP/Postal Code
48202
Country
United States
Facility Name
International Diabetes Center
City
Minneapolis
State/Province
Minnesota
ZIP/Postal Code
55416
Country
United States
Facility Name
DCCT Central Nutrition Coding Unit
City
Minneapolis
State/Province
Minnesota
ZIP/Postal Code
55454-1015
Country
United States
Facility Name
DCCT Central ECG Reading Unit
City
Minneapolis
State/Province
Minnesota
ZIP/Postal Code
55455-1015
Country
United States
Facility Name
DCCT Central Biochemistry Laboratory
City
Minneapolis
State/Province
Minnesota
ZIP/Postal Code
55455-9980
Country
United States
Facility Name
University of Minnesota
City
Minneapolis
State/Province
Minnesota
ZIP/Postal Code
55455
Country
United States
Facility Name
Mayo Foundation
City
Rochester
State/Province
Minnesota
ZIP/Postal Code
55905
Country
United States
Facility Name
Backup DCCT Central HbA1c Lab
City
Columbia
State/Province
Missouri
ZIP/Postal Code
65201
Country
United States
Facility Name
University of Missouri
City
Columbia
State/Province
Missouri
ZIP/Postal Code
65212
Country
United States
Facility Name
Washington University at St. Louis
City
St. Louis
State/Province
Missouri
ZIP/Postal Code
63110
Country
United States
Facility Name
University of New Mexico School of Medicine
City
Albuquerque
State/Province
New Mexico
ZIP/Postal Code
87131
Country
United States
Facility Name
Albert Einstein College of Medicine
City
Bronx
State/Province
New York
ZIP/Postal Code
10461
Country
United States
Facility Name
Cornell University Medical College, The New York Hospital
City
New York
State/Province
New York
ZIP/Postal Code
10021
Country
United States
Facility Name
Case Western Reserve University, Lakeside Hospital
City
Cleveland
State/Province
Ohio
ZIP/Postal Code
44106
Country
United States
Facility Name
University of Pennsylvania, The Children's Hospital of Philadelphia
City
Philadelphia
State/Province
Pennsylvania
ZIP/Postal Code
19104
Country
United States
Facility Name
University of Pittsburgh, Children's Hospital
City
Pittsburgh
State/Province
Pennsylvania
ZIP/Postal Code
15213-3417
Country
United States
Facility Name
DCCT Central Neurobehavioral Coding Unit
City
Pittsburgh
State/Province
Pennsylvania
ZIP/Postal Code
15213
Country
United States
Facility Name
Medical University of South Carolina
City
Charleston
State/Province
South Carolina
ZIP/Postal Code
29403-5851
Country
United States
Facility Name
University of Tennessee
City
Memphis
State/Province
Tennessee
ZIP/Postal Code
38163
Country
United States
Facility Name
Vanderbilt University, Diabetes Research and Training Center
City
Nashville
State/Province
Tennessee
ZIP/Postal Code
37212
Country
United States
Facility Name
Vanderbilt University
City
Nashville
State/Province
Tennessee
ZIP/Postal Code
37232-2230
Country
United States
Facility Name
University of Texas
City
Dallas
State/Province
Texas
ZIP/Postal Code
75235
Country
United States
Facility Name
University of Washington
City
Seattle
State/Province
Washington
ZIP/Postal Code
98195
Country
United States
Facility Name
DCCT Central Ophthalmologic Reading Unit, Fundus Photo Reading Center
City
Madison
State/Province
Wisconsin
ZIP/Postal Code
53705-0240
Country
United States
Facility Name
University of Washington (British Columbia Satellite)
City
Vancouver
State/Province
British Columbia
ZIP/Postal Code
V5Z 3N9
Country
Canada
Facility Name
University of Western Ontario
City
London
State/Province
Ontario
ZIP/Postal Code
N6A 5A5
Country
Canada
Facility Name
University of Toronto, Mount Sinai Hospital
City
Toronto
State/Province
Ontario
ZIP/Postal Code
M5G 1X5
Country
Canada

12. IPD Sharing Statement

Citations:
PubMed Identifier
35972222
Citation
Lachin JM, Bebu I, Gao X, Nathan DM, Zinman B; Diabetes Control and Complications Trial/Epidemiology of Diabetes Interventions and Complications (DCCT/EDIC) Research Group. Association of Estimated Time-in-Range Capillary Glucose Levels Versus HbA1c With Progression of Microvascular Complications in the Diabetes Control and Complications Trial. Diabetes Care. 2022 Oct 1;45(10):2445-2448. doi: 10.2337/dc21-2298.
Results Reference
derived
PubMed Identifier
35880807
Citation
Martin CL, Trapani VR, Backlund JC, Lee P, Braffett BH, Bebu I, Lachin JM, Jacobson AM, Gubitosi-Klug R, Herman WH; DCCT/EDIC Research Group. Physical Function in Middle-aged and Older Adults With Type 1 Diabetes: Long-term Follow-up of the Diabetes Control and Complications Trial/Epidemiology of Diabetes Interventions and Complications Study. Diabetes Care. 2022 Sep 1;45(9):2037-2045. doi: 10.2337/dc21-2119.
Results Reference
derived
PubMed Identifier
35699949
Citation
Jacobson AM, Braffett BH, Erus G, Ryan CM, Biessels GJ, Luchsinger JA, Bebu I, Gubitosi-Klug RA, Desiderio L, Lorenzi GM, Trapani VR, Lachin JM, Bryan RN, Habes M, Nasrallah IM; DCCT/EDIC Research Group. Brain Structure Among Middle-aged and Older Adults With Long-standing Type 1 Diabetes in the DCCT/EDIC Study. Diabetes Care. 2022 Aug 1;45(8):1779-1787. doi: 10.2337/dc21-2438.
Results Reference
derived
PubMed Identifier
35076697
Citation
Gubitosi-Klug RA, Braffett BH, Bebu I, Johnson ML, Farrell K, Kenny D, Trapani VR, Meadema-Mayer L, Soliman EZ, Pop-Busui R, Lachin JM, Bergenstal RM, Tamborlane WV. Continuous Glucose Monitoring in Adults With Type 1 Diabetes With 35 Years Duration From the DCCT/EDIC Study. Diabetes Care. 2022 Mar 1;45(3):659-665. doi: 10.2337/dc21-0629.
Results Reference
derived
PubMed Identifier
35040196
Citation
Carlson NE, Horton KW, Hokanson JE, Cleary PA, Jacobs DR Jr, Brunzell JD, Purnell JQ; DCCT/EDIC research group. Weight gain trajectories and obesity rates in intensive and conventional treatments of type 1 diabetes from the DCCT compared with a control population without diabetes. Diabet Med. 2022 May;39(5):e14794. doi: 10.1111/dme.14794. Epub 2022 Jan 26.
Results Reference
derived
PubMed Identifier
35015817
Citation
Perkins BA, Bebu I, Gao X, Karger AB, Hirsch IB, Karanchi H, Molitch ME, Zinman B, Lachin JM, de Boer IH. Early Trajectory of Estimated Glomerular Filtration Rate and Long-term Advanced Kidney and Cardiovascular Complications in Type 1 Diabetes. Diabetes Care. 2022 Mar 1;45(3):585-593. doi: 10.2337/dc21-1883.
Results Reference
derived
PubMed Identifier
35007329
Citation
Boyko EJ, Zelnick LR, Braffett BH, Pop-Busui R, Cowie CC, Lorenzi GM, Gubitosi-Klug R, Zinman B, de Boer IH. Risk of Foot Ulcer and Lower-Extremity Amputation Among Participants in the Diabetes Control and Complications Trial/Epidemiology of Diabetes Interventions and Complications Study. Diabetes Care. 2022 Feb 1;45(2):357-364. doi: 10.2337/dc21-1816.
Results Reference
derived
PubMed Identifier
35000860
Citation
Steigmann L, Miller R, Trapani VR, Giannobile WV, Braffett BH, Pop-Busui R, Lorenzi G, Herman WH, Sarma AV; Diabetes Control and Complications Trial/Epidemiology of Diabetes Interventions and Complications Research Group. Type 1 diabetes and oral health: Findings from the Epidemiology of Diabetes Interventions and Complications (EDIC) study. J Diabetes Complications. 2022 Apr;36(4):108120. doi: 10.1016/j.jdiacomp.2021.108120. Epub 2022 Jan 3.
Results Reference
derived
PubMed Identifier
34873921
Citation
Polak JF, Backlund JC, Budoff M, Raskin P, Bebu I, Lachin JM; DCCT/EDIC Research Group. Coronary Artery Disease Events and Carotid Intima-Media Thickness in Type 1 Diabetes in the DCCT/EDIC Cohort. J Am Heart Assoc. 2021 Dec 21;10(24):e022922. doi: 10.1161/JAHA.121.022922. Epub 2021 Dec 7.
Results Reference
derived
PubMed Identifier
34728530
Citation
Pop-Busui R, Braffett BH, Wessells H, Herman WH, Martin CL, Jacobson AM, Sarma AV. Diabetic Peripheral Neuropathy and Urological Complications in Type 1 Diabetes: Findings From the Epidemiology of Diabetes Interventions and Complications Study. Diabetes Care. 2022 Jan 1;45(1):119-126. doi: 10.2337/dc21-1276.
Results Reference
derived
PubMed Identifier
34244538
Citation
Jenkins AJ, Braffett BH, Basu A, Bebu I, Dagogo-Jack S, Orchard TJ, Wallia A, Lopes-Virella MF, Garvey WT, Lachin JM, Lyons TJ; DCCT/EDIC Research Group. Serum urate and cardiovascular events in the DCCT/EDIC study. Sci Rep. 2021 Jul 9;11(1):14182. doi: 10.1038/s41598-021-90785-4.
Results Reference
derived
PubMed Identifier
34051936
Citation
Jacobson AM, Ryan CM, Braffett BH, Gubitosi-Klug RA, Lorenzi GM, Luchsinger JA, Trapani VR, Bebu I, Chaytor N, Hitt SM, Farrell K, Lachin JM; DCCT/EDIC Research Group. Cognitive performance declines in older adults with type 1 diabetes: results from 32 years of follow-up in the DCCT and EDIC Study. Lancet Diabetes Endocrinol. 2021 Jul;9(7):436-445. doi: 10.1016/S2213-8587(21)00086-3. Epub 2021 May 27.
Results Reference
derived
PubMed Identifier
33980605
Citation
Gubitosi-Klug R, Gao X, Pop-Busui R, de Boer IH, White N, Aiello LP, Miller R, Palmer J, Tamborlane W, Wallia A, Kosiborod M, Lachin JM, Bebu I; DCCT/EDIC Research Group. Associations of Microvascular Complications With the Risk of Cardiovascular Disease in Type 1 Diabetes. Diabetes Care. 2021 Jul;44(7):1499-1505. doi: 10.2337/dc20-3104. Epub 2021 May 12.
Results Reference
derived
PubMed Identifier
33883194
Citation
Bebu I, Keshavarzi S, Gao X, Braffett BH, Canty AJ, Herman WH, Orchard TJ, Dagogo-Jack S, Nathan DM, Lachin JM, Paterson AD; DCCT/EDIC Research Group. Genetic Risk Factors for CVD in Type 1 Diabetes: The DCCT/EDIC Study. Diabetes Care. 2021 Jun;44(6):1309-1316. doi: 10.2337/dc20-2388. Epub 2021 Apr 21.
Results Reference
derived
PubMed Identifier
33529168
Citation
Gubitosi-Klug RA, Braffett BH, Hitt S, Arends V, Uschner D, Jones K, Diminick L, Karger AB, Paterson AD, Roshandel D, Marcovina S, Lachin JM, Steffes M, Palmer JP; DCCT/EDIC Research Group. Residual beta cell function in long-term type 1 diabetes associates with reduced incidence of hypoglycemia. J Clin Invest. 2021 Feb 1;131(3):e143011. doi: 10.1172/JCI143011.
Results Reference
derived
PubMed Identifier
32941962
Citation
Hainsworth DP, Gao X, Bebu I, Das A, Olmos de Koo L, Barkmeier AJ, Tamborlane W, Lachin JM, Aiello LP; Diabetes Control and Complications Trial and Follow-up Epidemiology of Diabetes Interventions and Complications Research Group. Refractive Error and Retinopathy Outcomes in Type 1 Diabetes: The Diabetes Control and Complications Trial/Epidemiology of Diabetes Interventions and Complications Study. Ophthalmology. 2021 Apr;128(4):554-560. doi: 10.1016/j.ophtha.2020.09.014. Epub 2020 Sep 14.
Results Reference
derived
PubMed Identifier
32788280
Citation
Bebu I, Braffett BH, Schade D, Sivitz W, Malone JI, Pop-Busui R, Lorenzi GM, Lee P, Trapani VR, Wallia A, Herman WH, Lachin JM; DCCT/EDIC Research Group. An Observational Study of the Equivalence of Age and Duration of Diabetes to Glycemic Control Relative to the Risk of Complications in the Combined Cohorts of the DCCT/EDIC Study. Diabetes Care. 2020 Oct;43(10):2478-2484. doi: 10.2337/dc20-0226. Epub 2020 Aug 11.
Results Reference
derived
PubMed Identifier
32694834
Citation
Chen Z, Miao F, Braffett BH, Lachin JM, Zhang L, Wu X, Roshandel D, Carless M, Li XA, Tompkins JD, Kaddis JS, Riggs AD, Paterson AD; DCCT/EDIC Study Group; Natarajan R. DNA methylation mediates development of HbA1c-associated complications in type 1 diabetes. Nat Metab. 2020 Aug;2(8):744-762. doi: 10.1038/s42255-020-0231-8. Epub 2020 Jul 20.
Results Reference
derived
PubMed Identifier
32051148
Citation
Braffett BH, Gubitosi-Klug RA, Albers JW, Feldman EL, Martin CL, White NH, Orchard TJ, Lopes-Virella M, Lachin JM, Pop-Busui R; DCCT/EDIC Research Group. Risk Factors for Diabetic Peripheral Neuropathy and Cardiovascular Autonomic Neuropathy in the Diabetes Control and Complications Trial/Epidemiology of Diabetes Interventions and Complications (DCCT/EDIC) Study. Diabetes. 2020 May;69(5):1000-1010. doi: 10.2337/db19-1046. Epub 2020 Feb 12.
Results Reference
derived
PubMed Identifier
32001614
Citation
Bebu I, Schade D, Braffett B, Kosiborod M, Lopes-Virella M, Soliman EZ, Herman WH, Bluemke DA, Wallia A, Orchard T, Lachin JM; DCCT/EDIC Research Group. Risk Factors for First and Subsequent CVD Events in Type 1 Diabetes: The DCCT/EDIC Study. Diabetes Care. 2020 Apr;43(4):867-874. doi: 10.2337/dc19-2292. Epub 2020 Jan 30.
Results Reference
derived
PubMed Identifier
31332032
Citation
Braffett BH, Dagogo-Jack S, Bebu I, Sivitz WI, Larkin M, Kolterman O, Lachin JM; DCCT/EDIC Research Group. Response to Comment on Braffett et al. Association of Insulin Dose, Cardiometabolic Risk Factors, and Cardiovascular Disease in Type 1 Diabetes During 30 Years of Follow-up in the DCCT/EDIC Study. Diabetes Care 2019;42:657-664. Diabetes Care. 2019 Aug;42(8):e137. doi: 10.2337/dci19-0026. No abstract available.
Results Reference
derived
PubMed Identifier
30882596
Citation
Sarma AV, Hotaling JM, de Boer IH, Dunn RL, Oerline MK, Singh K, Goldberg J, Jacobson A, Braffett B, Herman WH, Pop-Busui R, Wessells H; DCCT/EDIC Research Group. Blood pressure, antihypertensive medication use, and risk of erectile dysfunction in men with type I diabetes. J Hypertens. 2019 May;37(5):1070-1076. doi: 10.1097/HJH.0000000000001988.
Results Reference
derived
PubMed Identifier
30833370
Citation
Perkins BA, Bebu I, de Boer IH, Molitch M, Tamborlane W, Lorenzi G, Herman W, White NH, Pop-Busui R, Paterson AD, Orchard T, Cowie C, Lachin JM; Diabetes Control and Complications Trial (DCCT)/Epidemiology of Diabetes Interventions and Complications (EDIC) Research Group. Risk Factors for Kidney Disease in Type 1 Diabetes. Diabetes Care. 2019 May;42(5):883-890. doi: 10.2337/dc18-2062. Epub 2019 Mar 4.
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PubMed Identifier
30833368
Citation
Hainsworth DP, Bebu I, Aiello LP, Sivitz W, Gubitosi-Klug R, Malone J, White NH, Danis R, Wallia A, Gao X, Barkmeier AJ, Das A, Patel S, Gardner TW, Lachin JM; Diabetes Control and Complications Trial (DCCT)/Epidemiology of Diabetes Interventions and Complications (EDIC) Research Group. Risk Factors for Retinopathy in Type 1 Diabetes: The DCCT/EDIC Study. Diabetes Care. 2019 May;42(5):875-882. doi: 10.2337/dc18-2308. Epub 2019 Mar 4.
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PubMed Identifier
30728218
Citation
Braffett BH, Dagogo-Jack S, Bebu I, Sivitz WI, Larkin M, Kolterman O, Lachin JM; DCCT/EDIC Research Group. Association of Insulin Dose, Cardiometabolic Risk Factors, and Cardiovascular Disease in Type 1 Diabetes During 30 Years of Follow-up in the DCCT/EDIC Study. Diabetes Care. 2019 Apr;42(4):657-664. doi: 10.2337/dc18-1574. Epub 2019 Feb 6.
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PubMed Identifier
30104298
Citation
Wessells H, Braffett BH, Holt SK, Jacobson AM, Kusek JW, Cowie C, Dunn RL, Sarma AV; DCCT/EDIC Study Group. Burden of Urological Complications in Men and Women With Long-standing Type 1 Diabetes in the Diabetes Control and Complications Trial/Epidemiology of Diabetes Interventions and Complications Cohort. Diabetes Care. 2018 Oct;41(10):2170-2177. doi: 10.2337/dc18-0255. Epub 2018 Aug 13.
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PubMed Identifier
30082172
Citation
Herman WH, Braffett BH, Kuo S, Lee JM, Brandle M, Jacobson AM, Prosser LA, Lachin JM. What are the clinical, quality-of-life, and cost consequences of 30 years of excellent vs. poor glycemic control in type 1 diabetes? J Diabetes Complications. 2018 Oct;32(10):911-915. doi: 10.1016/j.jdiacomp.2018.05.007. Epub 2018 Jun 12.
Results Reference
derived
PubMed Identifier
30064713
Citation
Herman WH, Braffett BH, Kuo S, Lee JM, Brandle M, Jacobson AM, Prosser LA, Lachin JM. The 30-year cost-effectiveness of alternative strategies to achieve excellent glycemic control in type 1 diabetes: An economic simulation informed by the results of the diabetes control and complications trial/epidemiology of diabetes interventions and complications (DCCT/EDIC). J Diabetes Complications. 2018 Oct;32(10):934-939. doi: 10.1016/j.jdiacomp.2018.06.005. Epub 2018 Jun 12.
Results Reference
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PubMed Identifier
29576550
Citation
Basu A, Jenkins AJ, Stoner JA, Zhang Y, Klein RL, Lopes-Virella MF, Garvey WT, Schade DS, Wood J, Alaupovic P, Lyons TJ; Diabetes Control and Complications Trial/Epidemiology of Diabetes Interventions and Complications Research Group. Apolipoprotein-defined lipoprotein subclasses, serum apolipoproteins, and carotid intima-media thickness in T1D. J Lipid Res. 2018 May;59(5):872-883. doi: 10.1194/jlr.P080143. Epub 2018 Mar 25.
Results Reference
derived
PubMed Identifier
29177052
Citation
de Boer IH, Gao X, Bebu I, Hoofnagle AN, Lachin JM, Paterson A, Perkins BA, Saenger AK, Steffes MW, Zinman B, Molitch ME. Biomarkers of tubulointerstitial damage and function in type 1 diabetes. BMJ Open Diabetes Res Care. 2017 Nov 14;5(1):e000461. doi: 10.1136/bmjdrc-2017-000461. eCollection 2017.
Results Reference
derived
PubMed Identifier
29138273
Citation
Purnell JQ, Braffett BH, Zinman B, Gubitosi-Klug RA, Sivitz W, Bantle JP, Ziegler G, Cleary PA, Brunzell JD; DCCT/EDIC Research Group. Impact of Excessive Weight Gain on Cardiovascular Outcomes in Type 1 Diabetes: Results From the Diabetes Control and Complications Trial/Epidemiology of Diabetes Interventions and Complications (DCCT/EDIC) Study. Diabetes Care. 2017 Dec;40(12):1756-1762. doi: 10.2337/dc16-2523.
Results Reference
derived
PubMed Identifier
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Purnell JQ, Zinman B, Brunzell JD; DCCT/EDIC Research Group. The effect of excess weight gain with intensive diabetes mellitus treatment on cardiovascular disease risk factors and atherosclerosis in type 1 diabetes mellitus: results from the Diabetes Control and Complications Trial/Epidemiology of Diabetes Interventions and Complications Study (DCCT/EDIC) study. Circulation. 2013 Jan 15;127(2):180-7. doi: 10.1161/CIRCULATIONAHA.111.077487. Epub 2012 Dec 4.
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Turkbey EB, Backlund JY, Genuth S, Jain A, Miao C, Cleary PA, Lachin JM, Nathan DM, van der Geest RJ, Soliman EZ, Liu CY, Lima JA, Bluemke DA; DCCT/EDIC Research Group. Myocardial structure, function, and scar in patients with type 1 diabetes mellitus. Circulation. 2011 Oct 18;124(16):1737-46. doi: 10.1161/CIRCULATIONAHA.111.022327. Epub 2011 Sep 26.
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Polak JF, Backlund JY, Cleary PA, Harrington AP, O'Leary DH, Lachin JM, Nathan DM; DCCT/EDIC Research Group. Progression of carotid artery intima-media thickness during 12 years in the Diabetes Control and Complications Trial/Epidemiology of Diabetes Interventions and Complications (DCCT/EDIC) study. Diabetes. 2011 Feb;60(2):607-13. doi: 10.2337/db10-0296.
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