Diagnosis of Pheochromocytoma

INCLUSION CRITERIA: Patients are eligible for inclusioni this study if they are adults or children of age 3 years old and up with known, sporadic or familial PHEO/PGL, on the basis of one or more of the following: High levels of blood or urinary catecholamines, metanephrines, methoxytyramine or chromogranin A. Highly suspected presence of PHEO/PGL based on imaging studies, even with normal biochemistry. Personal or family history of PHEO/PGL or genetic mutations known to predispose individuals to develop PHEO/PGL. Patients can be studied to provide blood/urine samples for biochemical, proteomic, and/or genetic and epigenetic analysis. Signed informed consent is required. Patients must be willing to return to NIH for follow-up evaluation. Patients must have an outside general practitioner or endocrinologist. Patients with metastatic disease must also have an outside oncologist. Patients with PHEO/PGL will be accepted through clinician or self- referrals. Family Member of Patients Arm (Linkage Analysis) Participants are eligible for inclusion in this arm if they are: Adult family members of patients enrolled in this study: The index family member in this study has a suspected hereditary disorder of PHEO/PGL based on previous genetic testing and other suspicious hereditory patterns such as family history of multiple individuals with PHEO/PGL: early age of disease onset: multiplicity of primary tumors: recurrence, etc. and Signed informed consent form is required EXCLUSION CRITERIA: Potential patients will be excluded on the basis of one or more of the following: Pregnant (based on a pregnancy test done at the NIH at screening) or breastfeeding women Severe cardiac dysfunction Currently on dialysis A pregnancy test is performed in women of childbearing age (up to age 55) as a screening after consenting. The patient will be considered enrolled at consenting if outside of the boundaries for pregnancy concerns, or for females between the ages of 10-55 years, she will be enrolled on the protocol from a screening state after the pregnancy results are confirmed negative. If a patient is found to have a positive pregnancy test, her participation in this protocol will be temporarly excluded. The patient can enroll in the protocol when she is no longer pregnant or breastfeeding. External participants who will specifically sign the external consent form will need to provide verbal confirmation of lack of pregnancy or breastfeeding prior to enrollment at consenting. Research scans are contraindicated in patients with proven myelodysplastic syndrome. Patients who are not willing to return to the NIH (e.g., after surgery or an initial evaluation) for more than 2 years may be removed from the protocol. If the patient is eligible for a surgery and chooses to receive surgical intervention at a place outside of the NIH, his/her decision may affect future participation in the study. We also understand that due to extenuating circumstances the patient may need to pursue the surgery somewhere else. Under those circumstances, our team will provide a list of necessary criteria for continued followup (i.e. tissue transfer, follow-up tests, etc.). The patient will need to inform the research team ahead of time about the surgeon and institution that will be performing the surgery, so that the team can aid in facilitating the appropriate arrangements for tissue transfer. The patient will need to consult with the outside surgeon to develop a plan for sending a sample of tumor tissue to the NIH research team. If the surgeon is not consulted or the sample is not transferred, we may inform participants that their enrollment in the study may no longer be scientifically appropriate. In this case, the research team will work with the participant to develop a plan to obtain medical records to facilitate transfer of care in patient s preferred facility. Pregnant and breastfeeding women will be terminated fro m the protocol, if they are pregnant or breastfeeding, because their participation as a demographic is not essential to this study. The information we are seeking can be acquired from a cohort of non-pregnant patients. The exclusion of pregnant women does not preclude these patients from receiving appropriate care and management from an outside facility. SPECIFIC INCLUSION/EXCLUSION CRITERIA FOR IMAGING STUDIES WITHIN OUR PROTOCOL: In adult patients: Imaging studies are not done in patients that have the following exclusion criteria: Pregnant and breastfeeding women. A pregnancy test is performed in women of childbearing age (following NIH Clinical Center guidelines, currently ages 10-55 years). If after enrollment to this protocol, a patient is found to have a positive pregnancy test, her participation in this protocol will be terminated. They may reenrol once they are not pregnant or breastfeeding. Patients with a body weight exceeding the weight limitations of current Clinical Center PET/CT/MRI scanners or patients who are not able to enter the bore of PET/CT/MRI scanners due to increased BMI. Inability to lie still for the entire imaging time (e.g., cough, severe arthritis, etc.). Inability to complete the needed investigational and standard-of-care imaging examinations due to other reasons (e.g., severe claustrophobia, radiation phobia, etc.) Any additional medical conditions, serious illness or other extenuating circumstance that, in the opinion of the Principal Investigator, may significantly interfere with study compliance. Additionally, DCE-MRI is not done in patients with acute or chronic renal insufficiency since gadolinium chelate injection is contraindicated in those patients. Patients with impaired kidney function, based on the measurements of a creatinine clearance, will not undergo DCE-MRI. DCE-MRI is also not done in patients with severe claustrophobia or who have iron or metal in the MRI scan site, in patients with pacemakers or defibrillators or in patients with an allergy to gadolinium. Very rarely, gadolinium at the site of injection or the dosed limb can cause skin and soft tissue necrosis, thrombosis, fasciitis, and compartment syndrome requiring surgical intervention. In pediatric patients: Inclusion criteria for research PET imaging in children: Children over 10 years old with very high suspicion of sporadic or familial PHEO/PGL based oon at least one of the following The presence of new onset of symptoms typical of PHEO/PL such as hypertension or hypertensive episodes, sweating, headaches, pallor, palpitations, drug resistant hypertension, etc. Family history of PHEO/PGL or genetic mutations known to predispose individuals to develop these tumors The presence of a tumor on conventional imaging including ultrasound, CT and/or MRI or [123I]-MIBG or PET imaging not limited to [18F]-FDG. Children must give written informed assent and be willing to return to the NIH for follow-up. Female patients of childbearing age must have a negative pregnancy test prior to any treatment or test involving radioactivity or radiation exposure in accordance with NIH Clinical Center policies. They should be abstinent or use appropriate contraception while taking part in the study which involves radiation. Exclusion criteria for research PET imaging in children: Children of less than 10 years of age. Children with impaired mental capacity that precludes informed assent. Pregnant or breastfeeding female adolescents. Inability to lie still for the entire imaging time (e.g., cough, turbulent children, severe claustrophobia, etc.).