Difference in Efficacy Between Stem Cell Transplantation and Classical Therapy in Liver Cirrhosis Patients

Difference in Efficacy Between Stem Cell Transplantation and Classical Therapy in Liver Cirrhosis Patients

Difference in Efficacy Between Umbilical Cord Mesenchyma Stem Cell Transplantation and Classical Therapy in Liver Cirrhosis Patients

The current treatment methods of liver cirrhosis are limited ,including antiviral therapy,supportive therapy and liver transplantation. Antiviral therapy and Supportive therapy especially the regularly intravenous infusions of plasma or albumin are combined in the clinical classical therapy treatment. In the other hand,umbilical cord mesenchyma stem cell with self and directed differentiation capacity can effectively rescue experimental liver failure and contribute to liver regeneration, which suggests the feasibility of stem cell transplantation therapy. In this study, the safety and efficacy of umbilical cord mesenchyma stem cell transplantation through interventional procedures and classical therapy in patients liver cirrhosis will be evaluated and compared.

This study will includ two research centers, the number of patients in transplantation group will be 30, the number of patients in classical therapy group will be 30. All the inclusion and exclusion criteria will be same and the data analysis will be complete by the epidemiological commissioner.

umbilical cord mesenchyma stem cell transplantation through interventional procedures do in liver cirrhosis patients.

Antiviral therapy: lamivudine, 100 mg per day (oral dose); or adefovir dipivoxil 10 mg per day (oral dose); or grace entecavir 0.5-1mg per day (oral dose); or behalftelbivudine 600 mg per day (oral dose). Supportive therapy are allowed to use on patients not including intravenous infusions of plasma or albumin.

lamivudine, 100 mg per day (oral dose); or adefovir dipivoxil 10 mg per day (oral dose); or grace entecavir 0.5-1mg per day (oral dose); or behalftelbivudine 600 mg per day (oral dose).

alanine aminotransferase aspartate aminotransferase gamma-glutamyltransferase(GGT) alkaline phosphatase total bilirubin direct bilirubin The total bile acid (TBA) albumin the proportion of white balls

platelet count (PLT) mean platelet volume (MPV) platelet distribution width (PDW) platelet hematocrit (PCT) alpha feto protein (AFP)

prothrombin time (PT) activated partial thromboplastin time (APTT) fibrinogen (FIB) thrombin time (TT)

1)Portal vein diameter (Dpv) 2）Portal vein maximum velocity (Vmaxpv) 3）Portal vein blood flow per minute (Qpv) 4) The splenic vein diameter (Dsv) 5) Splenic vein maximum flow velocity (Vmaxsv) 6) Splenic vein blood flow per minute (Qsv)

Inclusion Criteria: Clinical diagnosis of liver cirrhosis; Without hepatic encephalopathy; No ascites or have easily dissipated ascites; Value of bilirubin is less than 100; Value of albumin is greater than 16 g / L; Prothrombin time is less than 21 seconds; Exclusion Criteria: Severe cardiovascular disease, and immunocompromised patients; Patients with localized lesions affecting graft infection; Coagulation disorders; Liver nodules more than 2cm or Liver cancer.