Different Kinds of Acupuncture Treatment for Knee Osteoarthritis
Knee Osteoarthritis
About this trial
This is an interventional treatment trial for Knee Osteoarthritis focused on measuring KOA, Acupuncture treatment, Multi-center RCT
Eligibility Criteria
Inclusion Criteria:
- Meet the Clinical Classification Criteria for Osteoarthritis of the Knee, diagnosed by specialist.
- Aged 40-75 years old;
- History of chronic knee pain for more than 3 months, and complain of knee pain on most days of the past month;
- Kellgren and Lawrence Grades 1-3;
- With related knee pain in one or both knees rated > 4 cm on a 10 cm Visual Analog Scale(VAS) (VAS:0 to 10)
- Who volunteer to participate and sign the consent form .
Exclusion Criteria:
- Knee osteoarthritis patients with gout, infection, tumor, autoimmune diseases, trauma or other causes of knee pain or knee deformities;
- Patients who have local skin damage, poor skin conditions or coagulant dysfunction and patients who are not suitable for acupuncture;
- Patients who are accompanied with serious medical problems or mental disorders, cognitive dysfunction,disorders of shallow sensation or who cannot cooperate with the treatment;
- Patients who have received acupuncture or needle knife in the past month;
- Other patients who are not suitable for acupuncture treatment.
Sites / Locations
- The third affiliated hospital of Zhejiang CMU
Arms of the Study
Arm 1
Arm 2
Arm 3
Arm 4
Arm 5
Arm 6
Experimental
Experimental
Experimental
Experimental
Sham Comparator
Active Comparator
Acupuncture group
Electro-acupuncture group
Moxibustion group
Warm-needling group
Sham-needle group
Celebrex group
When recruited from six centers,the participant will be randomized to six groups .In acupuncture group participant will receive four-week acupuncture treatment(three times a week )continuously for 4 weeks,12 treatments in total. The follow-up period is six months.
When recruited from six centers,the participant will be randomized to six groups. In this group participant receive four-week electro-acupuncture treatment(three times a week )continuously for 4 weeks,12 treatments in total. The follow-up period is six months.
When recruited from six centers,the participant will be randomized to six groups. In this group participant receive four-week moxibustion treatment (three times a week )continuously for 4 weeks,12 treatments in total. The follow-up period is six months.
When recruited from six centers,the participant will be randomized to six groups. In this group participant receive four-week warm-needling treatment (three times a week )continuously for 4 weeks,12 treatments in total. The follow-up period is six months.
When recruited from six centers,the participant will be randomized to six groups.In this group participant receive four-week sham acupuncture treatment (three times a week )continuously for 4 weeks,12 treatments in total. The follow-up period is six months.
When recruited from six centers,the participant will be randomized to six groups . In this group participant will receive Celebrex (Celebrex, Capsules, Pfizer Pharmaceuticals Ltd)treatment, which will be applied 1 time daily(one time oral 0.2g) for 4 weeks. The follow-up period is six months.