Direct and Indirect Protection by Influenza Vaccine Given to Children in India
Influenza
About this trial
This is an interventional prevention trial for Influenza focused on measuring Influenza, India, Children, Trivalent Influenza Vaccine (TIV), Inactivated poliovirus vaccine (IPV), Direct vaccine effectiveness, Indirect vaccine effectiveness
Eligibility Criteria
Inclusion Criteria:
- Inclusion in either vaccine group (TIV or IPV) will require ages 6 months through 10 years of age.
- All individuals in enrolled households will be eligible for enrollment into surveillance arm.
Exclusion Criteria:
- Exclusion criteria from the vaccine groups includes known allergy to eggs, or hypersensitivity to other components of a vaccine (streptomycin, neomycin, and polymyxin B)
Sites / Locations
- Comprehensive Rural Health Services Project (CRHSP)
Arms of the Study
Arm 1
Arm 2
Arm 3
Active Comparator
Experimental
No Intervention
Inactivated Polio Vaccine (IPV)
Inactivated Trivalent Influenza Vaccine
Surveillance arm
Inactivated trivalent poliovirus vaccine (IPV) age Dose # doses/year 1 # doses year 2 and 3 6 mo -8y 0.5 ml 2 1 9-10 y 0.5 ml 1 1
Inactivated split virion trivalent influenza vaccine (TIV) age Dose # doses year 1 # doses year 2 and 3 6-35 mo 0.25 ml 2 1 3-8 y 0.5 ml 2 1 9-10 y 0.5 ml 1 1
Those ineligible for vaccination will be enrolled for febrile acute respiratory illness (FARI) surveillance to assess indirect effects of vaccination in household members.