Direct Endovascular Treatment Versus Bridging Treatment In Basilar Artery Occlusive Stroke (BEST-BAO)
Acute Ischemic Stroke, Basilar Artery Occlusion, Thrombosis
About this trial
This is an interventional treatment trial for Acute Ischemic Stroke focused on measuring Endovascular treatment, Alteplase, Acute ischemic stroke, Basilar artery occlusion, Intravenous thrombosis
Eligibility Criteria
Inclusion Criteria: A clinical diagnosis of acute ischemic stroke (AIS); Caused by basilar artery occlusion (BAO) confirmed by CTA, MRA, or DSA; CT or MRI ruling out intracranial hemorrhage; Eligible for intravenous thrombolysis (IVT) and endovascular treatment (EVT) (within 4.5 hours after symptom onset); A score of at least 6 on the NIHSS score; Age of 18 years or older; Written informed consent. Exclusion Criteria: Pre-stroke disability which interferes with the assessment of functional outcome at 90 days, i.e. mRS >2 Any contra-indication for intravenous thrombolysis (IVT), according to guidelines of the American Heart Association, i.e.: Arterial blood pressure exceeding 185/110 mmHg Blood glucose less than 2.7 or over 22.2 mmol/L Cerebral infarction in the previous 6 weeks with residual neurological deficit or signs of recent infarction on neuro-imaging Serious head trauma in the previous 3 months Major surgery or serious trauma in the previous 2 weeks Gastrointestinal or urinary tract hemorrhage in the previous 3 weeks Previous intracerebral hemorrhage Use of anticoagulant with INR exceeding 1.7 Known thrombocyte count less than 100 x 10^9/L Treatment with direct thrombin or factor X inhibitors Treatment with heparin (APTT exceeds the upper limit of normal value) in the previous 48 hours.
Sites / Locations
- The First Affiliated Hospital of University of Science and Technology of China (Anhui Provincial Hospital)
- Banan Hospital Affiliated to Chongqing Medical University
- Chongqing Sanbo Chang'an Hospital
- Hechuan District People's Hospital
- Liangping District People's Hospital
- The First People's Hospital of Liangjiang New Area
- Yubei District People's Hospital
- The Fifth People's Hospital Affiliated to Southern Medical University
- Qiandongnan Miao and Dong Autonomous Prefecture People's Hospital
- Tongren People's Hospital
- Qianxinan Buyei and Miao Autonomous Prefecture People's Hospital
- Nanyang Central Hospital
- Zhuzhou Central Hospital
- Bazhong Central Hospital
- Chengdu Third People's Hospital
- Affiliated Hospital of Chengdu Medical College
- Chengdu Fifth People's Hospital
- Chengdu First People's Hospital
- Chengdu Second People's Hospital
- Chongzhou People's Hospital
- Dayi County People's Hospital
- Western Theater General Hospital
- Deyang People's Hospital
- Guang'an Central Hospital
- Guangyuan Central Hospital
- Guangyuan First People's Hospital
- Affiliated Hospital of Southwest Medical University
- Mianyang 404 Hospital
- Mianyang Central Hospital
- Mianyang Third People's Hospital
- Affiliated Hospital of North Sichuan Medical College
- Langzhong People's Hospital
- Nanchong Central Hospital
- Yilong County People's Hospital
- Neijiang Second People's Hospital
- Panzhihua Central Hospital
- Suining Central Hospital
- Suining First People's Hospital
- Ya'an People's Hospital
- Yibin First People's Hospital
- Yibin Second People's Hospital
- Zigong First People's Hospital
- Zigong Third People's Hospital
- Ziyang First People's Hospital
- Kashgar First People's Hospital
Arms of the Study
Arm 1
Arm 2
Sham Comparator
Active Comparator
Direct endovascular treatment group
Bridging treatment group
Direct endovascular treatment (EVT) without intravenous thrombolysis (IVT)
Intravenous thrombolysis (IVT) followed by endovascular treatment (EVT)