Docetaxel and Gemcitabine Compared With Docetaxel and Cisplatin in Treating Patients With Metastatic or Locally Advanced Pancreatic Cancer
Pancreatic Cancer
About this trial
This is an interventional treatment trial for Pancreatic Cancer focused on measuring stage III pancreatic cancer, recurrent pancreatic cancer, adenocarcinoma of the pancreas, stage IV pancreatic cancer
Eligibility Criteria
DISEASE CHARACTERISTICS: Histologically or cytologically confirmed metastatic or locoregionally advanced (with metastatic lymph nodes) unresectable adenocarcinoma of the exocrine pancreas Bidimensionally measurable disease outside previously irradiated fields No CNS involvement or leptomeningeal disease PATIENT CHARACTERISTICS: Age: 18 and over Performance status: WHO 0-1 Life expectancy: Not specified Hematopoietic: WBC at least 3,000/mm3 Platelet count at least 100,000/mm3 Hepatic: Bilirubin less than 1.5 times the upper limit of normal (ULN) Renal: Creatinine no greater than ULN Other: No prior second malignancy in the past 10 years except carcinoma in situ of the cervix or basal or squamous cell carcinoma of the skin No psychological, familial, sociological, or geographical condition that precludes study compliance Not pregnant or nursing Fertile patients must use effective contraception PRIOR CONCURRENT THERAPY: Biologic therapy: No prior immunotherapy Chemotherapy: No prior chemotherapy Endocrine therapy: Not specified Radiotherapy: Concurrent radiotherapy allowed if indicator lesions not included in irradiated field See Disease Characteristics Surgery: Not specified Other: No concurrent investigational drugs
Sites / Locations
- Institut Jules Bordet
- Hopital Universitaire Erasme
- U.Z. Gasthuisberg
- National Cancer Institute of Egypt
- CHU Ambroise Pare
- Centre Alexis Vautrin
- Institut Gustave Roussy
- Klinikum St. Marien
- Universitaetsklinik und Strahlenklinik - Essen
- Klinikum der J.W. Goethe Universitaet
- Marien Hospital
- Hermann-Holthusen Institute for Radiotherapy
- Medizinische Hochschule Hannover
- Praxis Innere Medizin
- Klinikum der Universitaet Ulm
- Saint Laurentius Ziekenhuis
- Maria Sklodowska-Curie Memorial Cancer Center and Institute of Oncology
- Dokuz Eylul University School of Medicine
- Beatson Oncology Centre