Docetaxel and Oxaliplatin in Treating Patients With Stage III or Stage IV Ovarian Epithelial Cancer
Ovarian Cancer
About this trial
This is an interventional treatment trial for Ovarian Cancer focused on measuring recurrent ovarian epithelial cancer, stage III ovarian epithelial cancer, stage IV ovarian epithelial cancer
Eligibility Criteria
DISEASE CHARACTERISTICS: Histologically confirmed ovarian epithelial cancer Stage III or IV disease Metastatic peritoneal, lymphatic, or visceral disease Measurable or evaluable disease Previously untreated disease OR relapsed disease more than 6 months after the completion of a platinum-containing chemotherapy regimen No symptomatic brain metastases PATIENT CHARACTERISTICS: Age 18 to 75 Performance status WHO 0-2 (0 in patients 70 to 75 years of age) Life expectancy Not specified Hematopoietic Absolute neutrophil count at least 1,500/mm^3 Platelet count at least 100,000/mm^3 Hepatic Bilirubin no greater than 1.25 times upper limit of normal (ULN) AST and ALT no greater than 3 times ULN Alkaline phosphatase less than 2.5 times ULN Renal Creatinine no greater than 1.4 mg/dL Other No serious uncontrolled infection No intolerance to polysorbate 80 No peripheral neuropathy greater than grade 1 No neurological or mental disease that would preclude study participation No other prior malignancy except curatively treated basal cell skin cancer or carcinoma in situ of the cervix PRIOR CONCURRENT THERAPY: Biologic therapy Not specified Chemotherapy See Disease Characteristics More than 4 weeks since prior chemotherapy No more than 1 prior chemotherapy regimen No prior oxaliplatin or docetaxel Endocrine therapy Not specified Radiotherapy More than 4 weeks since prior radiotherapy Surgery Not specified Other More than 28 days since prior participation in another clinical study No other concurrent anticancer treatment
Sites / Locations
- Intercommunal Hospital
- Hopital Saint Antoine
- Hopital Tenon
- Polyclinique De Courlancy
- C.H. Senlis