Docetaxel and Vinorelbine Plus Filgrastim in Treating Patients With Stage IIIB or Stage IV Non-Small Cell Lung Cancer
Lung Cancer

About this trial
This is an interventional treatment trial for Lung Cancer focused on measuring stage IIIB non-small cell lung cancer, stage IV non-small cell lung cancer
Eligibility Criteria
DISEASE CHARACTERISTICS: Histologically or cytologically confirmed stage IIIB or IV non-small cell lung cancer Bidimensionally measurable or evaluable disease No symptomatic brain metastases PATIENT CHARACTERISTICS: Age: Over 18 Performance status: Karnofsky 70-100% Life expectancy: Greater than 2 months Hematopoietic: Absolute neutrophil count at least 2,000/mm3 Platelet count at least 100,000/mm3 Hepatic: AST and ALT no greater than 1.5 times upper limit of normal (ULN) Bilirubin no greater than ULN Renal: Creatinine no greater than 2.0 mg/dL Cardiovascular: No uncontrolled hypertension, unstable angina, congestive heart failure, or atrial or ventricular arrhythmias At least 6 months since prior myocardial infarction Other: Not pregnant or nursing Negative pregnancy test Fertile patients must use effective contraception HIV negative No poorly controlled diabetes No known allergy to E. coli derivatives or any products to be administered No other prior malignancy within the past 5 years except surgically cured basal cell skin cancer or carcinoma in situ of the cervix No active infection or fever Not previously entered in this study PRIOR CONCURRENT THERAPY: Biologic therapy: No other concurrent hematopoietic growth factors Chemotherapy: No prior chemotherapy Endocrine therapy: Not specified Radiotherapy: At least 2 weeks since prior radiotherapy and recovered Surgery: At least 2 weeks since prior major thoracic or abdominal surgery and recovered At least 6 months since prior coronary angioplasty Other: At least 30 days since prior investigational agents No other concurrent investigational agent No prophylactic acetaminophen for fever
Sites / Locations
- Gould Medical Group
- Sibley Memorial Hospital
- Veterans Affairs Medical Center - Washington, DC
- Georgia Cancer Treatment Center, P.C.
- Oncology and Hematology Associates
- Veterans Affairs Medical Center - Brooklyn
- Hematology-Oncology Associates of Rockland, P.C.
- New York Medical College
- Cleveland Clinic Taussig Cancer Center
- Community Oncology Group
- CCOP - Dayton
- CCOP - Toledo Community Hospital Oncology Program
- Charleston Hematology-Oncology, P.A.
- Trident Palmetto Hematology/Oncology
- Boston Baskin Cancer Group, University Tennessee Oncology/Hematology Group
- Texas Cancer Care
- University of Texas Medical Branch
- Hematology & Oncology Associates of Virginia
- Morgantown Internal Medicine Group