Dose-escalating Safety Study in Subjects on Stable Statin Therapy

Inclusion Criteria: On a stable dose of >/= 40 mg Simvastatin or atorvastatin daily for >/= 3 months prior to baseline and expected to remain on this dose for the remainder of the study LDL-cholesterol between 2.60 and 5.70 mmol/L (100 and 220 mg/dL), inclusive at screening Females not of childbearing potential. Exclusion Criteria: History of CHD or CHD-equivalent (such as diabetes mellitus, or another clinical form of atherosclerotic disease, e.g., peripheral arterial disease, abdominal aortic aneurysm, or symptomatic carotid artery disease) Fasting triglyceride >2.26 mmol/L (200 mg/dL) at screening Any uncontrolled medical/surgical/psychiatric condition, including conditions that may predispose to secondary hypercholesterolemia Current diagnosis or known history of complement deficiency or abnormality A positive hepatitis B surface antigen or hepatitis C antibody, or a known positive HIV status Current diagnosis or known history of liver disease, or has an ALT >ULN at screening Known history of fibromyalgia, myopathy, myositis, rhabdomyolysis, any unexplained muscle pain, or has a CPK >ULN at screening Malignancy within 5 years, except for basal or squamous cell carcinoma of the skin that has been adequately treated The advisability of a subject taking any prescription medication (apart from simvastatin or atorvastatin) within 6 weeks prior to screening should be discussed with the Isis Medical Monitor Subject unwilling to discontinue taking alternative/herbal medication for the duration of the study History of drug abuse within 2 years of screening Subject unwilling to limit alcohol consumption for the duration of the study: male subjects to a maximum of 3 drinks (30 g) per day, and <12 drinks (120 g) per week; female subjects to a maximum of 2 drinks (20 g) per day, and <8 drinks (80 g) per week Known allergy or hypersensitivity to simvastatin Undergoing or has undergone treatment with another investigational drug, biologic agent, or device within 3 months, or 3 half lives, prior to screening, whichever is longer