Dose-finding Study to Investigate the Safety and Immunogenicity of Two Vaccinations With FSME IMMUN NEW in Healthy Volunteers Aged 1 to 6 Years.

Inclusion Criteria: Male and female children will be eligible for participation in this study if: they are 1 year (from the 1st birthday) to 6 years (to the last day before the 6th birthday) old; they are clinically healthy; their legal representative understands the nature of the study, agrees to its provisions and gives written informed consent; their legal representative agrees to keep a Volunteer Diary. Exclusion Criteria: Children will be excluded from participation in this study if they: have a history of any previous TBE vaccination; have a history of TBE infection or show evidence of a latent TBE infection (as demonstrated by screening ELISA > 126 VIEU/ml and / or neutralization test > 1:10); have a history of allergic reactions, in particular to one of the components of the vaccine; have received antipyretics within 4 hours prior to the first TBE vaccination; suffer from a disease that cannot be effectively treated or stabilized; suffer from a disease (e.g. autoimmune disease) or are undergoing a form of treatment that can be expected to influence immunological functions; suffer from chronic, degenerative and / or inflammatory disease of the central nervous system; are known to be HIV positive (a special HIV test is not required for the purpose of the study); suffer from a febrile illness at study entry; have a history of vaccination against yellow fever and / or Japanese B-encephalitis; are participating simultaneously in another clinical trial.