Drug Therapy for Alcohol Dependence in Alaska Natives (Naltrexone/Sertraline)

Inclusion Criteria: Alaska Native having biological Alaska Native ancestry. Meets criteria for alcohol dependence. Prior to entering the study must be abstinent between 3 and 14 days and have a withdrawal assessment. Stable residence to ensure that subjects can be located during the study. Exclusion Criteria: Currently meets criteria for abuse or dependence on substances other than alcohol or nicotine. Current use of disulfiram. Psychotic or otherwise severely psychiatrically disabled. Use of other psychotropic medications including antidepressants and anxiolytics. Medical conditions that would not permit the use of sertraline or naltrexone, such as a history of unstable or severe hepatic, cardiovascular, metabolic, endocrine, gastrointestinal or kidney disease. Hepatocellular disease or elevated bilirubin levels. Females who are pregnant, nursing, or not using a reliable method of birth control. Probation or parole requirements that might interfere with participation in the study. Involvement in alcohol treatment other than provided by the study or AA. Use of monoamine oxidase inhibitors in the past month. Current use of Type 1C antiarrhythmics propafenone and flecainide.