Dumping Syndrome and Esophageal Atresia (DUMTORING)

Groupement Interrégional de Recherche Clinique et d'Innovation, french patient association for oesophageal atresia AFAO

Dumping syndrome (DS) is frequent in oesophageal atresia (29%). In causing hypoglycaemia, it can be dangerous for neonates. Mechanisms of DS are actually partialy understood. This is also an affection difficult to diagnose, because it only occurs after meals and can be inconstantly present. To date, their is only symptomatic treatment for DS. This study aims to understand its pathological mechanisms so as to better treat it and avoid its consequences. Oesophageal atresia patients enrolled in this study will benefit from a continuous glycemic monitoring, a continuous cardiac monitoring, and an a gastric emptying scintigraphy at the age of 3 months

All children born at the Lille University Hospital during the investigation period with esophageal atresia type III or IV

Fasting administration of a Technecium-labelled milk bottle and quantification of the remaining radioactivity by a camera every 30 minutes for 4 hours.

Composite criteria: association between abnormal glycaemia (high or low) and variations of cardiac frequency

Composite criteria: association between abnormal glycaemia (high or low) and abnormal gastric emptying study

Inclusion Criteria: Patients operated at birth for Oesophageal atresia type C Aged from 2 to 3 months at inclusion Off prokinetic treatment (suspended for at least 72 hours) before monitoring Exclusion Criteria: History of dumping syndrome of other cause (microgastria, fundoplication, dysautonomia..) History of any disease that can modify glycemic regulation (hyperinsulinism, neonatal diabete) Treatment that can modify gastric motility