E-Cigarette Aerosol, Conventional Cigarette Smoke, and Myocardial Perfusion
Coronary Artery Disease, Myocardial Perfusion
About this trial
This is an interventional other trial for Coronary Artery Disease focused on measuring Myocardial perfusion, Electronic cigarettes, Cigarettes, Cigarette smoking
Eligibility Criteria
Inclusion Criteria:
- Age 18-49
- Regular cigarette smoker defined as at least 1 pack year and ≥ 5/day
- E-cigarette smoker defined as ≥ 1/week in the last 6 months.
Exclusion Criteria:
- Sub-optimal echocardiography images as determined by the sonographer and/or investigators.
- History of cardiopulmonary (including asthma or use of inhalers),
- History of diabetes or dyslipidemia
- History of psychiatric illness
- Blood Pressure > 140/90
- Body Mass Index ≤ 18.5 or ≥ 30 kg•m2
- Evidence of any of the above by physical examination, Electrocardiogram (ECG) or echocardiogram
- Resting Heart Rate > 100 beats/min
- Cardiac rhythm disorder, specifically: rhythm other than sinus, Supraventricular Tachycardia (SVT), atrial fibrillation, ventricular tachycardia
- Use of prescription medication except oral contraceptive pills
- History of illicit drug use (self-stated)
- Pregnant
- Any other condition(s) deemed by the physician investigators that put subjects at risk for participating in the study
Sites / Locations
- Cedars-Sinai Medical Center
Arms of the Study
Arm 1
Arm 2
Arm 3
Arm 4
Experimental
Experimental
Experimental
Experimental
Cigarettes
E-cigarettes (nicotine free e-liquid)
E-cigarettes (low nicotine e-liquid)
E-cigarettes (high nicotine e-liquid)
Healthy chronic dual cigarette and e-cigarette smokers will undergo myocardial contrast echocardiography before and after smoking two standard cigarettes
Healthy chronic dual cigarette and e-cigarette smokers will undergo myocardial contrast echocardiography before and after smoking nicotine free e-cigarette liquid.
Healthy chronic dual cigarette and e-cigarette smokers will undergo myocardial contrast echocardiography before and after smoking low concentration(4-6 mg/mL) e-cigarette liquid.
Healthy chronic dual cigarette and e-cigarette smokers will undergo myocardial contrast echocardiography before and after smoking high concentration (18-24 mg/mL) e-cigarette liquid.