Effect of Aerobic Training and Moringa Oleifera on Dyslipidemia and Cardiac Endurance
Primary Purpose
Dyslipidemias
Status
Unknown status
Phase
Not Applicable
Locations
Study Type
Interventional
Intervention
Aerobic training and Moringa Oleifera
Sponsored by
About this trial
This is an interventional health services research trial for Dyslipidemias focused on measuring Aerobic training, Moringa, Cardioprotection
Eligibility Criteria
Inclusion Criteria:
- Healthy and no medical conditions.
- LDL level should be 160-189 mg/dl
- HDL level should be < 40 mg/dl
- Tri glyceride level should be 200-499 mg/dl
- Total cholesterol level should be > 200 mg/dl).
- Beep Test score should be less than 10.5 or less than 40% vo2 max
Exclusion Criteria:
- Any disease condition as anemia, physical injuries, chronic disease
- Not capable of doing aerobic training
Sites / Locations
Arms of the Study
Arm 1
Arm 2
Arm 3
Arm 4
Arm Type
Experimental
Experimental
Experimental
No Intervention
Arm Label
Moringa Group
Aerobic training Group
Moringa and Aerobic training
Control Group (T4)
Arm Description
Participants will receive 5-7g of moringa diet daily for 6 weeks.
Participants will receive 5-7g of moringa diet daily and will do 30 minutes of aerobic training daily for 6 weeks.
Participants will do 30 minutes of aerobic training daily for 6 weeks
Participants will not recieve any treatment
Outcomes
Primary Outcome Measures
Positive effect of aerobic training and Moringa Oleifera on dyslipidemia and cardiac endurance
Change in level of HDL, LDL and triglyceride, impact on cardiac endurance
Secondary Outcome Measures
Full Information
NCT ID
NCT04164771
First Posted
November 7, 2019
Last Updated
December 16, 2019
Sponsor
Aga Khan University
Collaborators
Muhammad Safdar Ali
1. Study Identification
Unique Protocol Identification Number
NCT04164771
Brief Title
Effect of Aerobic Training and Moringa Oleifera on Dyslipidemia and Cardiac Endurance
Official Title
Effect of Aerobic Training and Moringa Oleifera on Dyslipidemia and Cardiac Endurance
Study Type
Interventional
2. Study Status
Record Verification Date
December 2019
Overall Recruitment Status
Unknown status
Study Start Date
February 2020 (Anticipated)
Primary Completion Date
April 2020 (Anticipated)
Study Completion Date
July 2020 (Anticipated)
3. Sponsor/Collaborators
Responsible Party, by Official Title
Principal Investigator
Name of the Sponsor
Aga Khan University
Collaborators
Muhammad Safdar Ali
4. Oversight
Studies a U.S. FDA-regulated Drug Product
No
Studies a U.S. FDA-regulated Device Product
No
Data Monitoring Committee
No
5. Study Description
Brief Summary
Aerobic training is essential for maintaining and improving physical performance and has a positive effect on physiological functions as well as anthropometric characteristics. It also has positive effect on cardiovascular health and carries a number of beneficial effects on the whole body functions and systems. Aerobic training can also decrease the risk of heart disease in the individual's life.The Moringa leaves are the rich source of minerals, vitamins and other essential phytochemicals. Moringa leave have found to be very effective in many disease particularly diabetic, blood pressure, dyslipidemia and cancer.
Detailed Description
Aerobic training is an important component for health in daily life as well as sports performance. Aerobic training improves overall health, reduces body fat, maintain body weight, resting blood pressure (systolic and diastolic), maximal oxygen consumption adequate blood supply and provision of oxygen to the body muscles .The studies reveal that aerobic training is valuable for improving cardiovascular health, fitness and quality of life. On account of lack of aerobic engagement around 17 % of the population suffer from heart related ailment, 12 % from diabetes and 10 % from breast cancer. American College of Sports Medicine suggested that 30 minutes of aerobic workout has progressive effects on physical fitness and especially on chronic diseases. Physically fit individuals have got the potential to affectively cope with stress and anxiety and coronary arteries diseases. Aerobic training can raise maximal oxygen uptake, which means body adapts to use oxygen more efficiently during physical activities. Resultantly, the heart becomes efficient and stronger; meaning that the heart doesn't have to work hard to pump blood in resting position. Aerobic training decreases resting heart rate and may increase blood volume and blood plasma. Moringa Oleifera a plant from the family Moringacea, its products are used as a health supplement introduced in Africa and south Asian countries to cure many diseases and improve health status . Moringa leaves are rich source of vitamins and protein. The Moringa oleifera leaves, flowers, seeds and pods are commonly used as vegetables diet in different regions of south Asia. Moringa plant products are sources of vitamin A, b, C and proteins, including the essential amino acids. Moringa Oleifera leaves can be merged in the feed of birds, animals and human which provide wonderful source of protein other than expensive ingredients. The Moringa oil is used in cooking products as well as for lubrication. There are scientific indications that Moringa Oleifera holds therapeutic potential for hyperlipidemia, diabetes and cardiovascular diseases. The use of herbal supplements has increased rapidly during the first decade of the twentieth century. The nutrients of Moringa are considered to be useful for disorders including skin disease, malnutrition and sexual problem.Different experimental studies has described that Moringa oleifera leaves have therapeutic potential for chronic hyperglycemia and dyslipidemia . Moringa Oleifera is used as a hypolipidemic medication to improve the lipid profile of rats fed on atherogenic diet. Moringa Oleifera intake is more effective in prevention than in treatment of hyperlipidemia.It is documented that overuse of Moringa supplements can cause high increase of iron. Hence, a daily 70 g quantity of Moringa is recommended to be batter and preventive for accumulation of nutrients.This research study is due to be conducted to determine the effect of aerobic training and Moringa Oleifera on dyslipidemia and cardiac endurance
6. Conditions and Keywords
Primary Disease or Condition Being Studied in the Trial, or the Focus of the Study
Dyslipidemias
Keywords
Aerobic training, Moringa, Cardioprotection
7. Study Design
Primary Purpose
Health Services Research
Study Phase
Not Applicable
Interventional Study Model
Parallel Assignment
Masking
None (Open Label)
Allocation
Randomized
Enrollment
120 (Anticipated)
8. Arms, Groups, and Interventions
Arm Title
Moringa Group
Arm Type
Experimental
Arm Description
Participants will receive 5-7g of moringa diet daily for 6 weeks.
Arm Title
Aerobic training Group
Arm Type
Experimental
Arm Description
Participants will receive 5-7g of moringa diet daily and will do 30 minutes of aerobic training daily for 6 weeks.
Arm Title
Moringa and Aerobic training
Arm Type
Experimental
Arm Description
Participants will do 30 minutes of aerobic training daily for 6 weeks
Arm Title
Control Group (T4)
Arm Type
No Intervention
Arm Description
Participants will not recieve any treatment
Intervention Type
Other
Intervention Name(s)
Aerobic training and Moringa Oleifera
Intervention Description
Aerobic exercises/training refers to any type of rhythmic, continuous physical activities that use large group of muscles like walking, running, cycling, and swimming consuming additional amount of energy while Moringa Oleifera a plant from the family Moringacea, its products are used as a health supplement introduced in Africa and south Asian countries to cure many diseases and improve health status
Primary Outcome Measure Information:
Title
Positive effect of aerobic training and Moringa Oleifera on dyslipidemia and cardiac endurance
Description
Change in level of HDL, LDL and triglyceride, impact on cardiac endurance
Time Frame
6 weeks
10. Eligibility
Sex
Male
Gender Based
Yes
Minimum Age & Unit of Time
20 Years
Maximum Age & Unit of Time
50 Years
Accepts Healthy Volunteers
Accepts Healthy Volunteers
Eligibility Criteria
Inclusion Criteria:
Healthy and no medical conditions.
LDL level should be 160-189 mg/dl
HDL level should be < 40 mg/dl
Tri glyceride level should be 200-499 mg/dl
Total cholesterol level should be > 200 mg/dl).
Beep Test score should be less than 10.5 or less than 40% vo2 max
Exclusion Criteria:
Any disease condition as anemia, physical injuries, chronic disease
Not capable of doing aerobic training
Central Contact Person:
First Name & Middle Initial & Last Name or Official Title & Degree
Naseer Ahmed, Ph.D
Phone
03333382013
Ext
4465
Email
dr.naseer99@gmail.com
First Name & Middle Initial & Last Name or Official Title & Degree
Javeria Farooq, M.Phil
Phone
03343585849
Email
javeria.farooq@aku.edu
Overall Study Officials:
First Name & Middle Initial & Last Name & Degree
Naseer Ahmed, Ph.D
Organizational Affiliation
Agha Khan Hospital
Official's Role
Principal Investigator
12. IPD Sharing Statement
Plan to Share IPD
No
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Effect of Aerobic Training and Moringa Oleifera on Dyslipidemia and Cardiac Endurance
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