Effect of Blueberries on Bone Turnover
Osteoporosis, Postmenopausal, Bone Loss, Age-related
About this trial
This is an interventional prevention trial for Osteoporosis, Postmenopausal focused on measuring Bone Health, Calcium, Osteoporosis, Polyphenolics
Eligibility Criteria
Inclusion Criteria:
- Female subject is healthy
- Subject is > 4 years past the onset of natural menopause or total hysterectomy
Exclusion Criteria:
- History of metabolic bone disease or low trauma fractures;
- Subject taking osteoporosis treatment drugs or glucocorticoids within 6 months of the beginning of the study;
- Subjects taking bisphosphonates within 2 years of the beginning of the study;
- History of cancer, thromboembolisms, clotting disorders, uncontrolled hypertension, abnormal thyroid function, malabsorption syndrome, seizure disorders, or heart attack;
- BMI > 35 kg/m2;
- Subjects who will not comply with study interventions ;
- Subjects who will not stop taking natural product supplements of their own selection.
Sites / Locations
- Department of Nutrition Science Purdue University
Arms of the Study
Arm 1
Arm 2
Arm 3
Arm 4
Placebo Comparator
Active Comparator
Active Comparator
Active Comparator
Blueberry baseline
Blueberry Low
Blueberry Medium
Blueberry High
No blueberry products provided as part of the usual dietary intake
One blueberry product per day containing an equivalent of 0.75 cups of fresh blueberries provided as part of usual dietary intake for 42 days
Two blueberry products per day containing an equivalent of 1.5 cups of fresh blueberries provided as part of usual dietary intake for 42 days
Four blueberry products per day containing an equivalent of 3 cups of fresh blueberries provided as part of usual dietary intake for 42 days