Effect of Dapagliflozin on Microvascular Function in Women With Symptoms of Coronary Artery Disease (SMILE)

Inclusion Criteria: Willing to provide written informed consent. Signs and symptoms of suspected ischemia that prompted referral for further evaluation by cardiac catheterization or coronary computed tomography within two years of consent. No evidence of obstructive epicardial coronary artery disease (stenosis >50%) of a major epicardial vessel (>3mm) or a fractional flow reserve >0.80 by invasive catheterization or coronary computed tomography. (Participants who have not undergone cardiac catheterization or coronary angiogram within the last 2 years for their clinical care will be screened with computed angiogram of the coronary arteries to confirm eligibility). Estimated glomerular filtration rate ≥30ml/min/1.73m2 at enrollment For subjects having a history of type 2 diabetes mellitus: approval of diabetes care/prescribing provider Exclusion Criteria: History of non-ischemic cardiomyopathy with left ventricular ejection fraction <40% or hypertrophic cardiomyopathy. History of congestive heart failure, severe pulmonary disease, liver disease History of Acute coronary syndrome within previous 30 days Stroke within the last 180 days or intracranial hemorrhage at any time. Severe Valvular disease Life expectancy <3 years, due to non-cardiovascular comorbidity. Pregnancy or women who are breast-feeding Type 1 diabetes mellitus History of diabetic ketoacidosis in subjects with Type 2 Diabetes Mellitus Symptomatic hypotension or systolic blood pressure <95 mmHg on 2 consecutive measurements Active malignancy requiring treatment at the time of visit Severe, unstable, or rapidly progressing renal disease at the time of randomization History of recurrent urinary tract, bladder, or kidney infections