Effect of GOS Supplementation on Amoxicillin-treated Gut Microbiota From Healthy Adults (GOS)
Colonic Diseases [C06.405.469.158]
About this trial
This is an interventional treatment trial for Colonic Diseases [C06.405.469.158] focused on measuring intestinal microbiota composition, intestinal microbiota activity, gastro-intestinal complains
Eligibility Criteria
Inclusion Criteria:
- Age: 18-40 *
- BMI: 18.5-25 kg/m2
- Stable weight over the last 6 months
- Western diet
- Availability of information about birth by caesarean section and breast-feeding
- Regular defecation (~1day)
- Healthy as judge by the participant himself
- Having signed the informed consent form
Exclusion Criteria:
- Smoking or drug use
- Pregnant (include planning to be or gave birth in the last 6 months) or lactating woman
- Using contraceptive pill
- Gastro-intestinal diseases (e.g. irritable bowel syndrome, inflammatory bowel disease)
- Traveling to an Asian, African or south American country < 6 months before the study
- Hypersensitivity or food allergy for products used in this study (e.g. Lactose, Penicillin)
- Having hepatic disease and renal failure
- Using medication other than paracetamol, acetylsalicylic acid (aspirin), hay fever, asthma
- Not willing to have the family doctor be informed about participation to the study.
- Antibiotic use < 3 months before the study
- More than 3 antibiotic treatments in the last 2 years.
- Probiotic or prebiotic use < 1 month before the study*
Sites / Locations
- Laboratory of Food Chemistry
Arms of the Study
Arm 1
Arm 2
Placebo Comparator
Placebo Comparator
GOS addition
placebo (maltodextrine)
All subjects will receive amoxicillin (375 mg 3x per day) for 5 days. Group 1 receives a drink with GOS (2,5 g 3x per day) simultaneously to the antibiotic for 5 days and after the antibiotic treatment for another 7 days. The intervention products should be consumed at breakfast/lunch/dinner.
All subjects will receive amoxicillin (375 mg 3x per day) for 5 days. Group 2 receives a drink with placebo, maltodextrin(2,5 g 3x per day) simultaneously to the antibiotic for 5 days and after the antibiotic treatment for another 7 days. The intervention products should be consumed at breakfast/lunch/dinner.