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Effect of HEPA Air Filters on Subclinical Markers of Cardiovascular Health (WEST)

Primary Purpose

Endothelial Function, Oxidative Stress, Systemic Inflammation

Status
Completed
Phase
Not Applicable
Locations
Canada
Study Type
Interventional
Intervention
HEPA filter
Sponsored by
Simon Fraser University
About
Eligibility
Locations
Arms
Outcomes
Full info

About this trial

This is an interventional prevention trial for Endothelial Function

Eligibility Criteria

19 Years - undefined (Adult, Older Adult)All SexesAccepts Healthy Volunteers

Inclusion Criteria:

  • 19 years or older
  • Non-smoking household
  • Lives in study region (Smithers or Telkwa British Columbia)

Exclusion Criteria:

-

Sites / Locations

  • Simon Fraser University

Arms of the Study

Arm 1

Arm 2

Arm Type

Active Comparator

No Intervention

Arm Label

Indoor air HEPA filtration

Control

Arm Description

HEPA filters operating in the participant's bedroom and living room.

Control

Outcomes

Primary Outcome Measures

Reactive hyperemia index

Secondary Outcome Measures

C-reactive protein

Full Information

First Posted
December 8, 2010
Last Updated
December 1, 2016
Sponsor
Simon Fraser University
Collaborators
University of British Columbia, Health Canada, Ministry of Environment, British Columbia
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1. Study Identification

Unique Protocol Identification Number
NCT01256957
Brief Title
Effect of HEPA Air Filters on Subclinical Markers of Cardiovascular Health
Acronym
WEST
Official Title
Assessing the Impact of Wood Stove Interventions on Air Quality
Study Type
Interventional

2. Study Status

Record Verification Date
December 2010
Overall Recruitment Status
Completed
Study Start Date
November 2008 (undefined)
Primary Completion Date
April 2009 (Actual)
Study Completion Date
April 2009 (Actual)

3. Sponsor/Collaborators

Responsible Party, by Official Title
Principal Investigator
Name of the Sponsor
Simon Fraser University
Collaborators
University of British Columbia, Health Canada, Ministry of Environment, British Columbia

4. Oversight

Data Monitoring Committee
No

5. Study Description

Brief Summary
The purpose of this study is to evaluate the ability of portable high efficiency particle air (HEPA) filters to reduce exposures to PM2.5 and woodsmoke air pollution indoors and to improve subclinical indicators of microvascular function, systemic inflammation, and oxidative stress among healthy adult participants.
Detailed Description
The investigators will use portable HEPA filters in a single-blind randomized crossover design. Each participant's home will be monitored for two consecutive seven-day periods, during which time two HEPA units (one in the bedroom and one in the main living room) will be operated indoors. During one 7-day period the HEPA filters will be operated normally, and during the other period the HEPA unit will be operated without the internal filter in place (i.e., "placebo filtration"), thus blinding participants to the filters' status. The order of filtration or non-filtration will be random. At the end of each 7-day period microvascular function will be assessed, blood will be collected for assessment of systemic inflammatory markers, and urine will be collected for assessment of oxidative stress markers.

6. Conditions and Keywords

Primary Disease or Condition Being Studied in the Trial, or the Focus of the Study
Endothelial Function, Oxidative Stress, Systemic Inflammation

7. Study Design

Primary Purpose
Prevention
Study Phase
Not Applicable
Interventional Study Model
Crossover Assignment
Masking
Participant
Allocation
Randomized
Enrollment
56 (Actual)

8. Arms, Groups, and Interventions

Arm Title
Indoor air HEPA filtration
Arm Type
Active Comparator
Arm Description
HEPA filters operating in the participant's bedroom and living room.
Arm Title
Control
Arm Type
No Intervention
Arm Description
Control
Intervention Type
Device
Intervention Name(s)
HEPA filter
Other Intervention Name(s)
Honeywell model 50300, Honeywell model 18150
Primary Outcome Measure Information:
Title
Reactive hyperemia index
Time Frame
After 1 week of air filtration
Secondary Outcome Measure Information:
Title
C-reactive protein
Time Frame
After 1 week of filtration

10. Eligibility

Sex
All
Minimum Age & Unit of Time
19 Years
Accepts Healthy Volunteers
Accepts Healthy Volunteers
Eligibility Criteria
Inclusion Criteria: 19 years or older Non-smoking household Lives in study region (Smithers or Telkwa British Columbia) Exclusion Criteria: -
Overall Study Officials:
First Name & Middle Initial & Last Name & Degree
Ryan Allen, PhD
Organizational Affiliation
Simon Fraser University
Official's Role
Principal Investigator
Facility Information:
Facility Name
Simon Fraser University
City
Burnaby
State/Province
British Columbia
ZIP/Postal Code
V5A 1S6
Country
Canada

12. IPD Sharing Statement

Citations:
PubMed Identifier
21257787
Citation
Allen RW, Carlsten C, Karlen B, Leckie S, van Eeden S, Vedal S, Wong I, Brauer M. An air filter intervention study of endothelial function among healthy adults in a woodsmoke-impacted community. Am J Respir Crit Care Med. 2011 May 1;183(9):1222-30. doi: 10.1164/rccm.201010-1572OC. Epub 2011 Jan 21.
Results Reference
derived

Learn more about this trial

Effect of HEPA Air Filters on Subclinical Markers of Cardiovascular Health

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