Effect of Indian Hepatoprotective Diet in Reversibility of NAFLD (NAFLDNutrition)
Non-Alcoholic Fatty Liver Disease, Metabolic Syndrome
About this trial
This is an interventional treatment trial for Non-Alcoholic Fatty Liver Disease
Eligibility Criteria
Inclusion Criteria: Patients recently diagnosed (<3 months)diagnosed on the basis of ultrasound and /or liver transient eleastography (controlled attenuation parameter; CAP >250) Having components of metabolic syndrome like Hyperglycemia, central obesity, hypertension, hypertriglyceridemia, and low HDL cholesterol levels). Exclusion Criteria: Pregnant & lactating women Age <18 and >55 years Individuals who had been hospitalised with complications of Diabetes mellitus, Chronic Kidney disease, Hypertension in the previous 6 months Those with intake of antibiotics within last month Seriously ill and bed ridden patients Patients with viral hepatitis Patients with significant alcohol consumption (regular consumption of > 10g per day for females and > 20g/d in males), Patients having chronic inflammatory bowel disease or any chronic and autoimmune diseases will be excluded Patients with NAFLD with associated hypertriglyceridemia requiring administration of statins.
Sites / Locations
- Institute of Liver and Biliary SciencesRecruiting
Arms of the Study
Arm 1
Arm 2
Experimental
Active Comparator
Indian hepatoprotective diet (IHPD)
Western Diet
The intervention is planned as a supervised dietary supplementation, with a goal of restricting the calorie intake to 25 Kcal/Kg BW/day, with a protein intake of 1 gm/Kg BW/day i.e., around 15 % of total calories from protein, 35% from fats and 50% from carbohydrates. Major portion of the carbohydrates is vegetables, fruits and then cereals (high fiber cereals), more amount of tomato and amla at least 200 gm in a day, protein requirements are met by mainly legumes like chick pea black - (kala chana) and moong sprouts besides dals. Lean meats and egg whites would be allowed as the non-vegetarian source. Milk products used are only milk and buttermilk, curd (excluding paneer). Major source of oil would be mustard oil only.
The intervention is planned with a goal of restricting the calorie intake to 40 Kcal/Kg BW/day, around 10-15 % of total calories from protein, 30-35% from fats and 55-60% from carbohydrates. Major portion of the carbohydrates is Western fast food comprising of pizza and burger, French fries, sweets, muffins, cakes, chocolates, sugar sweetened beverages.