Effect of Intradialytic Physical ACTIvity in Addition to a NUTritional Support on Protein Energy Wasting and Physical Functioning in Chronic Hemodialysis Patients ("ACTINUT" Study) (ACTINUT)
Chronic Renal Failure, Hemodialysis Treatment, Protein-energy Wasting
About this trial
This is an interventional treatment trial for Chronic Renal Failure, Hemodialysis Treatment, Protein-energy Wasting focused on measuring Dialysis, Exercise, Protein Energy Wasting, Nutrition and Physical Fitness
Eligibility Criteria
Inclusion Criteria:
- Patients aged >18 years, treated by hemodialysis since more than 3 months
- Patients considered to be in a clinical stable state, defined as the absence of acute disease or hospitalization during the last month prior to study begin
- Patients fulfilling the diagnostic criteria of protein energy wasting according to the definition proposed by the International Society of Renal Nutrition and Metabolism (ISRNM)
- Patients having signed the informed consent for the study participation
- Patients covered by medical insurance
Exclusion Criteria:
- Medical contraindication or inability to perform physical exercise
- Inadequate dialysis (KT/V< 1.2)
- Poor hemodynamic tolerance of dialysis
- Systemic inflammation (CRP >20 mg/l)
- Pregnancy
- Major trust
Sites / Locations
- ECHO center ( confluent site )
- ECHO CENTER( St-Jacques)
Arms of the Study
Arm 1
Arm 2
No Intervention
Experimental
control group
activity group
Patients in the "control group" will receive: Dietary counseling by a dietician and if necessary modification of the prescription of oral nutritional supplements or intradialytic parenteral nutrition to reach recommended targets according to the European Best Practice Guidelines on Nutrition (energy intake 30-40 kcal/kg of ideal weight/day, protein intake 1.1 g/kg of ideal weight/day
Patients in the "group exercise" will: Dietary counseling by a dietician and if necessary modification of the prescription of oral nutritional supplements or intradialytic parenteral nutrition to reach recommended targets according to the European Best Practice Guidelines on Nutrition (energy intake 30-40 kcal/kg of ideal weight/day, protein intake 1.1 g/kg of ideal weight/day A program of physical activity consisting of progressive endurance and resistance training on a cycle ergometer, performed during the dialysis session under supervision and counseling by a qualified trainer