Effect of Locally Administered Morphine and Bupivicaine on Acute and Chronic Postmastectomy Pain
Acute Pain, Chronic Pain
About this trial
This is an interventional treatment trial for Acute Pain focused on measuring Local morphine, Postmastectomy pain
Eligibility Criteria
Inclusion Criteria:
- female patients with cancer breast scheduled for modified radical mastectomy with axillary dissection
Exclusion Criteria:
- allergy to the study drugs
- significant cardiac, respiratory, renal or hepatic disease
- drug or alcohol abuse
- psychiatric illness that would interfere with perception and assessment of pain
Sites / Locations
- Assiut University
Arms of the Study
Arm 1
Arm 2
Arm 3
Arm 4
Active Comparator
Active Comparator
Active Comparator
Placebo Comparator
local instillation of morphine 5 mg
local instillation of morphine 10 mg
local instillation of morphine 15 mg
local instillation of local anesthetics
5 ml plain bupivacaine 0.5% and 5 mg morphine .Study drugs will be diluted by saline 0.9% to 20 ml volume and irrigated onto the surgical field before skin closure and suction drain will be closed for 30 min after skin closure.
5 ml plain bupivacaine 0.5% and 10 mg morphine .Study drugs will be diluted by saline 0.9% to 20 ml volume and irrigated onto the surgical field before skin closure and suction drain will be closed for 30 min after skin closure.
5 ml plain bupivacaine 0.5% and 15 mg morphine .Study drugs will be diluted by saline 0.9% to 20 ml volume and irrigated onto the surgical field before skin closure and suction drain will be closed for 30 min after skin closure.
5 ml plain bupivacaine 0.5% .Study drugs will be diluted by saline 0.9% to 20 ml volume and irrigated onto the surgical field before skin closure and suction drain will be closed for 30 min after skin closure.