Back to resultsEffect of Neurodynamic Mobilization on Median Nerve Conduction Velocity in Carpal Tunnel Syndrome
Primary Purpose
Median Nerve Entrapment, Carpal Tunnel Syndrome
Status
Not yet recruiting
Phase
Not Applicable
Locations
Egypt
Study Type
Interventional
Intervention
conventional Treatment
Neurodynamic mobilization
Sponsored by
About this trial
This is an interventional treatment trial for Median Nerve Entrapment
Eligibility Criteria
Inclusion Criteria: Forty carpal tunnel syndrome patients. All participants referred from a physician. Their ages range from 20-50 years old. Both genders will participate in the study. Their BMI ranges between 18.5-24.9kg/m2. All participants have carpal tunnel syndrome at least in one hand. All participants suffering from mild to moderate carpal tunnel syndrome. Exclusion Criteria: Previous or current disease or trauma that might affect one or both upper limbs. Metabolic diseases that might associated with entrapment neuropathy such as diabetes mellitus, thyroid diseases, and autoimmune diseases. Pregnant women. Participants with congenital hand deformities. History of hand surgery. Sever cases of carpal tunnel syndrome that suffering from weakness of hand grip and atrophy of thenar muscle.
Sites / Locations
- Outpatient clinic faculty of physica therapy cairo university
Arms of the Study
Arm 1
Arm 2
Arm Type
Active Comparator
Experimental
Arm Label
Conventional treatment group
Neurodynamic mobilization therapy group
Arm Description
Twenty patients will receive conventional treatment in the form of superficial heat, ultrasound with freq of 1 MHz, pulsed mode 1:4 for 5 min and stretching exercise to lumbrical muscles of the hand.
Twenty patients will receive neurodynamic mobilization therapy (upper limb tension test 1) in addition to conventional treatment.
Outcomes
Primary Outcome Measures
Assessing the change in nerve conduction velocity of the median nerve.
By using Electromyography apparatus measuring nerve conduction velocity of the median nerve. (motor and sensory in m/s)
Assessing the change in wrist joint pain
By using Pressure pain threshold (PPT) is defined as the minimal amount of pressure that produces pain. A simple handheld pressure algometer (PA) with a spring is commonly used, although more sophisticated electrical devices with a strain or pneumatic pressure gauge have been developed. They hold the peak force or pressure (kp (kilopond) = 10 N, Newton = 100 kPa (kilopascal)) until tared, and some may also be connected to a computer and thus have continuous output. PPT measured with a probe 1.6 mm in diameter or larger reflects the tenderness of deep tissues as anesthesia of skin only affects the results of smaller probes.
Assessing the change in functional activity of the hand
By using Modified DASH questionnaire will be used for functional activity of the hand. The Disabilities of the Arm, Shoulder and Hand (DASH) questionnaire is a 30-item questionnaire that looks at the ability of a patient to perform certain upper extremity activities. This questionnaire is a self-report questionnaire that patients can rate difficulty and interference with daily life on a 5 point Likert scale. The QuickDASH tool uses a 5-point Likert scale from which the patient can select an appropriate number corresponding to his/her severity/function level.
Secondary Outcome Measures
Full Information
1. Study Identification
Unique Protocol Identification Number
NCT05788471
Brief Title
Effect of Neurodynamic Mobilization on Median Nerve Conduction Velocity in Carpal Tunnel Syndrome
Official Title
Effect of Neurodynamic Mobilization on Median Nerve Conduction Velocity in Carpal Tunnel Syndrome
Study Type
Interventional
2. Study Status
Record Verification Date
March 2023
Overall Recruitment Status
Not yet recruiting
Study Start Date
April 1, 2023 (Anticipated)
Primary Completion Date
June 15, 2023 (Anticipated)
Study Completion Date
August 15, 2023 (Anticipated)
3. Sponsor/Collaborators
Responsible Party, by Official Title
Principal Investigator
Name of the Sponsor
Cairo University
4. Oversight
Studies a U.S. FDA-regulated Drug Product
No
Studies a U.S. FDA-regulated Device Product
No
Data Monitoring Committee
Yes
5. Study Description
Brief Summary
The purpose of this study is to examine:
The effect of neurodynamic mobilization on the sensory and motor median nerve conduction velocity in carpal tunnel syndrome.
The effect of neurodynamic mobilization on the wrist pain in carpal tunnel syndrome.
The effect of neurodynamic mobilization on the hand function in carpal tunnel syndrome.
Detailed Description
The findings of this study will provide physiotherapists with information to know if neurodynamic mobilization techniques is effective on median nerve conduction velocity in carpal tunnel syndrome also this will improve our body of knowledge about the best modalities for treating carpal tunnel syndrome. The finding of this study may help carpal tunnel syndrome patients to avoid the exposing to complications as a result of compression of median nerve in carpal tunnel syndrome.
6. Conditions and Keywords
Primary Disease or Condition Being Studied in the Trial, or the Focus of the Study
Median Nerve Entrapment, Carpal Tunnel Syndrome
7. Study Design
Primary Purpose
Treatment
Study Phase
Not Applicable
Interventional Study Model
Parallel Assignment
Masking
ParticipantInvestigator
Allocation
Randomized
Enrollment
40 (Anticipated)
8. Arms, Groups, and Interventions
Arm Title
Conventional treatment group
Arm Type
Active Comparator
Arm Description
Twenty patients will receive conventional treatment in the form of superficial heat, ultrasound with freq of 1 MHz, pulsed mode 1:4 for 5 min and stretching exercise to lumbrical muscles of the hand.
Arm Title
Neurodynamic mobilization therapy group
Arm Type
Experimental
Arm Description
Twenty patients will receive neurodynamic mobilization therapy (upper limb tension test 1) in addition to conventional treatment.
Intervention Type
Other
Intervention Name(s)
conventional Treatment
Intervention Description
It consists of Superficial heat, Ultrasound therapy and stretching exercise to lumbrical muscles of the hand.
Intervention Type
Other
Intervention Name(s)
Neurodynamic mobilization
Intervention Description
It is the mobilisation of the nervous system as an approach to physical treatment of pain. The treatment and or assessment relies on influencing pain physiology via the mechanical treatment of neural tissues and non-neural structures surrounding the nervous system.
Primary Outcome Measure Information:
Title
Assessing the change in nerve conduction velocity of the median nerve.
Description
By using Electromyography apparatus measuring nerve conduction velocity of the median nerve. (motor and sensory in m/s)
Time Frame
at baseline and after 4 weeks of intervention
Title
Assessing the change in wrist joint pain
Description
By using Pressure pain threshold (PPT) is defined as the minimal amount of pressure that produces pain. A simple handheld pressure algometer (PA) with a spring is commonly used, although more sophisticated electrical devices with a strain or pneumatic pressure gauge have been developed. They hold the peak force or pressure (kp (kilopond) = 10 N, Newton = 100 kPa (kilopascal)) until tared, and some may also be connected to a computer and thus have continuous output. PPT measured with a probe 1.6 mm in diameter or larger reflects the tenderness of deep tissues as anesthesia of skin only affects the results of smaller probes.
Time Frame
at baseline and after 4 weeks of intervention
Title
Assessing the change in functional activity of the hand
Description
By using Modified DASH questionnaire will be used for functional activity of the hand. The Disabilities of the Arm, Shoulder and Hand (DASH) questionnaire is a 30-item questionnaire that looks at the ability of a patient to perform certain upper extremity activities. This questionnaire is a self-report questionnaire that patients can rate difficulty and interference with daily life on a 5 point Likert scale. The QuickDASH tool uses a 5-point Likert scale from which the patient can select an appropriate number corresponding to his/her severity/function level.
Time Frame
at baseline and after 4 weeks of intervention
10. Eligibility
Sex
All
Minimum Age & Unit of Time
20 Years
Maximum Age & Unit of Time
50 Years
Accepts Healthy Volunteers
Accepts Healthy Volunteers
Eligibility Criteria
Inclusion Criteria:
Forty carpal tunnel syndrome patients.
All participants referred from a physician.
Their ages range from 20-50 years old.
Both genders will participate in the study.
Their BMI ranges between 18.5-24.9kg/m2.
All participants have carpal tunnel syndrome at least in one hand.
All participants suffering from mild to moderate carpal tunnel syndrome.
Exclusion Criteria:
Previous or current disease or trauma that might affect one or both upper limbs.
Metabolic diseases that might associated with entrapment neuropathy such as diabetes mellitus, thyroid diseases, and autoimmune diseases.
Pregnant women.
Participants with congenital hand deformities.
History of hand surgery.
Sever cases of carpal tunnel syndrome that suffering from weakness of hand grip and atrophy of thenar muscle.
Central Contact Person:
First Name & Middle Initial & Last Name or Official Title & Degree
Raghda Ahmed
Phone
+201225615248
Email
rodynody88@gmail.com
Overall Study Officials:
First Name & Middle Initial & Last Name & Degree
Raghda Ahmed
Organizational Affiliation
Cairo University
Official's Role
Principal Investigator
Facility Information:
Facility Name
Outpatient clinic faculty of physica therapy cairo university
City
Dokki
Country
Egypt
12. IPD Sharing Statement
Plan to Share IPD
Undecided
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Effect of Neurodynamic Mobilization on Median Nerve Conduction Velocity in Carpal Tunnel Syndrome
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