search
Back to results

Effect of Otamixaban Versus Unfractionated Heparin + Eptifibatide in Patients With Unstable Angina/Non ST Elevation Myocardial Infarction Undergoing Early Invasive Strategy (TAO)

Primary Purpose

Acute Coronary Syndrome

Status
Completed
Phase
Phase 3
Locations
International
Study Type
Interventional
Intervention
Otamixaban
Placebo (for Otamixaban)
UFH
Placebo (for UFH)
Eptifibatide
Placebo (for Eptifibatide)
Sponsored by
Sanofi
About
Eligibility
Locations
Arms
Outcomes
Full info

About this trial

This is an interventional treatment trial for Acute Coronary Syndrome

Eligibility Criteria

18 Years - undefined (Adult, Older Adult)All SexesDoes not accept healthy volunteers

Inclusion criteria:

Patient with non-ST-segment elevation Acute Coronary Syndrome (NSTE-ACS) with:

  1. Ischemic symptoms (chest pain or equivalent) at rest ≥ 10 minutes within 24 hours of randomization,

    AND

  2. One of the two following criteria:

    • New ST-segment depression ≥ 0.1 mV (≥1 mm), or transient (< 30 minutes) ST-segment elevation ≥ 0.1 mV (≥ 1 mm) in at least 2 contiguous leads on the electrocardiogram,
    • Elevation of cardiac biomarkers within 24 hours of randomization, defined as elevated troponin T, troponin I, or CK-MB level above upper limit of normal,

    AND

  3. Planned to have a coronary angiography (followed, when indicated, by PCI) as early as possible (after at least 2 hours of treatment with study drug) and within 36 hours (at the latest on Day 3, if justified),

    AND

  4. Informed consent obtained in writing.

Exclusion criteria:

  • Revascularization procedure already performed for the qualifying event Acute ST-segment elevation MI.
  • Patient having received curative dose of anticoagulant treatment (including UFH, LMWH, or bivalirudin) for more than 24 hours prior to randomization or who have been treated by abciximab.
  • Inability to discontinue current anticoagulation in order to transition to Investigational Products according to the specified transition timing.
  • Patient who can not be treated by aspirin and clopidogrel (or any other oral antiplatelet agent) according to their local labeling.
  • Patient who cannot be treated with eptifibatide according to the national labeling (when available). In countries where eptifibatide is not approved the reference label to be considered is either the European labeling or the US labeling
  • Patient who cannot be treated with unfractionated heparin according to the national labeling.
  • Allergy to otamixaban.

The above information is not intended to contain all considerations relevant to a patient's potential participation in a clinical trial.

Sites / Locations

  • Investigational Site Number 840015
  • Investigational Site Number 840569
  • Investigational Site Number 840703
  • Investigational Site Number 840101
  • Investigational Site Number 840151
  • Investigational Site Number 840213
  • Investigational Site Number 840572
  • Investigational Site Number 840201
  • Investigational Site Number 840071
  • Investigational Site Number 840557
  • Investigational Site Number 840903
  • Investigational Site Number 840065
  • Investigational Site Number 840561
  • Investigational Site Number 840721
  • Investigational Site Number 840551
  • Investigational Site Number 840166
  • Investigational Site Number 840520
  • Investigational Site Number 840185
  • Investigational Site Number 840028
  • Investigational Site Number 840047
  • Investigational Site Number 840500
  • Investigational Site Number 840706
  • Investigational Site Number 840009
  • Investigational Site Number 840146
  • Investigational Site Number 840577
  • Investigational Site Number 840021
  • Investigational Site Number 840902
  • Investigational Site Number 840508
  • Investigational Site Number 840719
  • Investigational Site Number 840532
  • Investigational Site Number 840105
  • Investigational Site Number 840190
  • Investigational Site Number 840205
  • Investigational Site Number 840521
  • Investigational Site Number 840148
  • Investigational Site Number 840042
  • Investigational Site Number 840554
  • Investigational Site Number 840560
  • Investigational Site Number 840904
  • Investigational Site Number 840058
  • Investigational Site Number 840912
  • Investigational Site Number 840568
  • Investigational Site Number 840534
  • Investigational Site Number 840564
  • Investigational Site Number 840533
  • Investigational Site Number 840517
  • Investigational Site Number 840544
  • Investigational Site Number 840531
  • Investigational Site Number 840525
  • Investigational Site Number 840510
  • Investigational Site Number 840527
  • Investigational Site Number 840208
  • Investigational Site Number 840209
  • Investigational Site Number 840194
  • Investigational Site Number 840138
  • Investigational Site Number 840056
  • Investigational Site Number 840530
  • Investigational Site Number 840580
  • Investigational Site Number 840210
  • Investigational Site Number 840052
  • Investigational Site Number 840529
  • Investigational Site Number 840059
  • Investigational Site Number 840727
  • Investigational Site Number 840079
  • Investigational Site Number 840157
  • Investigational Site Number 840518
  • Investigational Site Number 840539
  • Investigational Site Number 840585
  • Investigational Site Number 840515
  • Investigational Site Number 840566
  • Investigational Site Number 840908
  • Investigational Site Number 840136
  • Investigational Site Number 840082
  • Investigational Site Number 840025
  • Investigational Site Number 840049
  • Investigational Site Number 840905
  • Investigational Site Number 840193
  • Investigational Site Number 840901
  • Investigational Site Number 840206
  • Investigational Site Number 840540
  • Investigational Site Number 840519
  • Investigational Site Number 840003
  • Investigational Site Number 840098
  • Investigational Site Number 840573
  • Investigational Site Number 840075
  • Investigational Site Number 840911
  • Investigational Site Number 840211
  • Investigational Site Number 840072
  • Investigational Site Number 840023
  • Investigational Site Number 840203
  • Investigational Site Number 840574
  • Investigational Site Number 840060
  • Investigational Site Number 840578
  • Investigational Site Number 840715
  • Investigational Site Number 840090
  • Investigational Site Number 840207
  • Investigational Site Number 840559
  • Investigational Site Number 840586
  • Investigational Site Number 840087
  • Investigational Site Number 840910
  • Investigational Site Number 840555
  • Investigational Site Number 840553
  • Investigational Site Number 840188
  • Investigational Site Number 840165
  • Investigational Site Number 840565
  • Investigational Site Number 840121
  • Investigational Site Number 840513
  • Investigational Site Number 032048
  • Investigational Site Number 032013
  • Investigational Site Number 032046
  • Investigational Site Number 032043
  • Investigational Site Number 032003
  • Investigational Site Number 032032
  • Investigational Site Number 032014
  • Investigational Site Number 032007
  • Investigational Site Number 032039
  • Investigational Site Number 032045
  • Investigational Site Number 032029
  • Investigational Site Number 032036
  • Investigational Site Number 032044
  • Investigational Site Number 032010
  • Investigational Site Number 032001
  • Investigational Site Number 032035
  • Investigational Site Number 032018
  • Investigational Site Number 032027
  • Investigational Site Number 032020
  • Investigational Site Number 032033
  • Investigational Site Number 032022
  • Investigational Site Number 032023
  • Investigational Site Number 032002
  • Investigational Site Number 032004
  • Investigational Site Number 032005
  • Investigational Site Number 032021
  • Investigational Site Number 032028
  • Investigational Site Number 032040
  • Investigational Site Number 032025
  • Investigational Site Number 032024
  • Investigational Site Number 032008
  • Investigational Site Number 032041
  • Investigational Site Number 032006
  • Investigational Site Number 036008
  • Investigational Site Number 036004
  • Investigational Site Number 036010
  • Investigational Site Number 036001
  • Investigational Site Number 036913
  • Investigational Site Number 036011
  • Investigational Site Number 036003
  • Investigational Site Number 040002
  • Investigational Site Number 040001
  • Investigational Site Number 112004
  • Investigational Site Number 112003
  • Investigational Site Number 112002
  • Investigational Site Number 112001
  • Investigational Site Number 056001
  • Investigational Site Number 056007
  • Investigational Site Number 056003
  • Investigational Site Number 056006
  • Investigational Site Number 056008
  • Investigational Site Number 076025
  • Investigational Site Number 076011
  • Investigational Site Number 076015
  • Investigational Site Number 076016
  • Investigational Site Number 076013
  • Investigational Site Number 076009
  • Investigational Site Number 076001
  • Investigational Site Number 076022
  • Investigational Site Number 076004
  • Investigational Site Number 076023
  • Investigational Site Number 076030
  • Investigational Site Number 076027
  • Investigational Site Number 076029
  • Investigational Site Number 076014
  • Investigational Site Number 076002
  • Investigational Site Number 076012
  • Investigational Site Number 076020
  • Investigational Site Number 076007
  • Investigational Site Number 076008
  • Investigational Site Number 076024
  • Investigational Site Number 100511
  • Investigational Site Number 100508
  • Investigational Site Number 100512
  • Investigational Site Number 100505
  • Investigational Site Number 100509
  • Investigational Site Number 100510
  • Investigational Site Number 100501
  • Investigational Site Number 100502
  • Investigational Site Number 100503
  • Investigational Site Number 100507
  • Investigational Site Number 100504
  • Investigational Site Number 100506
  • Investigational Site Number 124005
  • Investigational Site Number 124006
  • Investigational Site Number 124004
  • Investigational Site Number 124001
  • Investigational Site Number 124007
  • Investigational Site Number 124009
  • Investigational Site Number 124002
  • Investigational Site Number 152003
  • Investigational Site Number 152906
  • Investigational Site Number 152005
  • Investigational Site Number 152004
  • Investigational Site Number 152001
  • Investigational Site Number 152902
  • Investigational Site Number 152901
  • Investigational Site Number 152903
  • Investigational Site Number 152010
  • Investigational Site Number 152012
  • Investigational Site Number 152011
  • Investigational Site Number 152908
  • Investigational Site Number 152913
  • Investigational Site Number 152016
  • Investigational Site Number 152912
  • Investigational Site Number 152907
  • Investigational Site Number 152910
  • Investigational Site Number 170016
  • Investigational Site Number 170009
  • Investigational Site Number 170011
  • Investigational Site Number 170002
  • Investigational Site Number 170012
  • Investigational Site Number 170001
  • Investigational Site Number 170003
  • Investigational Site Number 170017
  • Investigational Site Number 191502
  • Investigational Site Number 191503
  • Investigational Site Number 191505
  • Investigational Site Number 191506
  • Investigational Site Number 203005
  • Investigational Site Number 203903
  • Investigational Site Number 203902
  • Investigational Site Number 203009
  • Investigational Site Number 203010
  • Investigational Site Number 203001
  • Investigational Site Number 203901
  • Investigational Site Number 203007
  • Investigational Site Number 203003
  • Investigational Site Number 203002
  • Investigational Site Number 203006
  • Investigational Site Number 818504
  • Investigational Site Number 818501
  • Investigational Site Number 818502
  • Investigational Site Number 818503
  • Investigational Site Number 233001
  • Investigational Site Number 233901
  • Investigational Site Number 250016
  • Investigational Site Number 250010
  • Investigational Site Number 250002
  • Investigational Site Number 250001
  • Investigational Site Number 250006
  • Investigational Site Number 250003
  • Investigational Site Number 250013
  • Investigational Site Number 250012
  • Investigational Site Number 250005
  • Investigational Site Number 250015
  • Investigational Site Number 250009
  • Investigational Site Number 250011
  • Investigational Site Number 250007
  • Investigational Site Number 250014
  • Investigational Site Number 250008
  • Investigational Site Number 276022
  • Investigational Site Number 276004
  • Investigational Site Number 276024
  • Investigational Site Number 276023
  • Investigational Site Number 276006
  • Investigational Site Number 276901
  • Investigational Site Number 276003
  • Investigational Site Number 276902
  • Investigational Site Number 276009
  • Investigational Site Number 276904
  • Investigational Site Number 276002
  • Investigational Site Number 276013
  • Investigational Site Number 276001
  • Investigational Site Number 276905
  • Investigational Site Number 276005
  • Investigational Site Number 276018
  • Investigational Site Number 300009
  • Investigational Site Number 300004
  • Investigational Site Number 300001
  • Investigational Site Number 300011
  • Investigational Site Number 300007
  • Investigational Site Number 300008
  • Investigational Site Number 300003
  • Investigational Site Number 300005
  • Investigational Site Number 300002
  • Investigational Site Number 300010
  • Investigational Site Number 300006
  • Investigational Site Number 344001
  • Investigational Site Number 348003
  • Investigational Site Number 348008
  • Investigational Site Number 348002
  • Investigational Site Number 348004
  • Investigational Site Number 348009
  • Investigational Site Number 348007
  • Investigational Site Number 348001
  • Investigational Site Number 348005
  • Investigational Site Number 348006
  • Investigational Site Number 356019
  • Investigational Site Number 356004
  • Investigational Site Number 356007
  • Investigational Site Number 356012
  • Investigational Site Number 356008
  • Investigational Site Number 356020
  • Investigational Site Number 356029
  • Investigational Site Number 356027
  • Investigational Site Number 356040
  • Investigational Site Number 356046
  • Investigational Site Number 356014
  • Investigational Site Number 356003
  • Investigational Site Number 356037
  • Investigational Site Number 356034
  • Investigational Site Number 356039
  • Investigational Site Number 356018
  • Investigational Site Number 356021
  • Investigational Site Number 356016
  • Investigational Site Number 356031
  • Investigational Site Number 356032
  • Investigational Site Number 356011
  • Investigational Site Number 356022
  • Investigational Site Number 356035
  • Investigational Site Number 356023
  • Investigational Site Number 356036
  • Investigational Site Number 356025
  • Investigational Site Number 356001
  • Investigational Site Number 356026
  • Investigational Site Number 356010
  • Investigational Site Number 356033
  • Investigational Site Number 356024
  • Investigational Site Number 356002
  • Investigational Site Number 356044
  • Investigational Site Number 360505
  • Investigational Site Number 360501
  • Investigational Site Number 360506
  • Investigational Site Number 360503
  • Investigational Site Number 360502
  • Investigational Site Number 376005
  • Investigational Site Number 376003
  • Investigational Site Number 376011
  • Investigational Site Number 376004
  • Investigational Site Number 376009
  • Investigational Site Number 376010
  • Investigational Site Number 376002
  • Investigational Site Number 376013
  • Investigational Site Number 376007
  • Investigational Site Number 376008
  • Investigational Site Number 376001
  • Investigational Site Number 376012
  • Investigational Site Number 380902
  • Investigational Site Number 380918
  • Investigational Site Number 380904
  • Investigational Site Number 380928
  • Investigational Site Number 380929
  • Investigational Site Number 380930
  • Investigational Site Number 380912
  • Investigational Site Number 380932
  • Investigational Site Number 380926
  • Investigational Site Number 380909
  • Investigational Site Number 380924
  • Investigational Site Number 380908
  • Investigational Site Number 380923
  • Investigational Site Number 380935
  • Investigational Site Number 380933
  • Investigational Site Number 380910
  • Investigational Site Number 380905
  • Investigational Site Number 380936
  • Investigational Site Number 380901
  • Investigational Site Number 380907
  • Investigational Site Number 380919
  • Investigational Site Number 380916
  • Investigational Site Number 380931
  • Investigational Site Number 380917
  • Investigational Site Number 380927
  • Investigational Site Number 380921
  • Investigational Site Number 380914
  • Investigational Site Number 380925
  • Investigational Site Number 400501
  • Investigational Site Number 400502
  • Investigational Site Number 410005
  • Investigational Site Number 410006
  • Investigational Site Number 410002
  • Investigational Site Number 410014
  • Investigational Site Number 410017
  • Investigational Site Number 410004
  • Investigational Site Number 410018
  • Investigational Site Number 410016
  • Investigational Site Number 410007
  • Investigational Site Number 410008
  • Investigational Site Number 410012
  • Investigational Site Number 410011
  • Investigational Site Number 410001
  • Investigational Site Number 410009
  • Investigational Site Number 410010
  • Investigational Site Number 410003
  • Investigational Site Number 410013
  • Investigational Site Number 410015
  • Investigational Site Number 428004
  • Investigational Site Number 428002
  • Investigational Site Number 428001
  • Investigational Site Number 428003
  • Investigational Site Number 422502
  • Investigational Site Number 422505
  • Investigational Site Number 440003
  • Investigational Site Number 440001
  • Investigational Site Number 440904
  • Investigational Site Number 807501
  • Investigational Site Number 458001
  • Investigational Site Number 484009
  • Investigational Site Number 484907
  • Investigational Site Number 484902
  • Investigational Site Number 484015
  • Investigational Site Number 484901
  • Investigational Site Number 484019
  • Investigational Site Number 484003
  • Investigational Site Number 484004
  • Investigational Site Number 484910
  • Investigational Site Number 484914
  • Investigational Site Number 484020
  • Investigational Site Number 484017
  • Investigational Site Number 484012
  • Investigational Site Number 484911
  • Investigational Site Number 484013
  • Investigational Site Number 499501
  • Investigational Site Number 528003
  • Investigational Site Number 528005
  • Investigational Site Number 528007
  • Investigational Site Number 528004
  • Investigational Site Number 528002
  • Investigational Site Number 554004
  • Investigational Site Number 554001
  • Investigational Site Number 554002
  • Investigational Site Number 578903
  • Investigational Site Number 578901
  • Investigational Site Number 578902
  • Investigational Site Number 591504
  • Investigational Site Number 591502
  • Investigational Site Number 604005
  • Investigational Site Number 604002
  • Investigational Site Number 604011
  • Investigational Site Number 604014
  • Investigational Site Number 604003
  • Investigational Site Number 604017
  • Investigational Site Number 604006
  • Investigational Site Number 604012
  • Investigational Site Number 604008
  • Investigational Site Number 616005
  • Investigational Site Number 616038
  • Investigational Site Number 616017
  • Investigational Site Number 616009
  • Investigational Site Number 616040
  • Investigational Site Number 616027
  • Investigational Site Number 616023
  • Investigational Site Number 616032
  • Investigational Site Number 616037
  • Investigational Site Number 616046
  • Investigational Site Number 616034
  • Investigational Site Number 616045
  • Investigational Site Number 616002
  • Investigational Site Number 616029
  • Investigational Site Number 616004
  • Investigational Site Number 616024
  • Investigational Site Number 616041
  • Investigational Site Number 616016
  • Investigational Site Number 616003
  • Investigational Site Number 616047
  • Investigational Site Number 616033
  • Investigational Site Number 616019
  • Investigational Site Number 616022
  • Investigational Site Number 616018
  • Investigational Site Number 616014
  • Investigational Site Number 616001
  • Investigational Site Number 616031
  • Investigational Site Number 616015
  • Investigational Site Number 616020
  • Investigational Site Number 620010
  • Investigational Site Number 620006
  • Investigational Site Number 620001
  • Investigational Site Number 620002
  • Investigational Site Number 620003
  • Investigational Site Number 620015
  • Investigational Site Number 620004
  • Investigational Site Number 620011
  • Investigational Site Number 642002
  • Investigational Site Number 642004
  • Investigational Site Number 642001
  • Investigational Site Number 642005
  • Investigational Site Number 642003
  • Investigational Site Number 643018
  • Investigational Site Number 643015
  • Investigational Site Number 643011
  • Investigational Site Number 643014
  • Investigational Site Number 643021
  • Investigational Site Number 643005
  • Investigational Site Number 643004
  • Investigational Site Number 643020
  • Investigational Site Number 643003
  • Investigational Site Number 643001
  • Investigational Site Number 643016
  • Investigational Site Number 643024
  • Investigational Site Number 643008
  • Investigational Site Number 643019
  • Investigational Site Number 643013
  • Investigational Site Number 643006
  • Investigational Site Number 643025
  • Investigational Site Number 643007
  • Investigational Site Number 643012
  • Investigational Site Number 643023
  • Investigational Site Number 643017
  • Investigational Site Number 688505
  • Investigational Site Number 688501
  • Investigational Site Number 688503
  • Investigational Site Number 688502
  • Investigational Site Number 688504
  • Investigational Site Number 688506
  • Investigational Site Number 702001
  • Investigational Site Number 702002
  • Investigational Site Number 703003
  • Investigational Site Number 703002
  • Investigational Site Number 703001
  • Investigational Site Number 710004
  • Investigational Site Number 710005
  • Investigational Site Number 710001
  • Investigational Site Number 710003
  • Investigational Site Number 710002
  • Investigational Site Number 710007
  • Investigational Site Number 724013
  • Investigational Site Number 724001
  • Investigational Site Number 724014
  • Investigational Site Number 724022
  • Investigational Site Number 724021
  • Investigational Site Number 724025
  • Investigational Site Number 724002
  • Investigational Site Number 724901
  • Investigational Site Number 724007
  • Investigational Site Number 724026
  • Investigational Site Number 724016
  • Investigational Site Number 724023
  • Investigational Site Number 724006
  • Investigational Site Number 724003
  • Investigational Site Number 724902
  • Investigational Site Number 724027
  • Investigational Site Number 724904
  • Investigational Site Number 724017
  • Investigational Site Number 724018
  • Investigational Site Number 724005
  • Investigational Site Number 724012
  • Investigational Site Number 724903
  • Investigational Site Number 724010
  • Investigational Site Number 724024
  • Investigational Site Number 756001
  • Investigational Site Number 756002
  • Investigational Site Number 158007
  • Investigational Site Number 158002
  • Investigational Site Number 158003
  • Investigational Site Number 158008
  • Investigational Site Number 158904
  • Investigational Site Number 158001
  • Investigational Site Number 158009
  • Investigational Site Number 764002
  • Investigational Site Number 764901
  • Investigational Site Number 764005
  • Investigational Site Number 764004
  • Investigational Site Number 764007
  • Investigational Site Number 764903
  • Investigational Site Number 764006
  • Investigational Site Number 788002
  • Investigational Site Number 788005
  • Investigational Site Number 788006
  • Investigational Site Number 788001
  • Investigational Site Number 788004
  • Investigational Site Number 792010
  • Investigational Site Number 792023
  • Investigational Site Number 792009
  • Investigational Site Number 792008
  • Investigational Site Number 792022
  • Investigational Site Number 792030
  • Investigational Site Number 792006
  • Investigational Site Number 792020
  • Investigational Site Number 792004
  • Investigational Site Number 792018
  • Investigational Site Number 792032
  • Investigational Site Number 792028
  • Investigational Site Number 792016
  • Investigational Site Number 792029
  • Investigational Site Number 792011
  • Investigational Site Number 792001
  • Investigational Site Number 792003
  • Investigational Site Number 792012
  • Investigational Site Number 792014
  • Investigational Site Number 792015
  • Investigational Site Number 792025
  • Investigational Site Number 792019
  • Investigational Site Number 792021
  • Investigational Site Number 792026
  • Investigational Site Number 804004
  • Investigational Site Number 804001
  • Investigational Site Number 804005
  • Investigational Site Number 804003
  • Investigational Site Number 826008
  • Investigational Site Number 826007
  • Investigational Site Number 826001
  • Investigational Site Number 826005
  • Investigational Site Number 826002
  • Investigational Site Number 826006
  • Investigational Site Number 826003
  • Investigational Site Number 704006
  • Investigational Site Number 704001
  • Investigational Site Number 704003
  • Investigational Site Number 704004
  • Investigational Site Number 704005

Arms of the Study

Arm 1

Arm 2

Arm 3

Arm Type

Experimental

Experimental

Active Comparator

Arm Label

Otamixaban - 0.080 mg/kg bolus + 0.100 mg/kg/h infusion

Otamixaban - 0.080 mg/kg bolus + 0.140 mg/kg/h infusion

UFH + Eptifibatide

Arm Description

From randomization until the end of the PCI or, if no PCI, up to Day 4 or hospital discharge whichever comes first: Drug A: Otamixaban (0.080 mg/kg bolus followed by 0.100 mg/kg/h infusion) Drug B: Placebo (for UFH) From PCI (downstream use) until 18-24 hour post PCI or hospital discharge whichever comes first: Drug C: Placebo (for Eptifibatide)

From randomization until the end of the PCI or, if no PCI, up to Day 4 or hospital discharge whichever comes first: Drug A: Otamixaban 0.080 mg/kg bolus followed by 0.140 mg/kg/h infusion) Drug B: Placebo (for UFH) From PCI (downstream use) until 18-24 hour post PCI or hospital discharge whichever comes first: Drug C: Placebo (for Eptifibatide)

From randomization until the end of the PCI or, if no PCI, up to Day 4 or hospital discharge whichever comes first: Drug A: Placebo (for Otamixaban) Drug B: UFH (60 IU/kg bolus followed by 12 IU/kg/h infusion) From PCI (downstream use) until 18-24 hour post PCI or hospital discharge whichever comes first: Drug C: Eptifibatide (180 mcg/kg bolus followed by 2 mcg/kg/min infusion)

Outcomes

Primary Outcome Measures

Efficacy: Adjudicated double composite of all-cause of death and new myocardial infarction
Safety: Adjudicated Thrombolysis In Myocardial Infarction (TIMI) significant bleeding (composite of TIMI major and minor)

Secondary Outcome Measures

Adjudicated Triple efficacy composite of all-cause death, new myocardial infarction and any stroke
Rehospitalization or prolongation of hospitalization due to a new episode of myocardial ischemia/myocardial infarction
Adjudicated all-cause death
Adjudicated Procedural thrombotic complications during the index PCI

Full Information

First Posted
February 25, 2010
Last Updated
April 4, 2016
Sponsor
Sanofi
search

1. Study Identification

Unique Protocol Identification Number
NCT01076764
Brief Title
Effect of Otamixaban Versus Unfractionated Heparin + Eptifibatide in Patients With Unstable Angina/Non ST Elevation Myocardial Infarction Undergoing Early Invasive Strategy
Acronym
TAO
Official Title
Randomized, Double-blind, Triple-dummy Trial to Compare the Efficacy of Otamixaban With Unfractionated Heparin + Eptifibatide, in Patients With Unstable Angina/Non ST Segment Elevation Myocardial Infarction Scheduled to Undergo an Early Invasive Strategy
Study Type
Interventional

2. Study Status

Record Verification Date
April 2016
Overall Recruitment Status
Completed
Study Start Date
April 2010 (undefined)
Primary Completion Date
May 2013 (Actual)
Study Completion Date
May 2013 (Actual)

3. Sponsor/Collaborators

Responsible Party, by Official Title
Sponsor
Name of the Sponsor
Sanofi

4. Oversight

Data Monitoring Committee
Yes

5. Study Description

Brief Summary
Primary Objective: To demonstrate the superior efficacy (composite of all-cause death + Myocardial Infarction (MI)) of Otamixaban to Unfractionated Heparin (UFH) + Eptifibatide Secondary Objectives: To demonstrate the superior efficacy (composite of all-cause death + MI + any stroke) of Otamixaban as compared to UFH + Eptifibatide To document the effect of Otamixaban on rehospitalization or prolongation of hospitalization due to a new episode of myocardial ischemia/myocardial infarction as compared to UFH + eptifibatide To document the effect on mortality (all cause death) of Otamixaban as compared to UFH + eptifibatide To document the safety of Otamixaban as compared to UFH + eptifibatide To document the effect of Otamixaban on thrombotic procedural complications during the index Percutaneous Coronary Intervention (PCI) as compared to UFH + eptifibatide
Detailed Description
Up to the interim analysis, patients are randomized to one of the Otamixaban arms or the control arm (UFH + Eptifibatide). Then after interim analysis, patients will be randomized to the continued Otamixaban arm (per Data Monitoring Committee (DMC) decision based on interim analysis results) or the control arm (UFH + Eptifibatide). Except the DMC, all participants will remain blinded to this decision until the end of study. The total duration of the study period per subject will range between 30 days and 180 days. Study end date being the Day 30 visit of the last randomized patient, follow up will be until Day 180 or study end date whichever comes first.

6. Conditions and Keywords

Primary Disease or Condition Being Studied in the Trial, or the Focus of the Study
Acute Coronary Syndrome

7. Study Design

Primary Purpose
Treatment
Study Phase
Phase 3
Interventional Study Model
Parallel Assignment
Masking
ParticipantInvestigatorOutcomes Assessor
Allocation
Randomized
Enrollment
13220 (Actual)

8. Arms, Groups, and Interventions

Arm Title
Otamixaban - 0.080 mg/kg bolus + 0.100 mg/kg/h infusion
Arm Type
Experimental
Arm Description
From randomization until the end of the PCI or, if no PCI, up to Day 4 or hospital discharge whichever comes first: Drug A: Otamixaban (0.080 mg/kg bolus followed by 0.100 mg/kg/h infusion) Drug B: Placebo (for UFH) From PCI (downstream use) until 18-24 hour post PCI or hospital discharge whichever comes first: Drug C: Placebo (for Eptifibatide)
Arm Title
Otamixaban - 0.080 mg/kg bolus + 0.140 mg/kg/h infusion
Arm Type
Experimental
Arm Description
From randomization until the end of the PCI or, if no PCI, up to Day 4 or hospital discharge whichever comes first: Drug A: Otamixaban 0.080 mg/kg bolus followed by 0.140 mg/kg/h infusion) Drug B: Placebo (for UFH) From PCI (downstream use) until 18-24 hour post PCI or hospital discharge whichever comes first: Drug C: Placebo (for Eptifibatide)
Arm Title
UFH + Eptifibatide
Arm Type
Active Comparator
Arm Description
From randomization until the end of the PCI or, if no PCI, up to Day 4 or hospital discharge whichever comes first: Drug A: Placebo (for Otamixaban) Drug B: UFH (60 IU/kg bolus followed by 12 IU/kg/h infusion) From PCI (downstream use) until 18-24 hour post PCI or hospital discharge whichever comes first: Drug C: Eptifibatide (180 mcg/kg bolus followed by 2 mcg/kg/min infusion)
Intervention Type
Drug
Intervention Name(s)
Otamixaban
Other Intervention Name(s)
XRP0673
Intervention Description
Pharmaceutical form: Intravenous (IV) solution Route of administration: IV bolus followed by continuous IV infusion
Intervention Type
Drug
Intervention Name(s)
Placebo (for Otamixaban)
Intervention Description
Pharmaceutical form: Intravenous (IV) solution Route of administration: IV bolus followed by continuous IV infusion
Intervention Type
Drug
Intervention Name(s)
UFH
Other Intervention Name(s)
Unfractionated Heparin
Intervention Description
Pharmaceutical form: Intravenous (IV) solution Route of administration: IV bolus followed by continuous IV infusion
Intervention Type
Drug
Intervention Name(s)
Placebo (for UFH)
Intervention Description
Pharmaceutical form: Intravenous (IV) solution Route of administration: IV bolus followed by continuous IV infusion
Intervention Type
Drug
Intervention Name(s)
Eptifibatide
Intervention Description
Pharmaceutical form: Intravenous (IV) solution Route of administration: IV bolus followed by continuous IV infusion
Intervention Type
Drug
Intervention Name(s)
Placebo (for Eptifibatide)
Intervention Description
Pharmaceutical form: Intravenous (IV) solution Route of administration: IV bolus followed by continuous IV infusion
Primary Outcome Measure Information:
Title
Efficacy: Adjudicated double composite of all-cause of death and new myocardial infarction
Time Frame
from randomization (day 1) to day 7
Title
Safety: Adjudicated Thrombolysis In Myocardial Infarction (TIMI) significant bleeding (composite of TIMI major and minor)
Time Frame
from day 1 to day 7
Secondary Outcome Measure Information:
Title
Adjudicated Triple efficacy composite of all-cause death, new myocardial infarction and any stroke
Time Frame
from day 1 to day 7
Title
Rehospitalization or prolongation of hospitalization due to a new episode of myocardial ischemia/myocardial infarction
Time Frame
from day 1 to day 30
Title
Adjudicated all-cause death
Time Frame
from day 1 to day 30
Title
Adjudicated Procedural thrombotic complications during the index PCI
Time Frame
during index PCI

10. Eligibility

Sex
All
Minimum Age & Unit of Time
18 Years
Accepts Healthy Volunteers
No
Eligibility Criteria
Inclusion criteria: Patient with non-ST-segment elevation Acute Coronary Syndrome (NSTE-ACS) with: Ischemic symptoms (chest pain or equivalent) at rest ≥ 10 minutes within 24 hours of randomization, AND One of the two following criteria: New ST-segment depression ≥ 0.1 mV (≥1 mm), or transient (< 30 minutes) ST-segment elevation ≥ 0.1 mV (≥ 1 mm) in at least 2 contiguous leads on the electrocardiogram, Elevation of cardiac biomarkers within 24 hours of randomization, defined as elevated troponin T, troponin I, or CK-MB level above upper limit of normal, AND Planned to have a coronary angiography (followed, when indicated, by PCI) as early as possible (after at least 2 hours of treatment with study drug) and within 36 hours (at the latest on Day 3, if justified), AND Informed consent obtained in writing. Exclusion criteria: Revascularization procedure already performed for the qualifying event Acute ST-segment elevation MI. Patient having received curative dose of anticoagulant treatment (including UFH, LMWH, or bivalirudin) for more than 24 hours prior to randomization or who have been treated by abciximab. Inability to discontinue current anticoagulation in order to transition to Investigational Products according to the specified transition timing. Patient who can not be treated by aspirin and clopidogrel (or any other oral antiplatelet agent) according to their local labeling. Patient who cannot be treated with eptifibatide according to the national labeling (when available). In countries where eptifibatide is not approved the reference label to be considered is either the European labeling or the US labeling Patient who cannot be treated with unfractionated heparin according to the national labeling. Allergy to otamixaban. The above information is not intended to contain all considerations relevant to a patient's potential participation in a clinical trial.
Overall Study Officials:
First Name & Middle Initial & Last Name & Degree
Clinical Sciences & Operations
Organizational Affiliation
Sanofi
Official's Role
Study Director
Facility Information:
Facility Name
Investigational Site Number 840015
City
Huntsville
State/Province
Alabama
ZIP/Postal Code
35801
Country
United States
Facility Name
Investigational Site Number 840569
City
Phoenix
State/Province
Arizona
ZIP/Postal Code
85008
Country
United States
Facility Name
Investigational Site Number 840703
City
Phoenix
State/Province
Arizona
ZIP/Postal Code
85054
Country
United States
Facility Name
Investigational Site Number 840101
City
Anaheim
State/Province
California
ZIP/Postal Code
92801
Country
United States
Facility Name
Investigational Site Number 840151
City
Anaheim
State/Province
California
ZIP/Postal Code
92801
Country
United States
Facility Name
Investigational Site Number 840213
City
Beverley Hills
State/Province
California
ZIP/Postal Code
90211
Country
United States
Facility Name
Investigational Site Number 840572
City
Huntington Beach
State/Province
California
ZIP/Postal Code
92648
Country
United States
Facility Name
Investigational Site Number 840201
City
Long Beach
State/Province
California
ZIP/Postal Code
90806
Country
United States
Facility Name
Investigational Site Number 840071
City
Los Angeles
State/Province
California
ZIP/Postal Code
90024
Country
United States
Facility Name
Investigational Site Number 840557
City
Los Angeles
State/Province
California
ZIP/Postal Code
90024
Country
United States
Facility Name
Investigational Site Number 840903
City
Northridge
State/Province
California
ZIP/Postal Code
91328
Country
United States
Facility Name
Investigational Site Number 840065
City
San Francisco
State/Province
California
ZIP/Postal Code
94143
Country
United States
Facility Name
Investigational Site Number 840561
City
Santa Rosa
State/Province
California
ZIP/Postal Code
95405
Country
United States
Facility Name
Investigational Site Number 840721
City
Littleton
State/Province
Colorado
ZIP/Postal Code
80120
Country
United States
Facility Name
Investigational Site Number 840551
City
Bridgeport
State/Province
Connecticut
ZIP/Postal Code
06606
Country
United States
Facility Name
Investigational Site Number 840166
City
New Haven
State/Province
Connecticut
ZIP/Postal Code
06511
Country
United States
Facility Name
Investigational Site Number 840520
City
Washington
State/Province
District of Columbia
ZIP/Postal Code
20010
Country
United States
Facility Name
Investigational Site Number 840185
City
Fort Lauderdale
State/Province
Florida
ZIP/Postal Code
33322
Country
United States
Facility Name
Investigational Site Number 840028
City
Jacksonville
State/Province
Florida
ZIP/Postal Code
32204
Country
United States
Facility Name
Investigational Site Number 840047
City
Lake Mary
State/Province
Florida
ZIP/Postal Code
32746
Country
United States
Facility Name
Investigational Site Number 840500
City
Melbourne
State/Province
Florida
ZIP/Postal Code
32901
Country
United States
Facility Name
Investigational Site Number 840706
City
Miami
State/Province
Florida
ZIP/Postal Code
33133
Country
United States
Facility Name
Investigational Site Number 840009
City
Ocala
State/Province
Florida
ZIP/Postal Code
34471
Country
United States
Facility Name
Investigational Site Number 840146
City
Ocala
State/Province
Florida
ZIP/Postal Code
34471
Country
United States
Facility Name
Investigational Site Number 840577
City
Orlando
State/Province
Florida
ZIP/Postal Code
32803
Country
United States
Facility Name
Investigational Site Number 840021
City
Sarasota
State/Province
Florida
ZIP/Postal Code
34239
Country
United States
Facility Name
Investigational Site Number 840902
City
St. Petersburg
State/Province
Florida
ZIP/Postal Code
33701
Country
United States
Facility Name
Investigational Site Number 840508
City
Tampa
State/Province
Florida
ZIP/Postal Code
33613
Country
United States
Facility Name
Investigational Site Number 840719
City
Gainesville
State/Province
Georgia
ZIP/Postal Code
30501
Country
United States
Facility Name
Investigational Site Number 840532
City
Boise
State/Province
Idaho
ZIP/Postal Code
83712
Country
United States
Facility Name
Investigational Site Number 840105
City
Aurora
State/Province
Illinois
ZIP/Postal Code
60506
Country
United States
Facility Name
Investigational Site Number 840190
City
Chicago
State/Province
Illinois
ZIP/Postal Code
60612
Country
United States
Facility Name
Investigational Site Number 840205
City
Chicago
State/Province
Illinois
ZIP/Postal Code
60637
Country
United States
Facility Name
Investigational Site Number 840521
City
Harvey
State/Province
Illinois
ZIP/Postal Code
60426
Country
United States
Facility Name
Investigational Site Number 840148
City
Joliet
State/Province
Illinois
ZIP/Postal Code
60435
Country
United States
Facility Name
Investigational Site Number 840042
City
Hammond
State/Province
Indiana
ZIP/Postal Code
46320
Country
United States
Facility Name
Investigational Site Number 840554
City
Indianapolis
State/Province
Indiana
ZIP/Postal Code
46202
Country
United States
Facility Name
Investigational Site Number 840560
City
Muncie
State/Province
Indiana
ZIP/Postal Code
47303-3400
Country
United States
Facility Name
Investigational Site Number 840904
City
Ames
State/Province
Iowa
ZIP/Postal Code
50010
Country
United States
Facility Name
Investigational Site Number 840058
City
West Des Moines
State/Province
Iowa
ZIP/Postal Code
50266
Country
United States
Facility Name
Investigational Site Number 840912
City
Overland
State/Province
Kansas
ZIP/Postal Code
66209
Country
United States
Facility Name
Investigational Site Number 840568
City
Louisville
State/Province
Kentucky
ZIP/Postal Code
40207
Country
United States
Facility Name
Investigational Site Number 840534
City
Alexandria
State/Province
Louisiana
ZIP/Postal Code
71301
Country
United States
Facility Name
Investigational Site Number 840564
City
Lake Charles
State/Province
Louisiana
ZIP/Postal Code
70601
Country
United States
Facility Name
Investigational Site Number 840533
City
New Orleans
State/Province
Louisiana
ZIP/Postal Code
70112
Country
United States
Facility Name
Investigational Site Number 840517
City
Dearborn
State/Province
Michigan
ZIP/Postal Code
48123
Country
United States
Facility Name
Investigational Site Number 840544
City
Kalamazoo
State/Province
Michigan
ZIP/Postal Code
49007
Country
United States
Facility Name
Investigational Site Number 840531
City
Saginaw
State/Province
Michigan
ZIP/Postal Code
48602
Country
United States
Facility Name
Investigational Site Number 840525
City
Minneapolis
State/Province
Minnesota
ZIP/Postal Code
55404
Country
United States
Facility Name
Investigational Site Number 840510
City
Minneapolis
State/Province
Minnesota
ZIP/Postal Code
55433
Country
United States
Facility Name
Investigational Site Number 840527
City
Tupelo
State/Province
Mississippi
ZIP/Postal Code
38801
Country
United States
Facility Name
Investigational Site Number 840208
City
Bridgeton
State/Province
Missouri
ZIP/Postal Code
63044
Country
United States
Facility Name
Investigational Site Number 840209
City
Independence
State/Province
Missouri
ZIP/Postal Code
64057
Country
United States
Facility Name
Investigational Site Number 840194
City
Kansas City
State/Province
Missouri
ZIP/Postal Code
64108
Country
United States
Facility Name
Investigational Site Number 840138
City
Kansas City
State/Province
Missouri
ZIP/Postal Code
64114
Country
United States
Facility Name
Investigational Site Number 840056
City
Kansas City
State/Province
Missouri
ZIP/Postal Code
64128
Country
United States
Facility Name
Investigational Site Number 840530
City
St Louis
State/Province
Missouri
ZIP/Postal Code
63128
Country
United States
Facility Name
Investigational Site Number 840580
City
St Louis
State/Province
Missouri
ZIP/Postal Code
63128
Country
United States
Facility Name
Investigational Site Number 840210
City
St. Louis
State/Province
Missouri
ZIP/Postal Code
63128
Country
United States
Facility Name
Investigational Site Number 840052
City
St. Louis
State/Province
Missouri
ZIP/Postal Code
63131
Country
United States
Facility Name
Investigational Site Number 840529
City
Kalispell
State/Province
Montana
ZIP/Postal Code
59901
Country
United States
Facility Name
Investigational Site Number 840059
City
Omaha
State/Province
Nebraska
ZIP/Postal Code
68122
Country
United States
Facility Name
Investigational Site Number 840727
City
Omaha
State/Province
Nebraska
ZIP/Postal Code
68122
Country
United States
Facility Name
Investigational Site Number 840079
City
Omaha
State/Province
Nebraska
ZIP/Postal Code
68131
Country
United States
Facility Name
Investigational Site Number 840157
City
Reno
State/Province
Nevada
ZIP/Postal Code
89502
Country
United States
Facility Name
Investigational Site Number 840518
City
Brooklyn
State/Province
New York
ZIP/Postal Code
11215
Country
United States
Facility Name
Investigational Site Number 840539
City
New York
State/Province
New York
ZIP/Postal Code
10021
Country
United States
Facility Name
Investigational Site Number 840585
City
Charlotte
State/Province
North Carolina
ZIP/Postal Code
28204
Country
United States
Facility Name
Investigational Site Number 840515
City
Greenville
State/Province
North Carolina
ZIP/Postal Code
27834
Country
United States
Facility Name
Investigational Site Number 840566
City
Raleigh
State/Province
North Carolina
ZIP/Postal Code
27610
Country
United States
Facility Name
Investigational Site Number 840908
City
Winston Salem
State/Province
North Carolina
ZIP/Postal Code
27157-1071
Country
United States
Facility Name
Investigational Site Number 840136
City
Minot
State/Province
North Dakota
ZIP/Postal Code
58701
Country
United States
Facility Name
Investigational Site Number 840082
City
Toledo
State/Province
Ohio
ZIP/Postal Code
43608
Country
United States
Facility Name
Investigational Site Number 840025
City
Midwest City
State/Province
Oklahoma
ZIP/Postal Code
73110
Country
United States
Facility Name
Investigational Site Number 840049
City
Oklahoma City
State/Province
Oklahoma
ZIP/Postal Code
73112
Country
United States
Facility Name
Investigational Site Number 840905
City
Oklahoma City
State/Province
Oklahoma
ZIP/Postal Code
73112
Country
United States
Facility Name
Investigational Site Number 840193
City
Oklahoma City
State/Province
Oklahoma
ZIP/Postal Code
73135
Country
United States
Facility Name
Investigational Site Number 840901
City
Tulsa
State/Province
Oklahoma
ZIP/Postal Code
74104
Country
United States
Facility Name
Investigational Site Number 840206
City
Eugene
State/Province
Oregon
ZIP/Postal Code
97401
Country
United States
Facility Name
Investigational Site Number 840540
City
Chambersburg
State/Province
Pennsylvania
ZIP/Postal Code
17201
Country
United States
Facility Name
Investigational Site Number 840519
City
Doylestown
State/Province
Pennsylvania
ZIP/Postal Code
18901
Country
United States
Facility Name
Investigational Site Number 840003
City
Erie
State/Province
Pennsylvania
ZIP/Postal Code
16502-4604
Country
United States
Facility Name
Investigational Site Number 840098
City
Harrisburg
State/Province
Pennsylvania
ZIP/Postal Code
17110
Country
United States
Facility Name
Investigational Site Number 840573
City
Philadelphia
State/Province
Pennsylvania
ZIP/Postal Code
19104
Country
United States
Facility Name
Investigational Site Number 840075
City
Pittsburgh
State/Province
Pennsylvania
ZIP/Postal Code
15224
Country
United States
Facility Name
Investigational Site Number 840911
City
Pittsburgh
State/Province
Pennsylvania
ZIP/Postal Code
15240
Country
United States
Facility Name
Investigational Site Number 840211
City
Washington
State/Province
Pennsylvania
ZIP/Postal Code
15301
Country
United States
Facility Name
Investigational Site Number 840072
City
Oak Ridge
State/Province
Tennessee
ZIP/Postal Code
37830
Country
United States
Facility Name
Investigational Site Number 840023
City
Amarillo
State/Province
Texas
ZIP/Postal Code
79106
Country
United States
Facility Name
Investigational Site Number 840203
City
Austin
State/Province
Texas
ZIP/Postal Code
78745
Country
United States
Facility Name
Investigational Site Number 840574
City
Austin
State/Province
Texas
ZIP/Postal Code
78758
Country
United States
Facility Name
Investigational Site Number 840060
City
Dallas
State/Province
Texas
ZIP/Postal Code
75216
Country
United States
Facility Name
Investigational Site Number 840578
City
Dallas
State/Province
Texas
Country
United States
Facility Name
Investigational Site Number 840715
City
Fort Worth
State/Province
Texas
ZIP/Postal Code
76104
Country
United States
Facility Name
Investigational Site Number 840090
City
Houston
State/Province
Texas
ZIP/Postal Code
77030
Country
United States
Facility Name
Investigational Site Number 840207
City
Houston
State/Province
Texas
ZIP/Postal Code
77030
Country
United States
Facility Name
Investigational Site Number 840559
City
Houston
State/Province
Texas
ZIP/Postal Code
77096
Country
United States
Facility Name
Investigational Site Number 840586
City
Houston
State/Province
Texas
ZIP/Postal Code
77096
Country
United States
Facility Name
Investigational Site Number 840087
City
Tyler
State/Province
Texas
ZIP/Postal Code
75701
Country
United States
Facility Name
Investigational Site Number 840910
City
Victoria
State/Province
Texas
ZIP/Postal Code
77901
Country
United States
Facility Name
Investigational Site Number 840555
City
Wichita Falls
State/Province
Texas
ZIP/Postal Code
76310
Country
United States
Facility Name
Investigational Site Number 840553
City
Richmond
State/Province
Virginia
ZIP/Postal Code
23249
Country
United States
Facility Name
Investigational Site Number 840188
City
Richmond
State/Province
Virginia
ZIP/Postal Code
23298
Country
United States
Facility Name
Investigational Site Number 840165
City
Salem
State/Province
Virginia
ZIP/Postal Code
24153
Country
United States
Facility Name
Investigational Site Number 840565
City
Winchester
State/Province
Virginia
ZIP/Postal Code
22601
Country
United States
Facility Name
Investigational Site Number 840121
City
Tacoma
State/Province
Washington
ZIP/Postal Code
98405
Country
United States
Facility Name
Investigational Site Number 840513
City
Manitowoc
State/Province
Wisconsin
ZIP/Postal Code
54220
Country
United States
Facility Name
Investigational Site Number 032048
City
Adrogue
ZIP/Postal Code
B1846DSK
Country
Argentina
Facility Name
Investigational Site Number 032013
City
Avellaneda
ZIP/Postal Code
1870
Country
Argentina
Facility Name
Investigational Site Number 032046
City
Buenos Aires
ZIP/Postal Code
1118
Country
Argentina
Facility Name
Investigational Site Number 032043
City
Buenos Aires
ZIP/Postal Code
C1118AAE
Country
Argentina
Facility Name
Investigational Site Number 032003
City
Buenos Aires
ZIP/Postal Code
C1181ACH
Country
Argentina
Facility Name
Investigational Site Number 032032
City
Buenos Aires
ZIP/Postal Code
C1425FSD
Country
Argentina
Facility Name
Investigational Site Number 032014
City
Caba
ZIP/Postal Code
B7400XAC
Country
Argentina
Facility Name
Investigational Site Number 032007
City
Capital Federal
ZIP/Postal Code
1181
Country
Argentina
Facility Name
Investigational Site Number 032039
City
Capital Federal
ZIP/Postal Code
C1093AAS
Country
Argentina
Facility Name
Investigational Site Number 032045
City
Capital Federal
Country
Argentina
Facility Name
Investigational Site Number 032029
City
Ciudad Autonoma De Bs.As
ZIP/Postal Code
1428
Country
Argentina
Facility Name
Investigational Site Number 032036
City
Ciudad De Buenos Aires
ZIP/Postal Code
C1426BOR
Country
Argentina
Facility Name
Investigational Site Number 032044
City
Cordoba
ZIP/Postal Code
X5004BCL
Country
Argentina
Facility Name
Investigational Site Number 032010
City
Cordoba
ZIP/Postal Code
X5119XAA
Country
Argentina
Facility Name
Investigational Site Number 032001
City
Corrientes
ZIP/Postal Code
3400
Country
Argentina
Facility Name
Investigational Site Number 032035
City
Florencio Varela
ZIP/Postal Code
B1888AAE
Country
Argentina
Facility Name
Investigational Site Number 032018
City
La Plata
ZIP/Postal Code
(B1900AXI)
Country
Argentina
Facility Name
Investigational Site Number 032027
City
La Plata
Country
Argentina
Facility Name
Investigational Site Number 032020
City
Mendoza
ZIP/Postal Code
5500
Country
Argentina
Facility Name
Investigational Site Number 032033
City
Olivos
ZIP/Postal Code
1638
Country
Argentina
Facility Name
Investigational Site Number 032022
City
Pilar
ZIP/Postal Code
1629
Country
Argentina
Facility Name
Investigational Site Number 032023
City
Resistencia
ZIP/Postal Code
3500
Country
Argentina
Facility Name
Investigational Site Number 032002
City
Resistencia
Country
Argentina
Facility Name
Investigational Site Number 032004
City
Rosario
ZIP/Postal Code
2000
Country
Argentina
Facility Name
Investigational Site Number 032005
City
Rosario
ZIP/Postal Code
2000
Country
Argentina
Facility Name
Investigational Site Number 032021
City
Rosario
ZIP/Postal Code
2000
Country
Argentina
Facility Name
Investigational Site Number 032028
City
Rosario
ZIP/Postal Code
2000
Country
Argentina
Facility Name
Investigational Site Number 032040
City
Rosario
ZIP/Postal Code
2000
Country
Argentina
Facility Name
Investigational Site Number 032025
City
San Luis
ZIP/Postal Code
5700
Country
Argentina
Facility Name
Investigational Site Number 032024
City
San Martin
ZIP/Postal Code
1650
Country
Argentina
Facility Name
Investigational Site Number 032008
City
San Miguel De Tucuman
ZIP/Postal Code
T4000NIL
Country
Argentina
Facility Name
Investigational Site Number 032041
City
Santa Fe
ZIP/Postal Code
3000
Country
Argentina
Facility Name
Investigational Site Number 032006
City
Santa Fe
ZIP/Postal Code
S3000FWO
Country
Argentina
Facility Name
Investigational Site Number 036008
City
Adelaide
ZIP/Postal Code
5000
Country
Australia
Facility Name
Investigational Site Number 036004
City
Ballarat
ZIP/Postal Code
3353
Country
Australia
Facility Name
Investigational Site Number 036010
City
Concord
ZIP/Postal Code
2137
Country
Australia
Facility Name
Investigational Site Number 036001
City
Herston
ZIP/Postal Code
4029
Country
Australia
Facility Name
Investigational Site Number 036913
City
Hobart
ZIP/Postal Code
7001
Country
Australia
Facility Name
Investigational Site Number 036011
City
Liverpool
ZIP/Postal Code
2170
Country
Australia
Facility Name
Investigational Site Number 036003
City
Prahran
ZIP/Postal Code
3004
Country
Australia
Facility Name
Investigational Site Number 040002
City
Wien
ZIP/Postal Code
1090
Country
Austria
Facility Name
Investigational Site Number 040001
City
Wien
ZIP/Postal Code
1160
Country
Austria
Facility Name
Investigational Site Number 112004
City
Gomel
ZIP/Postal Code
246012
Country
Belarus
Facility Name
Investigational Site Number 112003
City
Minsk
ZIP/Postal Code
220013
Country
Belarus
Facility Name
Investigational Site Number 112002
City
Minsk
ZIP/Postal Code
220016
Country
Belarus
Facility Name
Investigational Site Number 112001
City
Minsk
ZIP/Postal Code
220036
Country
Belarus
Facility Name
Investigational Site Number 056001
City
Bonheiden
ZIP/Postal Code
2820
Country
Belgium
Facility Name
Investigational Site Number 056007
City
Brugge
ZIP/Postal Code
8000
Country
Belgium
Facility Name
Investigational Site Number 056003
City
Brussels
ZIP/Postal Code
1020
Country
Belgium
Facility Name
Investigational Site Number 056006
City
Haine-Saint-Paul
ZIP/Postal Code
7100
Country
Belgium
Facility Name
Investigational Site Number 056008
City
Leuven
ZIP/Postal Code
3000
Country
Belgium
Facility Name
Investigational Site Number 076025
City
Campinas
ZIP/Postal Code
13015-001
Country
Brazil
Facility Name
Investigational Site Number 076011
City
Fortaleza
ZIP/Postal Code
60864190
Country
Brazil
Facility Name
Investigational Site Number 076015
City
Marilia
ZIP/Postal Code
17515-460
Country
Brazil
Facility Name
Investigational Site Number 076016
City
Maringa
ZIP/Postal Code
87015-290
Country
Brazil
Facility Name
Investigational Site Number 076013
City
Passo Fundo
ZIP/Postal Code
99010-080
Country
Brazil
Facility Name
Investigational Site Number 076009
City
Porto Alegre
ZIP/Postal Code
90035-001
Country
Brazil
Facility Name
Investigational Site Number 076001
City
Porto Alegre
ZIP/Postal Code
90610-000
Country
Brazil
Facility Name
Investigational Site Number 076022
City
Porto Alegre
ZIP/Postal Code
90620-001
Country
Brazil
Facility Name
Investigational Site Number 076004
City
Porto Alegre
ZIP/Postal Code
91350-250
Country
Brazil
Facility Name
Investigational Site Number 076023
City
Recife
ZIP/Postal Code
50100-060
Country
Brazil
Facility Name
Investigational Site Number 076030
City
Recife
ZIP/Postal Code
52051-380
Country
Brazil
Facility Name
Investigational Site Number 076027
City
Rio De Janeiro
ZIP/Postal Code
20221903
Country
Brazil
Facility Name
Investigational Site Number 076029
City
Salvador
ZIP/Postal Code
41148-900
Country
Brazil
Facility Name
Investigational Site Number 076014
City
Sao Jose Do Rio Preto
ZIP/Postal Code
15015-210
Country
Brazil
Facility Name
Investigational Site Number 076002
City
Sao Jose Do Rio Preto
ZIP/Postal Code
15090-000
Country
Brazil
Facility Name
Investigational Site Number 076012
City
Sao Paulo
ZIP/Postal Code
01323-001
Country
Brazil
Facility Name
Investigational Site Number 076020
City
Sao Paulo
ZIP/Postal Code
04012-180
Country
Brazil
Facility Name
Investigational Site Number 076007
City
Sao Paulo
ZIP/Postal Code
05403-000
Country
Brazil
Facility Name
Investigational Site Number 076008
City
Uberlandia
ZIP/Postal Code
38400-368
Country
Brazil
Facility Name
Investigational Site Number 076024
City
Votuporanga
ZIP/Postal Code
15500-003
Country
Brazil
Facility Name
Investigational Site Number 100511
City
Blagoevgrad
ZIP/Postal Code
2700
Country
Bulgaria
Facility Name
Investigational Site Number 100508
City
Kazanlak
ZIP/Postal Code
6100
Country
Bulgaria
Facility Name
Investigational Site Number 100512
City
Pazardjik
ZIP/Postal Code
4400
Country
Bulgaria
Facility Name
Investigational Site Number 100505
City
Pleven
ZIP/Postal Code
5800
Country
Bulgaria
Facility Name
Investigational Site Number 100509
City
Ruse
Country
Bulgaria
Facility Name
Investigational Site Number 100510
City
Sandanski
ZIP/Postal Code
2800
Country
Bulgaria
Facility Name
Investigational Site Number 100501
City
Sofia
ZIP/Postal Code
1202
Country
Bulgaria
Facility Name
Investigational Site Number 100502
City
Sofia
ZIP/Postal Code
1407
Country
Bulgaria
Facility Name
Investigational Site Number 100503
City
Sofia
ZIP/Postal Code
1431
Country
Bulgaria
Facility Name
Investigational Site Number 100507
City
Varna
ZIP/Postal Code
9000
Country
Bulgaria
Facility Name
Investigational Site Number 100504
City
Veliko Tarnovo
ZIP/Postal Code
5000
Country
Bulgaria
Facility Name
Investigational Site Number 100506
City
Yambol
ZIP/Postal Code
8600
Country
Bulgaria
Facility Name
Investigational Site Number 124005
City
Gatineau
ZIP/Postal Code
J8Y 1W7
Country
Canada
Facility Name
Investigational Site Number 124006
City
Hamilton
ZIP/Postal Code
L8L 2X2
Country
Canada
Facility Name
Investigational Site Number 124004
City
Montreal
ZIP/Postal Code
H2W 1T8
Country
Canada
Facility Name
Investigational Site Number 124001
City
Quebec
ZIP/Postal Code
G1V 4G5
Country
Canada
Facility Name
Investigational Site Number 124007
City
Sherbrooke
ZIP/Postal Code
J1H 5N4
Country
Canada
Facility Name
Investigational Site Number 124009
City
St. John
ZIP/Postal Code
E2L 4L2
Country
Canada
Facility Name
Investigational Site Number 124002
City
Toronto
ZIP/Postal Code
M5B 1W8
Country
Canada
Facility Name
Investigational Site Number 152003
City
Antofagasta
Country
Chile
Facility Name
Investigational Site Number 152906
City
Concepcion
ZIP/Postal Code
4070038
Country
Chile
Facility Name
Investigational Site Number 152005
City
Iquique
Country
Chile
Facility Name
Investigational Site Number 152004
City
Santiago
ZIP/Postal Code
751-0009
Country
Chile
Facility Name
Investigational Site Number 152001
City
Santiago
ZIP/Postal Code
756-0171
Country
Chile
Facility Name
Investigational Site Number 152902
City
Santiago
ZIP/Postal Code
820-7257
Country
Chile
Facility Name
Investigational Site Number 152901
City
Santiago
ZIP/Postal Code
8380456
Country
Chile
Facility Name
Investigational Site Number 152903
City
Santiago
ZIP/Postal Code
890-0085
Country
Chile
Facility Name
Investigational Site Number 152010
City
Santiago
Country
Chile
Facility Name
Investigational Site Number 152012
City
Santiago
Country
Chile
Facility Name
Investigational Site Number 152011
City
Talcahuano
ZIP/Postal Code
427-0918
Country
Chile
Facility Name
Investigational Site Number 152908
City
Temuco
Country
Chile
Facility Name
Investigational Site Number 152913
City
Temuco
Country
Chile
Facility Name
Investigational Site Number 152016
City
Valdivia
Country
Chile
Facility Name
Investigational Site Number 152912
City
Valparaíso
ZIP/Postal Code
234-0207
Country
Chile
Facility Name
Investigational Site Number 152907
City
Vina Del Mar
Country
Chile
Facility Name
Investigational Site Number 152910
City
Viña Del Mar
Country
Chile
Facility Name
Investigational Site Number 170016
City
Barranquilla
Country
Colombia
Facility Name
Investigational Site Number 170009
City
Bogota
Country
Colombia
Facility Name
Investigational Site Number 170011
City
Bogotá
Country
Colombia
Facility Name
Investigational Site Number 170002
City
Bucaramanga
Country
Colombia
Facility Name
Investigational Site Number 170012
City
Cali
Country
Colombia
Facility Name
Investigational Site Number 170001
City
Medellin
Country
Colombia
Facility Name
Investigational Site Number 170003
City
Medellin
Country
Colombia
Facility Name
Investigational Site Number 170017
City
Medellin
Country
Colombia
Facility Name
Investigational Site Number 191502
City
Slavonski Brod
ZIP/Postal Code
35000
Country
Croatia
Facility Name
Investigational Site Number 191503
City
Zagreb
ZIP/Postal Code
10000
Country
Croatia
Facility Name
Investigational Site Number 191505
City
Zagreb
ZIP/Postal Code
10000
Country
Croatia
Facility Name
Investigational Site Number 191506
City
Zagreb
ZIP/Postal Code
10000
Country
Croatia
Facility Name
Investigational Site Number 203005
City
Brno
ZIP/Postal Code
62500
Country
Czech Republic
Facility Name
Investigational Site Number 203903
City
Hradec Kralove
ZIP/Postal Code
50005
Country
Czech Republic
Facility Name
Investigational Site Number 203902
City
Liberec
ZIP/Postal Code
46063
Country
Czech Republic
Facility Name
Investigational Site Number 203009
City
Olomouc
ZIP/Postal Code
77520
Country
Czech Republic
Facility Name
Investigational Site Number 203010
City
Ostrava - Poruba
ZIP/Postal Code
70852
Country
Czech Republic
Facility Name
Investigational Site Number 203001
City
Praha 10
ZIP/Postal Code
10034
Country
Czech Republic
Facility Name
Investigational Site Number 203901
City
Praha 2
ZIP/Postal Code
12808
Country
Czech Republic
Facility Name
Investigational Site Number 203007
City
Praha 5
ZIP/Postal Code
15006
Country
Czech Republic
Facility Name
Investigational Site Number 203003
City
Praha 5
ZIP/Postal Code
15030
Country
Czech Republic
Facility Name
Investigational Site Number 203002
City
Usti Nad Labem
ZIP/Postal Code
40113
Country
Czech Republic
Facility Name
Investigational Site Number 203006
City
Zlin
ZIP/Postal Code
76275
Country
Czech Republic
Facility Name
Investigational Site Number 818504
City
Cairo
ZIP/Postal Code
11451
Country
Egypt
Facility Name
Investigational Site Number 818501
City
Cairo
ZIP/Postal Code
11566
Country
Egypt
Facility Name
Investigational Site Number 818502
City
Cairo
Country
Egypt
Facility Name
Investigational Site Number 818503
City
Giza
Country
Egypt
Facility Name
Investigational Site Number 233001
City
Tallinn
ZIP/Postal Code
10138
Country
Estonia
Facility Name
Investigational Site Number 233901
City
Tallinn
ZIP/Postal Code
13419
Country
Estonia
Facility Name
Investigational Site Number 250016
City
Avignon Cedex 2
ZIP/Postal Code
84082
Country
France
Facility Name
Investigational Site Number 250010
City
Bayonne
ZIP/Postal Code
64100
Country
France
Facility Name
Investigational Site Number 250002
City
Belfort Cedex
ZIP/Postal Code
90016
Country
France
Facility Name
Investigational Site Number 250001
City
Besancon
ZIP/Postal Code
25030
Country
France
Facility Name
Investigational Site Number 250006
City
Creteil
ZIP/Postal Code
94010
Country
France
Facility Name
Investigational Site Number 250003
City
Dijon Cedex
ZIP/Postal Code
21034
Country
France
Facility Name
Investigational Site Number 250013
City
Le Chesnay Cedex
ZIP/Postal Code
78187
Country
France
Facility Name
Investigational Site Number 250012
City
Montfermeil
ZIP/Postal Code
93370
Country
France
Facility Name
Investigational Site Number 250005
City
Mulhouse
ZIP/Postal Code
68067
Country
France
Facility Name
Investigational Site Number 250015
City
Mulhouse
ZIP/Postal Code
68070
Country
France
Facility Name
Investigational Site Number 250009
City
Paris
ZIP/Postal Code
75018
Country
France
Facility Name
Investigational Site Number 250011
City
Pau
ZIP/Postal Code
64046
Country
France
Facility Name
Investigational Site Number 250007
City
Rouen
ZIP/Postal Code
76031
Country
France
Facility Name
Investigational Site Number 250014
City
Strasbourg
ZIP/Postal Code
67091
Country
France
Facility Name
Investigational Site Number 250008
City
Toulouse Cedex 9
ZIP/Postal Code
31059
Country
France
Facility Name
Investigational Site Number 276022
City
Berlin
ZIP/Postal Code
12559
Country
Germany
Facility Name
Investigational Site Number 276004
City
Berlin
ZIP/Postal Code
13347
Country
Germany
Facility Name
Investigational Site Number 276024
City
Berlin
ZIP/Postal Code
13353
Country
Germany
Facility Name
Investigational Site Number 276023
City
Bonn
ZIP/Postal Code
53115
Country
Germany
Facility Name
Investigational Site Number 276006
City
Frankfurt Am Main
ZIP/Postal Code
65929
Country
Germany
Facility Name
Investigational Site Number 276901
City
Freiburg
ZIP/Postal Code
79106
Country
Germany
Facility Name
Investigational Site Number 276003
City
Hamburg
ZIP/Postal Code
22041
Country
Germany
Facility Name
Investigational Site Number 276902
City
Hamburg
ZIP/Postal Code
22527
Country
Germany
Facility Name
Investigational Site Number 276009
City
Heidelberg
ZIP/Postal Code
69120
Country
Germany
Facility Name
Investigational Site Number 276904
City
Heidenheim
ZIP/Postal Code
89522
Country
Germany
Facility Name
Investigational Site Number 276002
City
Kassel
ZIP/Postal Code
34121
Country
Germany
Facility Name
Investigational Site Number 276013
City
Langen
ZIP/Postal Code
63225
Country
Germany
Facility Name
Investigational Site Number 276001
City
Mainz
ZIP/Postal Code
55131
Country
Germany
Facility Name
Investigational Site Number 276905
City
Mönchengladbach
ZIP/Postal Code
41063
Country
Germany
Facility Name
Investigational Site Number 276005
City
München
ZIP/Postal Code
81377
Country
Germany
Facility Name
Investigational Site Number 276018
City
Rostock
ZIP/Postal Code
18057
Country
Germany
Facility Name
Investigational Site Number 300009
City
Alexandroupolis
ZIP/Postal Code
68100
Country
Greece
Facility Name
Investigational Site Number 300004
City
Athens
ZIP/Postal Code
10676
Country
Greece
Facility Name
Investigational Site Number 300001
City
Athens
ZIP/Postal Code
11527
Country
Greece
Facility Name
Investigational Site Number 300011
City
Athens
ZIP/Postal Code
11528
Country
Greece
Facility Name
Investigational Site Number 300007
City
Chios
ZIP/Postal Code
82100
Country
Greece
Facility Name
Investigational Site Number 300008
City
Larissa
ZIP/Postal Code
41110
Country
Greece
Facility Name
Investigational Site Number 300003
City
Melissia
ZIP/Postal Code
151 27
Country
Greece
Facility Name
Investigational Site Number 300005
City
N. Ionia
ZIP/Postal Code
14233
Country
Greece
Facility Name
Investigational Site Number 300002
City
Patras
ZIP/Postal Code
26500
Country
Greece
Facility Name
Investigational Site Number 300010
City
Thessaloniki
ZIP/Postal Code
546 36
Country
Greece
Facility Name
Investigational Site Number 300006
City
Thessaloniki
ZIP/Postal Code
57010
Country
Greece
Facility Name
Investigational Site Number 344001
City
Chai Wan
Country
Hong Kong
Facility Name
Investigational Site Number 348003
City
Budapest
ZIP/Postal Code
1027
Country
Hungary
Facility Name
Investigational Site Number 348008
City
Budapest
ZIP/Postal Code
1096
Country
Hungary
Facility Name
Investigational Site Number 348002
City
Budapest
ZIP/Postal Code
1122
Country
Hungary
Facility Name
Investigational Site Number 348004
City
Budapest
ZIP/Postal Code
1134
Country
Hungary
Facility Name
Investigational Site Number 348009
City
Szeged
ZIP/Postal Code
6720
Country
Hungary
Facility Name
Investigational Site Number 348007
City
Szekesfehervar
ZIP/Postal Code
8000
Country
Hungary
Facility Name
Investigational Site Number 348001
City
Szolnok
ZIP/Postal Code
5000
Country
Hungary
Facility Name
Investigational Site Number 348005
City
Szombathely
ZIP/Postal Code
9700
Country
Hungary
Facility Name
Investigational Site Number 348006
City
Zalaegerszeg
ZIP/Postal Code
8900
Country
Hungary
Facility Name
Investigational Site Number 356019
City
Ahmedabad
ZIP/Postal Code
380014
Country
India
Facility Name
Investigational Site Number 356004
City
Ahmedabad
ZIP/Postal Code
380054
Country
India
Facility Name
Investigational Site Number 356007
City
Ahmedabad
ZIP/Postal Code
380060
Country
India
Facility Name
Investigational Site Number 356012
City
Allahabad
ZIP/Postal Code
211003
Country
India
Facility Name
Investigational Site Number 356008
City
Bangalore
ZIP/Postal Code
560054
Country
India
Facility Name
Investigational Site Number 356020
City
Chandigarh
ZIP/Postal Code
160062
Country
India
Facility Name
Investigational Site Number 356029
City
Gurgaon
ZIP/Postal Code
122001
Country
India
Facility Name
Investigational Site Number 356027
City
Gurgaon
Country
India
Facility Name
Investigational Site Number 356040
City
Hyderabad
ZIP/Postal Code
500001
Country
India
Facility Name
Investigational Site Number 356046
City
Hyderabad
ZIP/Postal Code
500055
Country
India
Facility Name
Investigational Site Number 356014
City
Jaipur
Country
India
Facility Name
Investigational Site Number 356003
City
Karamsad
ZIP/Postal Code
388325
Country
India
Facility Name
Investigational Site Number 356037
City
Kochi
ZIP/Postal Code
682018
Country
India
Facility Name
Investigational Site Number 356034
City
Kolkata
ZIP/Postal Code
700027
Country
India
Facility Name
Investigational Site Number 356039
City
Madurai
ZIP/Postal Code
625107
Country
India
Facility Name
Investigational Site Number 356018
City
Mangalore
Country
India
Facility Name
Investigational Site Number 356021
City
Mumbai
ZIP/Postal Code
400050
Country
India
Facility Name
Investigational Site Number 356016
City
Mumbai
Country
India
Facility Name
Investigational Site Number 356031
City
Mumbai
Country
India
Facility Name
Investigational Site Number 356032
City
Mumbai
Country
India
Facility Name
Investigational Site Number 356011
City
Mysore
ZIP/Postal Code
570020
Country
India
Facility Name
Investigational Site Number 356022
City
Nagpur
ZIP/Postal Code
440012
Country
India
Facility Name
Investigational Site Number 356035
City
Nagpur
ZIP/Postal Code
440012
Country
India
Facility Name
Investigational Site Number 356023
City
Nagpur
Country
India
Facility Name
Investigational Site Number 356036
City
Nashik
ZIP/Postal Code
422005
Country
India
Facility Name
Investigational Site Number 356025
City
New Delhi
ZIP/Postal Code
110 070.
Country
India
Facility Name
Investigational Site Number 356001
City
New Delhi
ZIP/Postal Code
110060
Country
India
Facility Name
Investigational Site Number 356026
City
New Delhi
Country
India
Facility Name
Investigational Site Number 356010
City
Pune
ZIP/Postal Code
411004
Country
India
Facility Name
Investigational Site Number 356033
City
Pune
ZIP/Postal Code
411004
Country
India
Facility Name
Investigational Site Number 356024
City
Secunderabad
ZIP/Postal Code
500 003
Country
India
Facility Name
Investigational Site Number 356002
City
Varanasi
ZIP/Postal Code
221010
Country
India
Facility Name
Investigational Site Number 356044
City
Vijaywada
ZIP/Postal Code
520002
Country
India
Facility Name
Investigational Site Number 360505
City
Bandung
ZIP/Postal Code
40161
Country
Indonesia
Facility Name
Investigational Site Number 360501
City
Depok
ZIP/Postal Code
16514
Country
Indonesia
Facility Name
Investigational Site Number 360506
City
Jakarta
ZIP/Postal Code
10430
Country
Indonesia
Facility Name
Investigational Site Number 360503
City
Jakarta
ZIP/Postal Code
11420
Country
Indonesia
Facility Name
Investigational Site Number 360502
City
Jakarta
ZIP/Postal Code
12950
Country
Indonesia
Facility Name
Investigational Site Number 376005
City
Afula
ZIP/Postal Code
18101
Country
Israel
Facility Name
Investigational Site Number 376003
City
Ashkelon
ZIP/Postal Code
78278
Country
Israel
Facility Name
Investigational Site Number 376011
City
Hadera
ZIP/Postal Code
38100
Country
Israel
Facility Name
Investigational Site Number 376004
City
Haifa
ZIP/Postal Code
31048
Country
Israel
Facility Name
Investigational Site Number 376009
City
Haifa
ZIP/Postal Code
31096
Country
Israel
Facility Name
Investigational Site Number 376010
City
Holon
ZIP/Postal Code
58100
Country
Israel
Facility Name
Investigational Site Number 376002
City
Jerusalem
ZIP/Postal Code
91031
Country
Israel
Facility Name
Investigational Site Number 376013
City
Jerusalem
ZIP/Postal Code
91120
Country
Israel
Facility Name
Investigational Site Number 376007
City
Safed
ZIP/Postal Code
13100
Country
Israel
Facility Name
Investigational Site Number 376008
City
Tel Aviv
ZIP/Postal Code
64239
Country
Israel
Facility Name
Investigational Site Number 376001
City
Tel Hashomer
ZIP/Postal Code
52621
Country
Israel
Facility Name
Investigational Site Number 376012
City
Tzrifin
ZIP/Postal Code
70300
Country
Israel
Facility Name
Investigational Site Number 380902
City
Bergamo
ZIP/Postal Code
24127
Country
Italy
Facility Name
Investigational Site Number 380918
City
Bologna
ZIP/Postal Code
40138
Country
Italy
Facility Name
Investigational Site Number 380904
City
Brescia
ZIP/Postal Code
25123
Country
Italy
Facility Name
Investigational Site Number 380928
City
Brescia
ZIP/Postal Code
25124
Country
Italy
Facility Name
Investigational Site Number 380929
City
Castellanza
ZIP/Postal Code
21053
Country
Italy
Facility Name
Investigational Site Number 380930
City
Catania
ZIP/Postal Code
95123
Country
Italy
Facility Name
Investigational Site Number 380912
City
Catania
ZIP/Postal Code
95124
Country
Italy
Facility Name
Investigational Site Number 380932
City
Cittadella
ZIP/Postal Code
35013
Country
Italy
Facility Name
Investigational Site Number 380926
City
Conegliano
ZIP/Postal Code
31015
Country
Italy
Facility Name
Investigational Site Number 380909
City
Empoli
ZIP/Postal Code
50053
Country
Italy
Facility Name
Investigational Site Number 380924
City
Forlì
ZIP/Postal Code
47100
Country
Italy
Facility Name
Investigational Site Number 380908
City
Livorno
ZIP/Postal Code
57123
Country
Italy
Facility Name
Investigational Site Number 380923
City
Massa
ZIP/Postal Code
54100
Country
Italy
Facility Name
Investigational Site Number 380935
City
Massa
ZIP/Postal Code
54100
Country
Italy
Facility Name
Investigational Site Number 380933
City
Messina
ZIP/Postal Code
98100
Country
Italy
Facility Name
Investigational Site Number 380910
City
Milano
ZIP/Postal Code
20138
Country
Italy
Facility Name
Investigational Site Number 380905
City
Modena
ZIP/Postal Code
41041
Country
Italy
Facility Name
Investigational Site Number 380936
City
Napoli
ZIP/Postal Code
88100
Country
Italy
Facility Name
Investigational Site Number 380901
City
Perugia
ZIP/Postal Code
06132
Country
Italy
Facility Name
Investigational Site Number 380907
City
Pescara
ZIP/Postal Code
65100
Country
Italy
Facility Name
Investigational Site Number 380919
City
Pordenone
ZIP/Postal Code
33170
Country
Italy
Facility Name
Investigational Site Number 380916
City
Reggio Emilia
ZIP/Postal Code
42100
Country
Italy
Facility Name
Investigational Site Number 380931
City
Roma
ZIP/Postal Code
00168
Country
Italy
Facility Name
Investigational Site Number 380917
City
Roma
ZIP/Postal Code
00189
Country
Italy
Facility Name
Investigational Site Number 380927
City
Rovigo
ZIP/Postal Code
45100
Country
Italy
Facility Name
Investigational Site Number 380921
City
Rozzano
ZIP/Postal Code
20089
Country
Italy
Facility Name
Investigational Site Number 380914
City
Seriate
ZIP/Postal Code
24068
Country
Italy
Facility Name
Investigational Site Number 380925
City
Treviso
ZIP/Postal Code
31100
Country
Italy
Facility Name
Investigational Site Number 400501
City
Amman
ZIP/Postal Code
520248
Country
Jordan
Facility Name
Investigational Site Number 400502
City
Irbid
ZIP/Postal Code
360001
Country
Jordan
Facility Name
Investigational Site Number 410005
City
Busan
ZIP/Postal Code
602-715
Country
Korea, Republic of
Facility Name
Investigational Site Number 410006
City
Busan
ZIP/Postal Code
614-735
Country
Korea, Republic of
Facility Name
Investigational Site Number 410002
City
Daegu
ZIP/Postal Code
700-712
Country
Korea, Republic of
Facility Name
Investigational Site Number 410014
City
Daegu
ZIP/Postal Code
705-717
Country
Korea, Republic of
Facility Name
Investigational Site Number 410017
City
Daejeon
Country
Korea, Republic of
Facility Name
Investigational Site Number 410004
City
Goyang
ZIP/Postal Code
410-773
Country
Korea, Republic of
Facility Name
Investigational Site Number 410018
City
Guri
ZIP/Postal Code
471-020
Country
Korea, Republic of
Facility Name
Investigational Site Number 410016
City
Gwangju
ZIP/Postal Code
501-757
Country
Korea, Republic of
Facility Name
Investigational Site Number 410007
City
Seongnam
ZIP/Postal Code
463-707
Country
Korea, Republic of
Facility Name
Investigational Site Number 410008
City
Seoul
ZIP/Postal Code
110-744
Country
Korea, Republic of
Facility Name
Investigational Site Number 410012
City
Seoul
ZIP/Postal Code
120-752
Country
Korea, Republic of
Facility Name
Investigational Site Number 410011
City
Seoul
ZIP/Postal Code
130-709
Country
Korea, Republic of
Facility Name
Investigational Site Number 410001
City
Seoul
ZIP/Postal Code
134-727
Country
Korea, Republic of
Facility Name
Investigational Site Number 410009
City
Seoul
ZIP/Postal Code
137-701
Country
Korea, Republic of
Facility Name
Investigational Site Number 410010
City
Seoul
ZIP/Postal Code
138-736
Country
Korea, Republic of
Facility Name
Investigational Site Number 410003
City
Seoul
ZIP/Postal Code
152-703
Country
Korea, Republic of
Facility Name
Investigational Site Number 410013
City
Suwon
ZIP/Postal Code
443-721
Country
Korea, Republic of
Facility Name
Investigational Site Number 410015
City
Wonju
ZIP/Postal Code
220-701
Country
Korea, Republic of
Facility Name
Investigational Site Number 428004
City
Daugavpils
ZIP/Postal Code
LV-5417
Country
Latvia
Facility Name
Investigational Site Number 428002
City
Liepaja
ZIP/Postal Code
LV-3414
Country
Latvia
Facility Name
Investigational Site Number 428001
City
Riga
ZIP/Postal Code
LV-1002
Country
Latvia
Facility Name
Investigational Site Number 428003
City
Riga
ZIP/Postal Code
LV-1038
Country
Latvia
Facility Name
Investigational Site Number 422502
City
Beirut
ZIP/Postal Code
Beirut
Country
Lebanon
Facility Name
Investigational Site Number 422505
City
Beirut
Country
Lebanon
Facility Name
Investigational Site Number 440003
City
Kaunas
ZIP/Postal Code
LT-50009
Country
Lithuania
Facility Name
Investigational Site Number 440001
City
Siauliai
ZIP/Postal Code
LT-76231
Country
Lithuania
Facility Name
Investigational Site Number 440904
City
Vilnius
ZIP/Postal Code
LT-08661
Country
Lithuania
Facility Name
Investigational Site Number 807501
City
Skopje
ZIP/Postal Code
1109
Country
Macedonia, The Former Yugoslav Republic of
Facility Name
Investigational Site Number 458001
City
Kuching
ZIP/Postal Code
93586
Country
Malaysia
Facility Name
Investigational Site Number 484009
City
Aguascalientes
ZIP/Postal Code
20230
Country
Mexico
Facility Name
Investigational Site Number 484907
City
Aguascalientes
ZIP/Postal Code
20230
Country
Mexico
Facility Name
Investigational Site Number 484902
City
Guadalajara
ZIP/Postal Code
44100
Country
Mexico
Facility Name
Investigational Site Number 484015
City
Guadalajara
ZIP/Postal Code
44670
Country
Mexico
Facility Name
Investigational Site Number 484901
City
Guadalajara
ZIP/Postal Code
CP 64630
Country
Mexico
Facility Name
Investigational Site Number 484019
City
Merida
ZIP/Postal Code
97000
Country
Mexico
Facility Name
Investigational Site Number 484003
City
Mexico City
ZIP/Postal Code
14000
Country
Mexico
Facility Name
Investigational Site Number 484004
City
Monterrey
ZIP/Postal Code
64460
Country
Mexico
Facility Name
Investigational Site Number 484910
City
Morelia, Michoacan
ZIP/Postal Code
58070
Country
Mexico
Facility Name
Investigational Site Number 484914
City
México Df
ZIP/Postal Code
14080
Country
Mexico
Facility Name
Investigational Site Number 484020
City
Puebla
ZIP/Postal Code
72460
Country
Mexico
Facility Name
Investigational Site Number 484017
City
Queretaro
ZIP/Postal Code
76000
Country
Mexico
Facility Name
Investigational Site Number 484012
City
San Luis Potosi
ZIP/Postal Code
72244
Country
Mexico
Facility Name
Investigational Site Number 484911
City
San Luis Potosi
ZIP/Postal Code
78200
Country
Mexico
Facility Name
Investigational Site Number 484013
City
Xalapa
ZIP/Postal Code
91020
Country
Mexico
Facility Name
Investigational Site Number 499501
City
Podgorica
Country
Montenegro
Facility Name
Investigational Site Number 528003
City
Alkmaar
ZIP/Postal Code
1815 JD
Country
Netherlands
Facility Name
Investigational Site Number 528005
City
Arnhem
ZIP/Postal Code
6815 AD
Country
Netherlands
Facility Name
Investigational Site Number 528007
City
Leeuwarden
ZIP/Postal Code
8934 AD
Country
Netherlands
Facility Name
Investigational Site Number 528004
City
Nieuwegein
ZIP/Postal Code
3435 CM
Country
Netherlands
Facility Name
Investigational Site Number 528002
City
Rotterdam
ZIP/Postal Code
3079 DZ
Country
Netherlands
Facility Name
Investigational Site Number 554004
City
Auckland
Country
New Zealand
Facility Name
Investigational Site Number 554001
City
Hamilton
ZIP/Postal Code
3200
Country
New Zealand
Facility Name
Investigational Site Number 554002
City
Nelson
ZIP/Postal Code
7040
Country
New Zealand
Facility Name
Investigational Site Number 578903
City
Arendal
ZIP/Postal Code
4809
Country
Norway
Facility Name
Investigational Site Number 578901
City
Bergen
ZIP/Postal Code
5021
Country
Norway
Facility Name
Investigational Site Number 578902
City
Stavanger
ZIP/Postal Code
4011
Country
Norway
Facility Name
Investigational Site Number 591504
City
Panama
Country
Panama
Facility Name
Investigational Site Number 591502
City
Panamá
Country
Panama
Facility Name
Investigational Site Number 604005
City
Lambayeque
Country
Peru
Facility Name
Investigational Site Number 604002
City
Lima
ZIP/Postal Code
051
Country
Peru
Facility Name
Investigational Site Number 604011
City
Lima
ZIP/Postal Code
051
Country
Peru
Facility Name
Investigational Site Number 604014
City
Lima
ZIP/Postal Code
LIMA 01
Country
Peru
Facility Name
Investigational Site Number 604003
City
Lima
ZIP/Postal Code
LIMA 11
Country
Peru
Facility Name
Investigational Site Number 604017
City
Lima
ZIP/Postal Code
LIMA 13
Country
Peru
Facility Name
Investigational Site Number 604006
City
Lima
ZIP/Postal Code
LIMA 27
Country
Peru
Facility Name
Investigational Site Number 604012
City
Lima
ZIP/Postal Code
LIMA 31
Country
Peru
Facility Name
Investigational Site Number 604008
City
Lima
Country
Peru
Facility Name
Investigational Site Number 616005
City
Bialystok
ZIP/Postal Code
15-276
Country
Poland
Facility Name
Investigational Site Number 616038
City
Bialystok
ZIP/Postal Code
15-276
Country
Poland
Facility Name
Investigational Site Number 616017
City
Bydgoszcz
ZIP/Postal Code
85-168
Country
Poland
Facility Name
Investigational Site Number 616009
City
Bytom
ZIP/Postal Code
41-902
Country
Poland
Facility Name
Investigational Site Number 616040
City
Elblag
ZIP/Postal Code
82-300
Country
Poland
Facility Name
Investigational Site Number 616027
City
Elk
ZIP/Postal Code
19-300
Country
Poland
Facility Name
Investigational Site Number 616023
City
Gdansk
ZIP/Postal Code
80-952
Country
Poland
Facility Name
Investigational Site Number 616032
City
Jelenia Gora
ZIP/Postal Code
58-506
Country
Poland
Facility Name
Investigational Site Number 616037
City
Katowice
ZIP/Postal Code
40-635
Country
Poland
Facility Name
Investigational Site Number 616046
City
Katowice
ZIP/Postal Code
40-635
Country
Poland
Facility Name
Investigational Site Number 616034
City
Klodzko
ZIP/Postal Code
57-300
Country
Poland
Facility Name
Investigational Site Number 616045
City
Krakow
ZIP/Postal Code
31 -202
Country
Poland
Facility Name
Investigational Site Number 616002
City
Krakow
ZIP/Postal Code
31-501
Country
Poland
Facility Name
Investigational Site Number 616029
City
Lodz
ZIP/Postal Code
91-347
Country
Poland
Facility Name
Investigational Site Number 616004
City
Lomza
ZIP/Postal Code
18-400
Country
Poland
Facility Name
Investigational Site Number 616024
City
Lubin
ZIP/Postal Code
59-301
Country
Poland
Facility Name
Investigational Site Number 616041
City
Lublin
ZIP/Postal Code
20-954
Country
Poland
Facility Name
Investigational Site Number 616016
City
Ostroleka
ZIP/Postal Code
07-400
Country
Poland
Facility Name
Investigational Site Number 616003
City
Radom
ZIP/Postal Code
26-600
Country
Poland
Facility Name
Investigational Site Number 616047
City
Radom
ZIP/Postal Code
26-610
Country
Poland
Facility Name
Investigational Site Number 616033
City
Rybnik
ZIP/Postal Code
44-200
Country
Poland
Facility Name
Investigational Site Number 616019
City
Tarnów
ZIP/Postal Code
33-100
Country
Poland
Facility Name
Investigational Site Number 616022
City
Torun
ZIP/Postal Code
87-100
Country
Poland
Facility Name
Investigational Site Number 616018
City
Walbrzych
ZIP/Postal Code
58-309
Country
Poland
Facility Name
Investigational Site Number 616014
City
Warszawa
ZIP/Postal Code
02-507
Country
Poland
Facility Name
Investigational Site Number 616001
City
Warszawa
ZIP/Postal Code
04-628
Country
Poland
Facility Name
Investigational Site Number 616031
City
Wloclawek
ZIP/Postal Code
87-800
Country
Poland
Facility Name
Investigational Site Number 616015
City
Wroclaw
ZIP/Postal Code
50-420
Country
Poland
Facility Name
Investigational Site Number 616020
City
Zamosc
ZIP/Postal Code
22-400
Country
Poland
Facility Name
Investigational Site Number 620010
City
Almada
ZIP/Postal Code
2801-951
Country
Portugal
Facility Name
Investigational Site Number 620006
City
Amadora
ZIP/Postal Code
2720
Country
Portugal
Facility Name
Investigational Site Number 620001
City
Coimbra
ZIP/Postal Code
3000-075
Country
Portugal
Facility Name
Investigational Site Number 620002
City
Coimbra
ZIP/Postal Code
3041-801
Country
Portugal
Facility Name
Investigational Site Number 620003
City
Lisboa
ZIP/Postal Code
1169-024
Country
Portugal
Facility Name
Investigational Site Number 620015
City
Ponta Delgada
ZIP/Postal Code
9500-370
Country
Portugal
Facility Name
Investigational Site Number 620004
City
Setúbal
ZIP/Postal Code
2910-446
Country
Portugal
Facility Name
Investigational Site Number 620011
City
Évora
ZIP/Postal Code
7000
Country
Portugal
Facility Name
Investigational Site Number 642002
City
Brasov
ZIP/Postal Code
500059
Country
Romania
Facility Name
Investigational Site Number 642004
City
Bucuresti
ZIP/Postal Code
011461
Country
Romania
Facility Name
Investigational Site Number 642001
City
Bucuresti
ZIP/Postal Code
014461
Country
Romania
Facility Name
Investigational Site Number 642005
City
Cluj Napoca
ZIP/Postal Code
400001
Country
Romania
Facility Name
Investigational Site Number 642003
City
Targu-Mures
ZIP/Postal Code
20475
Country
Romania
Facility Name
Investigational Site Number 643018
City
Barnaul
ZIP/Postal Code
656055
Country
Russian Federation
Facility Name
Investigational Site Number 643015
City
Ekaterinburg
ZIP/Postal Code
620109
Country
Russian Federation
Facility Name
Investigational Site Number 643011
City
Kemerovo
ZIP/Postal Code
650002
Country
Russian Federation
Facility Name
Investigational Site Number 643014
City
Krasnodar
ZIP/Postal Code
350086
Country
Russian Federation
Facility Name
Investigational Site Number 643021
City
Krasnoyarsk
ZIP/Postal Code
660022
Country
Russian Federation
Facility Name
Investigational Site Number 643005
City
Moscow
ZIP/Postal Code
105229
Country
Russian Federation
Facility Name
Investigational Site Number 643004
City
Moscow
ZIP/Postal Code
111539
Country
Russian Federation
Facility Name
Investigational Site Number 643020
City
Moscow
ZIP/Postal Code
115446
Country
Russian Federation
Facility Name
Investigational Site Number 643003
City
Moscow
ZIP/Postal Code
121359
Country
Russian Federation
Facility Name
Investigational Site Number 643001
City
Moscow
ZIP/Postal Code
121552
Country
Russian Federation
Facility Name
Investigational Site Number 643016
City
Nizniy Novgorod
ZIP/Postal Code
603005
Country
Russian Federation
Facility Name
Investigational Site Number 643024
City
Novosibirsk
ZIP/Postal Code
630055
Country
Russian Federation
Facility Name
Investigational Site Number 643008
City
Saint-Peterburg
ZIP/Postal Code
196105
Country
Russian Federation
Facility Name
Investigational Site Number 643019
City
Saint-Petersburg
ZIP/Postal Code
194156
Country
Russian Federation
Facility Name
Investigational Site Number 643013
City
Samara
ZIP/Postal Code
443070
Country
Russian Federation
Facility Name
Investigational Site Number 643006
City
St-Petersburg
ZIP/Postal Code
192242
Country
Russian Federation
Facility Name
Investigational Site Number 643025
City
St-Petersburg
ZIP/Postal Code
195067
Country
Russian Federation
Facility Name
Investigational Site Number 643007
City
St-Petersburg
ZIP/Postal Code
197341
Country
Russian Federation
Facility Name
Investigational Site Number 643012
City
Tomsk
ZIP/Postal Code
634012
Country
Russian Federation
Facility Name
Investigational Site Number 643023
City
Volgograd
ZIP/Postal Code
400008
Country
Russian Federation
Facility Name
Investigational Site Number 643017
City
Yaroslavl
ZIP/Postal Code
150062
Country
Russian Federation
Facility Name
Investigational Site Number 688505
City
Belgrade
ZIP/Postal Code
11040
Country
Serbia
Facility Name
Investigational Site Number 688501
City
Kragujevac
ZIP/Postal Code
34000
Country
Serbia
Facility Name
Investigational Site Number 688503
City
Nis
ZIP/Postal Code
18000
Country
Serbia
Facility Name
Investigational Site Number 688502
City
Sremska Kamenica
ZIP/Postal Code
21204
Country
Serbia
Facility Name
Investigational Site Number 688504
City
Zemun
ZIP/Postal Code
11080
Country
Serbia
Facility Name
Investigational Site Number 688506
City
Zemun
ZIP/Postal Code
11080
Country
Serbia
Facility Name
Investigational Site Number 702001
City
Singapore
ZIP/Postal Code
168752
Country
Singapore
Facility Name
Investigational Site Number 702002
City
Singapore
ZIP/Postal Code
529889
Country
Singapore
Facility Name
Investigational Site Number 703003
City
Banska Bystrica
ZIP/Postal Code
97401
Country
Slovakia
Facility Name
Investigational Site Number 703002
City
Martin
ZIP/Postal Code
03659
Country
Slovakia
Facility Name
Investigational Site Number 703001
City
Nitra
ZIP/Postal Code
950 01
Country
Slovakia
Facility Name
Investigational Site Number 710004
City
Alberton
ZIP/Postal Code
1450
Country
South Africa
Facility Name
Investigational Site Number 710005
City
Cape Town
ZIP/Postal Code
7500
Country
South Africa
Facility Name
Investigational Site Number 710001
City
Cape Town
ZIP/Postal Code
7925
Country
South Africa
Facility Name
Investigational Site Number 710003
City
Centurion
ZIP/Postal Code
181
Country
South Africa
Facility Name
Investigational Site Number 710002
City
Kuils River
ZIP/Postal Code
7580
Country
South Africa
Facility Name
Investigational Site Number 710007
City
Pretoria
Country
South Africa
Facility Name
Investigational Site Number 724013
City
Alcorcón
ZIP/Postal Code
28992
Country
Spain
Facility Name
Investigational Site Number 724001
City
Alicante
ZIP/Postal Code
03010
Country
Spain
Facility Name
Investigational Site Number 724014
City
Badalona
ZIP/Postal Code
08916
Country
Spain
Facility Name
Investigational Site Number 724022
City
Barcelona
ZIP/Postal Code
08003
Country
Spain
Facility Name
Investigational Site Number 724021
City
Barcelona
ZIP/Postal Code
08025
Country
Spain
Facility Name
Investigational Site Number 724025
City
Barcelona
ZIP/Postal Code
08035
Country
Spain
Facility Name
Investigational Site Number 724002
City
Barcelona
ZIP/Postal Code
08036
Country
Spain
Facility Name
Investigational Site Number 724901
City
Barcelona
ZIP/Postal Code
08907
Country
Spain
Facility Name
Investigational Site Number 724007
City
Cáceres
ZIP/Postal Code
10003
Country
Spain
Facility Name
Investigational Site Number 724026
City
Elche
ZIP/Postal Code
03293
Country
Spain
Facility Name
Investigational Site Number 724016
City
Galdakao
ZIP/Postal Code
48960
Country
Spain
Facility Name
Investigational Site Number 724023
City
Girona
ZIP/Postal Code
17007
Country
Spain
Facility Name
Investigational Site Number 724006
City
La Laguna
ZIP/Postal Code
38320
Country
Spain
Facility Name
Investigational Site Number 724003
City
Madrid
ZIP/Postal Code
28035
Country
Spain
Facility Name
Investigational Site Number 724902
City
Madrid
ZIP/Postal Code
28040
Country
Spain
Facility Name
Investigational Site Number 724027
City
Madrid
ZIP/Postal Code
28041
Country
Spain
Facility Name
Investigational Site Number 724904
City
Murcia
ZIP/Postal Code
30120
Country
Spain
Facility Name
Investigational Site Number 724017
City
Málaga
ZIP/Postal Code
29010
Country
Spain
Facility Name
Investigational Site Number 724018
City
San Juan De Alicante
ZIP/Postal Code
03550
Country
Spain
Facility Name
Investigational Site Number 724005
City
Santander
ZIP/Postal Code
39008
Country
Spain
Facility Name
Investigational Site Number 724012
City
Santiago De Compostela
ZIP/Postal Code
15706
Country
Spain
Facility Name
Investigational Site Number 724903
City
Terrassa
ZIP/Postal Code
08221
Country
Spain
Facility Name
Investigational Site Number 724010
City
Torrevieja
Country
Spain
Facility Name
Investigational Site Number 724024
City
Valencia
ZIP/Postal Code
46010
Country
Spain
Facility Name
Investigational Site Number 756001
City
Lugano
ZIP/Postal Code
6900
Country
Switzerland
Facility Name
Investigational Site Number 756002
City
Zürich
ZIP/Postal Code
8091
Country
Switzerland
Facility Name
Investigational Site Number 158007
City
Kaohsiung
ZIP/Postal Code
807
Country
Taiwan
Facility Name
Investigational Site Number 158002
City
Kaohsiung
ZIP/Postal Code
833
Country
Taiwan
Facility Name
Investigational Site Number 158003
City
Linkou
Country
Taiwan
Facility Name
Investigational Site Number 158008
City
Taichung
ZIP/Postal Code
40447
Country
Taiwan
Facility Name
Investigational Site Number 158904
City
Taipei
ZIP/Postal Code
100
Country
Taiwan
Facility Name
Investigational Site Number 158001
City
Taipei
ZIP/Postal Code
104
Country
Taiwan
Facility Name
Investigational Site Number 158009
City
Taipei
ZIP/Postal Code
220
Country
Taiwan
Facility Name
Investigational Site Number 764002
City
Bangkok
ZIP/Postal Code
10330
Country
Thailand
Facility Name
Investigational Site Number 764901
City
Bangkok
ZIP/Postal Code
10400
Country
Thailand
Facility Name
Investigational Site Number 764005
City
Bangkok
ZIP/Postal Code
10700
Country
Thailand
Facility Name
Investigational Site Number 764004
City
Khon Kaen
ZIP/Postal Code
40002
Country
Thailand
Facility Name
Investigational Site Number 764007
City
Klong Luang
ZIP/Postal Code
12120
Country
Thailand
Facility Name
Investigational Site Number 764903
City
Muang
ZIP/Postal Code
50200
Country
Thailand
Facility Name
Investigational Site Number 764006
City
Rajathavee
ZIP/Postal Code
10400
Country
Thailand
Facility Name
Investigational Site Number 788002
City
Ariana
ZIP/Postal Code
2080
Country
Tunisia
Facility Name
Investigational Site Number 788005
City
Monastir
ZIP/Postal Code
5000
Country
Tunisia
Facility Name
Investigational Site Number 788006
City
Monastir
ZIP/Postal Code
5000
Country
Tunisia
Facility Name
Investigational Site Number 788001
City
Tunis
ZIP/Postal Code
1008
Country
Tunisia
Facility Name
Investigational Site Number 788004
City
Tunis
ZIP/Postal Code
1008
Country
Tunisia
Facility Name
Investigational Site Number 792010
City
Adana
ZIP/Postal Code
01339
Country
Turkey
Facility Name
Investigational Site Number 792023
City
Ankara
ZIP/Postal Code
06100
Country
Turkey
Facility Name
Investigational Site Number 792009
City
Antalya
ZIP/Postal Code
07059
Country
Turkey
Facility Name
Investigational Site Number 792008
City
Bursa
ZIP/Postal Code
16100
Country
Turkey
Facility Name
Investigational Site Number 792022
City
Bursa
ZIP/Postal Code
16509
Country
Turkey
Facility Name
Investigational Site Number 792030
City
Edirne
ZIP/Postal Code
22030
Country
Turkey
Facility Name
Investigational Site Number 792006
City
Erzurum
ZIP/Postal Code
25070
Country
Turkey
Facility Name
Investigational Site Number 792020
City
Eskisehir
ZIP/Postal Code
26480
Country
Turkey
Facility Name
Investigational Site Number 792004
City
Gaziantep
ZIP/Postal Code
27060
Country
Turkey
Facility Name
Investigational Site Number 792018
City
Istanbul
ZIP/Postal Code
34034
Country
Turkey
Facility Name
Investigational Site Number 792032
City
Istanbul
ZIP/Postal Code
34093
Country
Turkey
Facility Name
Investigational Site Number 792028
City
Istanbul
ZIP/Postal Code
34390
Country
Turkey
Facility Name
Investigational Site Number 792016
City
Istanbul
ZIP/Postal Code
34846
Country
Turkey
Facility Name
Investigational Site Number 792029
City
Istanbul
Country
Turkey
Facility Name
Investigational Site Number 792011
City
Izmir
ZIP/Postal Code
35100
Country
Turkey
Facility Name
Investigational Site Number 792001
City
Izmir
ZIP/Postal Code
35340
Country
Turkey
Facility Name
Investigational Site Number 792003
City
Izmir
ZIP/Postal Code
35360
Country
Turkey
Facility Name
Investigational Site Number 792012
City
Kayseri
ZIP/Postal Code
38039
Country
Turkey
Facility Name
Investigational Site Number 792014
City
Kocaeli
ZIP/Postal Code
41300
Country
Turkey
Facility Name
Investigational Site Number 792015
City
Konya
ZIP/Postal Code
42080
Country
Turkey
Facility Name
Investigational Site Number 792025
City
Malatya
Country
Turkey
Facility Name
Investigational Site Number 792019
City
Mersin
ZIP/Postal Code
33169
Country
Turkey
Facility Name
Investigational Site Number 792021
City
Samsun
ZIP/Postal Code
55200
Country
Turkey
Facility Name
Investigational Site Number 792026
City
Sivas
ZIP/Postal Code
58140
Country
Turkey
Facility Name
Investigational Site Number 804004
City
Cherkasy
ZIP/Postal Code
18000
Country
Ukraine
Facility Name
Investigational Site Number 804001
City
Kharkiv
ZIP/Postal Code
61018
Country
Ukraine
Facility Name
Investigational Site Number 804005
City
Lviv
ZIP/Postal Code
79015
Country
Ukraine
Facility Name
Investigational Site Number 804003
City
Zaporozhie
ZIP/Postal Code
69600
Country
Ukraine
Facility Name
Investigational Site Number 826008
City
Bournemouth
ZIP/Postal Code
BH7 7DW
Country
United Kingdom
Facility Name
Investigational Site Number 826007
City
Bradford
ZIP/Postal Code
BD9 6RJ
Country
United Kingdom
Facility Name
Investigational Site Number 826001
City
Craigavon
ZIP/Postal Code
BT63 5QQ
Country
United Kingdom
Facility Name
Investigational Site Number 826005
City
East Kilbride
ZIP/Postal Code
G75 8RG
Country
United Kingdom
Facility Name
Investigational Site Number 826002
City
Hull
ZIP/Postal Code
HU16 5JQ
Country
United Kingdom
Facility Name
Investigational Site Number 826006
City
Manchester
ZIP/Postal Code
M13 9WL
Country
United Kingdom
Facility Name
Investigational Site Number 826003
City
St Leonards
ZIP/Postal Code
TN37 7RD
Country
United Kingdom
Facility Name
Investigational Site Number 704006
City
Hanoi
Country
Vietnam
Facility Name
Investigational Site Number 704001
City
Ho Chi Minh City
Country
Vietnam
Facility Name
Investigational Site Number 704003
City
Ho Chi Minh City
Country
Vietnam
Facility Name
Investigational Site Number 704004
City
Ho Chi Minh City
Country
Vietnam
Facility Name
Investigational Site Number 704005
City
Ho Chi Minh City
Country
Vietnam

12. IPD Sharing Statement

Citations:
PubMed Identifier
23194481
Citation
Steg PG, Mehta SR, Pollack CV Jr, Bode C, Gaudin C, Fanouillere K, Moryusef A, Wiviott SD, Sabatine MS. Design and rationale of the treatment of acute coronary syndromes with otamixaban trial: a double-blind triple-dummy 2-stage randomized trial comparing otamixaban to unfractionated heparin and eptifibatide in non-ST-segment elevation acute coronary syndromes with a planned early invasive strategy. Am Heart J. 2012 Dec;164(6):817-24.e13. doi: 10.1016/j.ahj.2012.10.001. Epub 2012 Nov 7.
Results Reference
background
PubMed Identifier
23995608
Citation
Steg PG, Mehta SR, Pollack CV Jr, Bode C, Cohen M, French WJ, Hoekstra J, Rao SV, Ruzyllo W, Ruiz-Nodar JM, Sabate M, Widimsky P, Kiss RG, Navarro Estrada JL, Hod H, Kerkar P, Guneri S, Sezer M, Ruda M, Nicolau JC, Cavallini C, Ebrahim I, Petrov I, Kim JH, Jeong MH, Ramos Lopez GA, Laanmets P, Kovar F, Gaudin C, Fanouillere KC, Minini P, Hoffman EB, Moryusef A, Wiviott SD, Sabatine MS; TAO Investigators. Anticoagulation with otamixaban and ischemic events in non-ST-segment elevation acute coronary syndromes: the TAO randomized clinical trial. JAMA. 2013 Sep 18;310(11):1145-55. doi: 10.1001/jama.2013.277165.
Results Reference
result
PubMed Identifier
33518473
Citation
Abtan J, Wiviott SD, Sorbets E, Popovic B, Elbez Y, Mehta SR, Sabatine MS, Bode C, Pollack CV, Cohen M, Moccetti T, Laanmets P, Faxon D, Okreglicki A, Ducrocq G, Steg PG; TAO investigators. Prevalence, clinical determinants and prognostic implications of coronary procedural complications of percutaneous coronary intervention in non-ST-segment elevation myocardial infarction: Insights from the contemporary multinational TAO trial. Arch Cardiovasc Dis. 2021 Mar;114(3):187-196. doi: 10.1016/j.acvd.2020.09.005. Epub 2021 Jan 29.
Results Reference
derived
PubMed Identifier
33430604
Citation
Dillinger JG, Ducrocq G, Elbez Y, Cohen M, Bode C, Pollack C Jr, Petrauskiene B, Henry P, Dorobantu M, French WJ, Wiviott SD, Sabatine MS, Mehta SR, Steg PG. Sex Differences in Ischemic and Bleeding Outcomes in Patients With Non-ST-Segment-Elevation Acute Coronary Syndrome Undergoing Percutaneous Coronary Intervention: Insights From the TAO Trial. Circ Cardiovasc Interv. 2021 Jan;14(1):e009759. doi: 10.1161/CIRCINTERVENTIONS.120.009759. Epub 2021 Jan 12.
Results Reference
derived
PubMed Identifier
29895599
Citation
Dillinger JG, Ducrocq G, Elbez Y, Cohen M, Bode C, Pollack C Jr, Nicolau JC, Henry P, Kedev S, Wiviott SD, Sabatine MS, Mehta SR, Steg PG. Activated Clotting Time to Guide Heparin Dosing in Non-ST-Segment-Elevation Acute Coronary Syndrome Patients Undergoing Percutaneous Coronary Intervention and Treated With IIb/IIIa Inhibitors: Impact on Ischemic and Bleeding Outcomes: Insights From the TAO Trial. Circ Cardiovasc Interv. 2018 Jun;11(6):e006084. doi: 10.1161/CIRCINTERVENTIONS.118.006084.
Results Reference
derived

Learn more about this trial

Effect of Otamixaban Versus Unfractionated Heparin + Eptifibatide in Patients With Unstable Angina/Non ST Elevation Myocardial Infarction Undergoing Early Invasive Strategy

We'll reach out to this number within 24 hrs