Effect of Probiotics Supplementation on the Side Effects of Radiation Therapy Among Colorectal Cancer Patients
Colorectal Cancer
About this trial
This is an interventional prevention trial for Colorectal Cancer focused on measuring Colorectal cancer, Radiotherapy, immune system, Inflammatory markers, Life quality
Eligibility Criteria
Inclusion Criteria:
- Men or women,
- Aged from 35- 65 years with histologically proven CRC and
- Histologically proven CRC with stage I, II, III
- Will exposed newly to radiotherapy with the absence of any psychological, sociological or geographical condition that potentially affects the compliance with the study protocol and follow-up schedule.
Exclusion Criteria:
- Active infection treated by antibiotic therapy or recent infection or recent antibiotic use;
- Severe cardiovascular and cerebrovascular diseases that could not tolerate radical surgery;
- Recent use of probiotics, prebiotics, or synbiotic;
- Evidence of immunodeficiency;
- Cancer stage IV
- Pregnancy,
- Recent/concurrent admission to ER
- Co-existence of other malignant neoplasms, no other type of cancer in the past 5 years, any serious concomitant systemic disorders or diseases incompatible with the study.
Sites / Locations
- King Hussein Cancer Center
Arms of the Study
Arm 1
Arm 2
Experimental
Other
Probiotic Formula Capsule
Control
In this intervention arm the patients will receive oral viable capsules of probiotic contain (1*10 10 colony forming unit (CFU)/g) of lactobacillus (Lactobacillus rhamnosus , Lactobacillus acidophilus , Lactobacillus reuteri, Lactobacillus paracasei, Lactobacillus casei, Lactobacillus gasseri, Lactobacillus plantarum) and bifidobacteria (Bifidobacterium lactis, Bifidobacterium breve, Bifidobacterium bifidum, Bifidobacterium longum, Bifidobacterium infantis) species three times a per day
In this intervention arm, the control arm will receive normal treatment without any probiotic