Effect of Saturated Fat (Desi Ghee) on Gut-Liver Axis in Alcoholic Hepatitis (SFAH)
Alcoholic Hepatitis
About this trial
This is an interventional treatment trial for Alcoholic Hepatitis focused on measuring Alcoholic Hepatitis, Gut Microbiota, Dysbiosis, Malnutrition, Saturated Fat
Eligibility Criteria
Inclusion Criteria:
All patients with Severe Alcoholic Hepatitis
- Aged between 18-60 years
- Having Maddrey Score of >32
- Last Intake of alcohol from 1 day to 60days
- Patients who agree for complete alcohol abstinence from the day of enrollment
Exclusion Criteria:
Patients with-
- Maddrey Score of <32 and >100
- Comorbidities- Diabetes, Hypertension, Coronary Artery Disease, Chronic Kidney Disease, Hypothyroid
- Continuing Alcohol intake- Non-compliant patients
- Constipation
- On Laxatives until 1 month prior to study
- On probiotics until 1 month prior to study
Sites / Locations
- Institute of Liver and Biliary Sciences
Arms of the Study
Arm 1
Arm 2
Placebo Comparator
Active Comparator
Standard Treatment Group
Intervention Arm
In addition to standard pharmacological treatment, this group would receive a diet comprising of 35-40 kcal. The total distribution of the calories would be as 55-60% from carbohydrates, 20% from protein and 30% from fat, a fixed amount of 50g of oil would be given and the remaining amount of fat would be met by the invisible dietary fat. The source of visible dietary fat would be refined soyabean oil. This group would not receive any fat in the form of Desi ghee or butter or any nutritional supplement other than the prescribed diet. The diet would be explained to the patient by individual diet charts.
In addition to standard pharmacological treatment, this group would receive a diet comprising of 35-40kcal and 1.2-1.5gm protein per kg ideal body weight per day. The total distribution of the calories would be as 55-60% from carbohydrates, 20% from protein and 30-35% from fat, a fixed amount of 50g of ghee would be given in 3 divided doses of 30 ml to be taken raw, 20 ml to be used for cooking and the remaining amount of fat would be met by the invisible dietary fat. The source of visible fat would be exclusively Desi ghee. This group would not receive any fat in the form of butter or any other oil or any other nutritional supplement other than the prescribed diet. The diet would be explained to the patient by individual diet charts.