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Effect of Serelaxin Versus Standard of Care in Acute Heart Failure (AHF) Patients (RELAX-AHF-EU)

Primary Purpose

Acute Heart Failure (AHF)

Status

Terminated

Phase

Phase 3

Locations

International

Study Type

Interventional

Intervention

Serelaxin

Standard of Care

About this trial

This is an interventional treatment trial for Acute Heart Failure (AHF) focused on measuring AHF,, RLX030,, SOC,, WHF,, RELAX-AHF-EU, Renal Impairment

Eligibility Criteria

18 Years - undefined (Adult, Older Adult)All SexesDoes not accept healthy volunteers

Inclusion Criteria:

Systolic blood pressure ≥ 125 mmHg
Admitted for Acute Heart Failure (AHF)
Received intravenous furosemide (or equivalent) at any time between presentation and the start of screening
eGFR on admission: ≥ 25 and ≤75 mL/min/1.73 m^2

Exclusion Criteria:

Dyspnea (non-cardiac causes)
T > 38.5°C
Clinical evidence of acute coronary syndrome currently or within 30 days prior to enrollment.
Significant left ventricular outflow obstruction, uncorrected, such as obstructive hypertrophic cardiomyopathy or severe aortic stenosis (i.e., aortic valve area <1.0 cm^2 or mean gradient >50 mmHg on prior or current echocardiogram), severe aortic regurgitation and severe mitral stenosis.
AHF due to significant arrhythmias
Acute myocarditis or hypertrophic obstructive, restrictive, or constrictive cardiomyopathy (does not include restrictive mitral filling patterns seen on Doppler echocardiographic assessments of diastolic function).

Arms of the Study

Arm 1

Arm 2

Arm Type

Experimental

Other

Arm Label

Serelaxin + Standard of Care

Standard of Care (SOC)

Arm Description

Serelaxin (30 µg/kg/day) as continuous 48 hour intravenous infusion plus standard of care.

All patients were required to receive standard of care background heart failure (HF) management during the study, according to local guidelines/international standards. This treatment can include but is not limited to intravenous and/or oral diuretics, angiotensin-converting enzyme (ACE) inhibitors/angiotensin receptor antagonists, beta blockers and aldosterone receptor antagonists, etc.

Outcomes

Primary Outcome Measures

Percentage of Participants With Worsening Heart Failure (WHF) / All Cause of Deaths Through Day 5

In-hospital WHF through Day 5 post-randomization included worsening signs and/or symptoms of heart failure that required an intensification of intravenous therapy for heart failure or mechanical ventilation, renal or circulatory support. A central event adjudication committee was appointed to oversee the WHF primary endpoint adjudication.

Secondary Outcome Measures

Percentage of Participants With In-hospital Worsening Heart Failure/All-Cause Death/Readmission for Heart Failure Through Day 14

WHF/death/readmission for heart failure through Day 14. WHF/deaths through Day 5 were adjudicated and confirmed by the Clinical Endpoint Committee, WHF/deaths after Day 5 through Day 14 and readmission through Day 14 were as reported by the investigators.

Percentage of Participants With Persistent Sign or Symptoms of Heart Failure / Non-Improvement at Any Post Baseline Visit Through Day 5

Persistent or non-improvement in any signs or symptoms of HF at any post baseline visit up to Day 5.

Percentage of Participants With Renal Deterioration at Any Post Baseline Visit Through Day 14

Renal deterioration is defined as > or = 0.3 mg/dL increase from screening in serum creatinine.

Length of Index Hospital Stay

Length of stay (in hours) is defined as the index hospitalization discharge date and time minus the index hospitalization start date and time.

Percentage of Participants With Adverse Events as Assessment of Safety and Tolerability of Serelaxin in AHF Patients

Change From Baseline in Health-related Quality of Life Index Value, Assessed by EuroQoL EQ-5D-5L Questionnaire.

EQ-5D-5L is a questionnaire designed to assess health status in adults consisting of 5 dimensions (mobility, self-care, usual activities, pain/discomfort, anxiety/depression). The results were converted into a single index value using UK as the reference country for all countries. Range -0.3 (worst possible state) to 1 (best possible state).

Full Information

NCT ID

NCT02064868

First Posted

February 14, 2014

Last Updated

December 18, 2018

Sponsor

Novartis Pharmaceuticals

1. Study Identification

Unique Protocol Identification Number

NCT02064868

Brief Title

Effect of Serelaxin Versus Standard of Care in Acute Heart Failure (AHF) Patients

Acronym

RELAX-AHF-EU

Official Title

A Multicenter, Prospective, Randomized, Open-label Study to Assess the Effect of Serelaxin Versus Standard of Care in Acute Heart Failure (AHF) Patients

Study Type

Interventional

2. Study Status

Record Verification Date

December 2018

Overall Recruitment Status

Terminated

Why Stopped

Study was terminated based on results from pivotal adult AHF study CRLX030A2301

Study Start Date

January 31, 2014 (Actual)

Primary Completion Date

March 26, 2017 (Actual)

Study Completion Date

April 25, 2017 (Actual)

3. Sponsor/Collaborators

Responsible Party, by Official Title

Sponsor

Name of the Sponsor

Novartis Pharmaceuticals

4. Oversight

Data Monitoring Committee

Yes

5. Study Description

Brief Summary

This was a multinational, multicenter, randomized, open-label study to confirm and expand the efficacy, safety and tolerability evidence of 48 hours intravenous infusion of serelaxin (30 micrograms/kg/day) when added to Standard of Care (SoC) in patients admitted to hospital for Acute Heart Failure (AHF).

Detailed Description

This study was aimed at generating clinical evidence, especially on the short term period (in-hospital and at 30 days) to complement existing and future serelaxin data sets in Acute Heart Failure (AHF).

6. Conditions and Keywords

Primary Disease or Condition Being Studied in the Trial, or the Focus of the Study

Acute Heart Failure (AHF)

Keywords

AHF,, RLX030,, SOC,, WHF,, RELAX-AHF-EU, Renal Impairment

7. Study Design

Primary Purpose

Treatment

Study Phase

Phase 3

Interventional Study Model

Parallel Assignment

Masking

None (Open Label)

Allocation

Randomized

Enrollment

2666 (Actual)

8. Arms, Groups, and Interventions

Arm Title

Serelaxin + Standard of Care

Arm Type

Experimental

Arm Description

Serelaxin (30 µg/kg/day) as continuous 48 hour intravenous infusion plus standard of care.

Arm Title

Standard of Care (SOC)

Arm Type

Other

Arm Description

Intervention Type

Drug

Intervention Name(s)

Serelaxin

Other Intervention Name(s)

RLX030

Intervention Description

30 µg/kg/day IV infusion

Intervention Type

Drug

Intervention Name(s)

Standard of Care

Intervention Description

This treatment can include but is not limited to intravenous and/or oral diuretics, angiotensin-converting enzyme (ACE) inhibitors/angiotensin receptor antagonists, beta blockers and aldosterone receptor antagonists, etc.

Primary Outcome Measure Information:

Title

Percentage of Participants With Worsening Heart Failure (WHF) / All Cause of Deaths Through Day 5

Description

Time Frame

5 days

Secondary Outcome Measure Information:

Title

Percentage of Participants With In-hospital Worsening Heart Failure/All-Cause Death/Readmission for Heart Failure Through Day 14

Description

Time Frame

14 days

Title

Percentage of Participants With Persistent Sign or Symptoms of Heart Failure / Non-Improvement at Any Post Baseline Visit Through Day 5

Description

Persistent or non-improvement in any signs or symptoms of HF at any post baseline visit up to Day 5.

Time Frame

5 days

Title

Percentage of Participants With Renal Deterioration at Any Post Baseline Visit Through Day 14

Description

Renal deterioration is defined as > or = 0.3 mg/dL increase from screening in serum creatinine.

Time Frame

14 days

Title

Length of Index Hospital Stay

Description

Length of stay (in hours) is defined as the index hospitalization discharge date and time minus the index hospitalization start date and time.

Time Frame

30 Days

Title

Percentage of Participants With Adverse Events as Assessment of Safety and Tolerability of Serelaxin in AHF Patients

Time Frame

Adverse Events (AE): 5 Days / Serious Adverse Events (SAE): 14 days / All cause deaths 30 days

Title

Change From Baseline in Health-related Quality of Life Index Value, Assessed by EuroQoL EQ-5D-5L Questionnaire.

Description

Time Frame

Baseline, Day 5, Day 14

10. Eligibility

Sex

All

Minimum Age & Unit of Time

18 Years

Accepts Healthy Volunteers

Eligibility Criteria

Inclusion Criteria: Systolic blood pressure ≥ 125 mmHg Admitted for Acute Heart Failure (AHF) Received intravenous furosemide (or equivalent) at any time between presentation and the start of screening eGFR on admission: ≥ 25 and ≤75 mL/min/1.73 m^2 Exclusion Criteria: Dyspnea (non-cardiac causes) T > 38.5°C Clinical evidence of acute coronary syndrome currently or within 30 days prior to enrollment. Significant left ventricular outflow obstruction, uncorrected, such as obstructive hypertrophic cardiomyopathy or severe aortic stenosis (i.e., aortic valve area <1.0 cm^2 or mean gradient >50 mmHg on prior or current echocardiogram), severe aortic regurgitation and severe mitral stenosis. AHF due to significant arrhythmias Acute myocarditis or hypertrophic obstructive, restrictive, or constrictive cardiomyopathy (does not include restrictive mitral filling patterns seen on Doppler echocardiographic assessments of diastolic function).

Overall Study Officials:

First Name & Middle Initial & Last Name & Degree

Novartis Pharmaceuticals

Organizational Affiliation

Novartis Pharmaceuticals

Official's Role

Study Director

Facility Information:

Facility Name

Novartis Investigative Site

City

Feldkirch

ZIP/Postal Code

A-6807

Country

Austria

Facility Name

Novartis Investigative Site

City

Graz

ZIP/Postal Code

8020

Country

Austria

Facility Name

Novartis Investigative Site

City

Linz

ZIP/Postal Code

A-4020

Country

Austria

Facility Name

Novartis Investigative Site

City

Salzburg

ZIP/Postal Code

5010

Country

Austria

Facility Name

Novartis Investigative Site

City

Salzburg

ZIP/Postal Code

A-5020

Country

Austria

Facility Name

Novartis Investigative Site

City

St. Poelten

ZIP/Postal Code

3100

Country

Austria

Facility Name

Novartis Investigative Site

City

Vienna

ZIP/Postal Code

1130

Country

Austria

Facility Name

Novartis Investigative Site

City

Vienna

ZIP/Postal Code

A-1020

Country

Austria

Facility Name

Novartis Investigative Site

City

Wien

ZIP/Postal Code

A-1160

Country

Austria

Facility Name

Novartis Investigative Site

City

Aalst

ZIP/Postal Code

9300

Country

Belgium

Facility Name

Novartis Investigative Site

City

Brugge

ZIP/Postal Code

8000

Country

Belgium

Facility Name

Novartis Investigative Site

City

Brussel

ZIP/Postal Code

1090

Country

Belgium

Facility Name

Novartis Investigative Site

City

Gent

ZIP/Postal Code

9000

Country

Belgium

Facility Name

Novartis Investigative Site

City

Hasselt

ZIP/Postal Code

3500

Country

Belgium

Facility Name

Novartis Investigative Site

City

Leuven

ZIP/Postal Code

3000

Country

Belgium

Facility Name

Novartis Investigative Site

City

Liege

ZIP/Postal Code

4000

Country

Belgium

Facility Name

Novartis Investigative Site

City

Lodelinsart

ZIP/Postal Code

6042

Country

Belgium

Facility Name

Novartis Investigative Site

City

Mol

ZIP/Postal Code

2400

Country

Belgium

Facility Name

Novartis Investigative Site

City

Mons

ZIP/Postal Code

7000

Country

Belgium

Facility Name

Novartis Investigative Site

City

Roeselare

ZIP/Postal Code

8800

Country

Belgium

Facility Name

Novartis Investigative Site

City

Ronse

ZIP/Postal Code

9600

Country

Belgium

Facility Name

Novartis Investigative Site

City

Turnhout

ZIP/Postal Code

2300

Country

Belgium

Facility Name

Novartis Investigative Site

City

Gabrovo

ZIP/Postal Code

5300

Country

Bulgaria

Facility Name

Novartis Investigative Site

City

Plovdiv

ZIP/Postal Code

4000

Country

Bulgaria

Facility Name

Novartis Investigative Site

City

Ruse

ZIP/Postal Code

7002

Country

Bulgaria

Facility Name

Novartis Investigative Site

City

Sliven

ZIP/Postal Code

8800

Country

Bulgaria

Facility Name

Novartis Investigative Site

City

Sofia

ZIP/Postal Code

1233

Country

Bulgaria

Facility Name

Novartis Investigative Site

City

Sofia

ZIP/Postal Code

1431

Country

Bulgaria

Facility Name

Novartis Investigative Site

City

Veliko Tarnovo

ZIP/Postal Code

5000

Country

Bulgaria

Facility Name

Novartis Investigative Site

City

Varazdin

State/Province

HRV

ZIP/Postal Code

42000

Country

Croatia

Facility Name

Novartis Investigative Site

City

Zagreb

ZIP/Postal Code

10000

Country

Croatia

Facility Name

Novartis Investigative Site

City

Brno

State/Province

Czech Republic

ZIP/Postal Code

656 91

Country

Czechia

Facility Name

Novartis Investigative Site

City

Decin II

State/Province

Czech Republic

ZIP/Postal Code

405 99

Country

Czechia

Facility Name

Novartis Investigative Site

City

Karvina-Raj

State/Province

Czech Republic

ZIP/Postal Code

73412

Country

Czechia

Facility Name

Novartis Investigative Site

City

Kromeriz

State/Province

Czech Republic

ZIP/Postal Code

767 55

Country

Czechia

Facility Name

Novartis Investigative Site

City

Melnik

State/Province

Czech Republic

ZIP/Postal Code

27601

Country

Czechia

Facility Name

Novartis Investigative Site

City

Pisek

State/Province

Czech Republic

ZIP/Postal Code

39701

Country

Czechia

Facility Name

Novartis Investigative Site

City

Svitavy

State/Province

Czech Republic

ZIP/Postal Code

568 25

Country

Czechia

Facility Name

Novartis Investigative Site

City

Tabor

State/Province

Czech Republic

ZIP/Postal Code

39003

Country

Czechia

Facility Name

Novartis Investigative Site

City

Trebic

State/Province

Czech Republic

ZIP/Postal Code

674 01

Country

Czechia

Facility Name

Novartis Investigative Site

City

Plzen

ZIP/Postal Code

301 00

Country

Czechia

Facility Name

Novartis Investigative Site

City

Prague 5

ZIP/Postal Code

150 06

Country

Czechia

Facility Name

Novartis Investigative Site

City

Tallinn

ZIP/Postal Code

13419

Country

Estonia

Facility Name

Novartis Investigative Site

City

Tartu

ZIP/Postal Code

51014

Country

Estonia

Facility Name

Novartis Investigative Site

City

Turku

ZIP/Postal Code

20520

Country

Finland

Facility Name

Novartis Investigative Site

City

Marseille cedex 20

State/Province

Bouches Du Rhone

ZIP/Postal Code

13915

Country

France

Facility Name

Novartis Investigative Site

City

Nancy

State/Province

Cedex

ZIP/Postal Code

54035

Country

France

Facility Name

Novartis Investigative Site

City

Abbeville

ZIP/Postal Code

80100

Country

France

Facility Name

Novartis Investigative Site

City

Agen Cedex 9

ZIP/Postal Code

47923

Country

France

Facility Name

Novartis Investigative Site

City

Amiens cedex 1

ZIP/Postal Code

80054

Country

France

Facility Name

Novartis Investigative Site

City

Avignon

ZIP/Postal Code

84000

Country

France

Facility Name

Novartis Investigative Site

City

Belfort

ZIP/Postal Code

90 016

Country

France

Facility Name

Novartis Investigative Site

City

Besancon Cedex

ZIP/Postal Code

25030

Country

France

Facility Name

Novartis Investigative Site

City

Brest

ZIP/Postal Code

29200

Country

France

Facility Name

Novartis Investigative Site

City

Bron

ZIP/Postal Code

69677

Country

France

Facility Name

Novartis Investigative Site

City

Chalon sur Saône

ZIP/Postal Code

71321

Country

France

Facility Name

Novartis Investigative Site

City

Chambray-lès-Tours

ZIP/Postal Code

37170

Country

France

Facility Name

Novartis Investigative Site

City

Chateauroux

ZIP/Postal Code

36000

Country

France

Facility Name

Novartis Investigative Site

City

Clermont-Ferrand

ZIP/Postal Code

63003

Country

France

Facility Name

Novartis Investigative Site

City

Corbeil Essonnes

ZIP/Postal Code

91100

Country

France

Facility Name

Novartis Investigative Site

City

Dunkerque

ZIP/Postal Code

59385

Country

France

Facility Name

Novartis Investigative Site

City

La Seyne sur mer

ZIP/Postal Code

83500

Country

France

Facility Name

Novartis Investigative Site

City

Le Coudray

ZIP/Postal Code

28630

Country

France

Facility Name

Novartis Investigative Site

City

Le Mans Cedex 09

ZIP/Postal Code

72037

Country

France

Facility Name

Novartis Investigative Site

City

Lens

ZIP/Postal Code

62307

Country

France

Facility Name

Novartis Investigative Site

City

Limoges Cedex

ZIP/Postal Code

87042

Country

France

Facility Name

Novartis Investigative Site

City

Lorient Cedex

ZIP/Postal Code

56322

Country

France

Facility Name

Novartis Investigative Site

City

Metz

ZIP/Postal Code

57085

Country

France

Facility Name

Novartis Investigative Site

City

Montauban

ZIP/Postal Code

82013

Country

France

Facility Name

Novartis Investigative Site

City

Montauban

ZIP/Postal Code

82017

Country

France

Facility Name

Novartis Investigative Site

City

Montpellier

ZIP/Postal Code

34295

Country

France

Facility Name

Novartis Investigative Site

City

Mulhouse cedex

ZIP/Postal Code

68070

Country

France

Facility Name

Novartis Investigative Site

City

Nimes Cedex 09

ZIP/Postal Code

30029

Country

France

Facility Name

Novartis Investigative Site

City

Niort

ZIP/Postal Code

79021

Country

France

Facility Name

Novartis Investigative Site

City

Orleans

ZIP/Postal Code

45100

Country

France

Facility Name

Novartis Investigative Site

City

Paris cedex 10

ZIP/Postal Code

75010

Country

France

Facility Name

Novartis Investigative Site

City

Paris

ZIP/Postal Code

75013

Country

France

Facility Name

Novartis Investigative Site

City

Paris

ZIP/Postal Code

75015

Country

France

Facility Name

Novartis Investigative Site

City

Pau

ZIP/Postal Code

64000

Country

France

Facility Name

Novartis Investigative Site

City

Poitiers

ZIP/Postal Code

86021

Country

France

Facility Name

Novartis Investigative Site

City

Périgueux

ZIP/Postal Code

24019

Country

France

Facility Name

Novartis Investigative Site

City

Rennes Cedex 9

ZIP/Postal Code

35033

Country

France

Facility Name

Novartis Investigative Site

City

Saint Brieuc

ZIP/Postal Code

22027

Country

France

Facility Name

Novartis Investigative Site

City

St Michel

ZIP/Postal Code

16470

Country

France

Facility Name

Novartis Investigative Site

City

St Priest en Jarez Cedex

ZIP/Postal Code

42277

Country

France

Facility Name

Novartis Investigative Site

City

Strasbourg Cedex

ZIP/Postal Code

67091

Country

France

Facility Name

Novartis Investigative Site

City

Troyes

ZIP/Postal Code

10003

Country

France

Facility Name

Novartis Investigative Site

City

Vienne

ZIP/Postal Code

38209

Country

France

Facility Name

Novartis Investigative Site

City

Flensburg

State/Province

Schleswig Holstein

ZIP/Postal Code

24939

Country

Germany

Facility Name

Novartis Investigative Site

City

Arnstadt

ZIP/Postal Code

99310

Country

Germany

Facility Name

Novartis Investigative Site

City

Bad Berka

ZIP/Postal Code

99438

Country

Germany

Facility Name

Novartis Investigative Site

City

Bad Oeynhausen

ZIP/Postal Code

32545

Country

Germany

Facility Name

Novartis Investigative Site

City

Baden-Baden

ZIP/Postal Code

76532

Country

Germany

Facility Name

Novartis Investigative Site

City

Berlin

ZIP/Postal Code

10405

Country

Germany

Facility Name

Novartis Investigative Site

City

Berlin

ZIP/Postal Code

12203

Country

Germany

Facility Name

Novartis Investigative Site

City

Berlin

ZIP/Postal Code

12526

Country

Germany

Facility Name

Novartis Investigative Site

City

Berlin

ZIP/Postal Code

12683

Country

Germany

Facility Name

Novartis Investigative Site

City

Berlin

ZIP/Postal Code

13187

Country

Germany

Facility Name

Novartis Investigative Site

City

Bernburg

ZIP/Postal Code

06406

Country

Germany

Facility Name

Novartis Investigative Site

City

Bochum

ZIP/Postal Code

44791

Country

Germany

Facility Name

Novartis Investigative Site

City

Buchholz in der Nordheide

ZIP/Postal Code

21244

Country

Germany

Facility Name

Novartis Investigative Site

City

Chemnitz

ZIP/Postal Code

09113

Country

Germany

Facility Name

Novartis Investigative Site

City

Chemnitz

ZIP/Postal Code

09117

Country

Germany

Facility Name

Novartis Investigative Site

City

Dorsten

ZIP/Postal Code

46282

Country

Germany

Facility Name

Novartis Investigative Site

City

Dortmund

ZIP/Postal Code

44263

Country

Germany

Facility Name

Novartis Investigative Site

City

Dortmund

ZIP/Postal Code

44309

Country

Germany

Facility Name

Novartis Investigative Site

City

Dortmund

ZIP/Postal Code

44379

Country

Germany

Facility Name

Novartis Investigative Site

City

Dresden

ZIP/Postal Code

01307

Country

Germany

Facility Name

Novartis Investigative Site

City

Duisburg

ZIP/Postal Code

47137

Country

Germany

Facility Name

Novartis Investigative Site

City

Duisburg

ZIP/Postal Code

47228

Country

Germany

Facility Name

Novartis Investigative Site

City

Düssledorf

ZIP/Postal Code

40217

Country

Germany

Facility Name

Novartis Investigative Site

City

Erfurt

ZIP/Postal Code

99089

Country

Germany

Facility Name

Novartis Investigative Site

City

Erfurt

ZIP/Postal Code

99097

Country

Germany

Facility Name

Novartis Investigative Site

City

Erlangen

ZIP/Postal Code

91054

Country

Germany

Facility Name

Novartis Investigative Site

City

Eschwege

ZIP/Postal Code

37269

Country

Germany

Facility Name

Novartis Investigative Site

City

Esslingen

ZIP/Postal Code

73730

Country

Germany

Facility Name

Novartis Investigative Site

City

Frankfurt

ZIP/Postal Code

60316

Country

Germany

Facility Name

Novartis Investigative Site

City

Frankfurt

ZIP/Postal Code

65929

Country

Germany

Facility Name

Novartis Investigative Site

City

Friesoythe

ZIP/Postal Code

26169

Country

Germany

Facility Name

Novartis Investigative Site

City

Gera

ZIP/Postal Code

07548

Country

Germany

Facility Name

Novartis Investigative Site

City

Gotha

ZIP/Postal Code

99867

Country

Germany

Facility Name

Novartis Investigative Site

City

Greifswald

ZIP/Postal Code

17475

Country

Germany

Facility Name

Novartis Investigative Site

City

Guetersloh

ZIP/Postal Code

33332

Country

Germany

Facility Name

Novartis Investigative Site

City

Hamburg

ZIP/Postal Code

22457

Country

Germany

Facility Name

Novartis Investigative Site

City

Heidelberg

ZIP/Postal Code

69120

Country

Germany

Facility Name

Novartis Investigative Site

City

Heidenheim

ZIP/Postal Code

89522

Country

Germany

Facility Name

Novartis Investigative Site

City

Hennigsdorf

ZIP/Postal Code

16761

Country

Germany

Facility Name

Novartis Investigative Site

City

Herford

ZIP/Postal Code

32049

Country

Germany

Facility Name

Novartis Investigative Site

City

Hoyerswerda

ZIP/Postal Code

02977

Country

Germany

Facility Name

Novartis Investigative Site

City

Kaufbeuren

ZIP/Postal Code

87600

Country

Germany

Facility Name

Novartis Investigative Site

City

Koblenz

ZIP/Postal Code

56073

Country

Germany

Facility Name

Novartis Investigative Site

City

Koeln-Nippes

ZIP/Postal Code

50733

Country

Germany

Facility Name

Novartis Investigative Site

City

Langen

ZIP/Postal Code

63225

Country

Germany

Facility Name

Novartis Investigative Site

City

Lemgo

ZIP/Postal Code

32657

Country

Germany

Facility Name

Novartis Investigative Site

City

Leverkusen

ZIP/Postal Code

51379

Country

Germany

Facility Name

Novartis Investigative Site

City

Lüneburg

ZIP/Postal Code

21339

Country

Germany

Facility Name

Novartis Investigative Site

City

Mannheim

ZIP/Postal Code

68167

Country

Germany

Facility Name

Novartis Investigative Site

City

Marburg

ZIP/Postal Code

35039

Country

Germany

Facility Name

Novartis Investigative Site

City

Marl

ZIP/Postal Code

45768

Country

Germany

Facility Name

Novartis Investigative Site

City

Memmingen

ZIP/Postal Code

87700

Country

Germany

Facility Name

Novartis Investigative Site

City

Moenchengladbach

ZIP/Postal Code

41063

Country

Germany

Facility Name

Novartis Investigative Site

City

Muelheim

ZIP/Postal Code

45468

Country

Germany

Facility Name

Novartis Investigative Site

City

Muenchen

ZIP/Postal Code

81379

Country

Germany

Facility Name

Novartis Investigative Site

City

Neumünster

ZIP/Postal Code

24534

Country

Germany

Facility Name

Novartis Investigative Site

City

Neunkirchen

ZIP/Postal Code

66538

Country

Germany

Facility Name

Novartis Investigative Site

City

Neuss

ZIP/Postal Code

41464

Country

Germany

Facility Name

Novartis Investigative Site

City

Neustadt A.d. Aisch

ZIP/Postal Code

91413

Country

Germany

Facility Name

Novartis Investigative Site

City

Neuwied

ZIP/Postal Code

56564

Country

Germany

Facility Name

Novartis Investigative Site

City

Nürnberg

ZIP/Postal Code

90419

Country

Germany

Facility Name

Novartis Investigative Site

City

Ribnitz-Damgarten

ZIP/Postal Code

18311

Country

Germany

Facility Name

Novartis Investigative Site

City

Rostock

ZIP/Postal Code

18057

Country

Germany

Facility Name

Novartis Investigative Site

City

Rotenburg

ZIP/Postal Code

27356

Country

Germany

Facility Name

Novartis Investigative Site

City

Schoenebeck

ZIP/Postal Code

39218

Country

Germany

Facility Name

Novartis Investigative Site

City

Schwabach

ZIP/Postal Code

91126

Country

Germany

Facility Name

Novartis Investigative Site

City

Schwalmstadt

ZIP/Postal Code

34613

Country

Germany

Facility Name

Novartis Investigative Site

City

Singen

ZIP/Postal Code

78224

Country

Germany

Facility Name

Novartis Investigative Site

City

Soest

ZIP/Postal Code

59494

Country

Germany

Facility Name

Novartis Investigative Site

City

Sonneberg

ZIP/Postal Code

96515

Country

Germany

Facility Name

Novartis Investigative Site

City

Speyer

ZIP/Postal Code

67346

Country

Germany

Facility Name

Novartis Investigative Site

City

Stade

ZIP/Postal Code

21682

Country

Germany

Facility Name

Novartis Investigative Site

City

Stadtlohn

ZIP/Postal Code

48703

Country

Germany

Facility Name

Novartis Investigative Site

City

Stuttgart

ZIP/Postal Code

70376

Country

Germany

Facility Name

Novartis Investigative Site

City

Suhl

ZIP/Postal Code

98527

Country

Germany

Facility Name

Novartis Investigative Site

City

Torgau

ZIP/Postal Code

04860

Country

Germany

Facility Name

Novartis Investigative Site

City

Trier

ZIP/Postal Code

54292

Country

Germany

Facility Name

Novartis Investigative Site

City

Tuebingen

ZIP/Postal Code

72076

Country

Germany

Facility Name

Novartis Investigative Site

City

Ulm

ZIP/Postal Code

89081

Country

Germany

Facility Name

Novartis Investigative Site

City

Vechta

ZIP/Postal Code

49377

Country

Germany

Facility Name

Novartis Investigative Site

City

Wesel

ZIP/Postal Code

46483

Country

Germany

Facility Name

Novartis Investigative Site

City

Witten

ZIP/Postal Code

58455

Country

Germany

Facility Name

Novartis Investigative Site

City

Worms

ZIP/Postal Code

67550

Country

Germany

Facility Name

Novartis Investigative Site

City

Wuerzburg

ZIP/Postal Code

97078

Country

Germany

Facility Name

Novartis Investigative Site

City

Wuppertal

ZIP/Postal Code

42109

Country

Germany

Facility Name

Novartis Investigative Site

City

Wurzen

ZIP/Postal Code

04808

Country

Germany

Facility Name

Novartis Investigative Site

City

Alexandroupolis

State/Province

Evros

ZIP/Postal Code

681 00

Country

Greece

Facility Name

Novartis Investigative Site

City

Voula

State/Province

ZIP/Postal Code

166 73

Country

Greece

Facility Name

Novartis Investigative Site

City

Athens

ZIP/Postal Code

115 21

Country

Greece

Facility Name

Novartis Investigative Site

City

Athens

ZIP/Postal Code

115 27

Country

Greece

Facility Name

Novartis Investigative Site

City

Athens

ZIP/Postal Code

115 28

Country

Greece

Facility Name

Novartis Investigative Site

City

Volos

ZIP/Postal Code

GR 38222

Country

Greece

Facility Name

Novartis Investigative Site

City

Budapest

ZIP/Postal Code

1096

Country

Hungary

Facility Name

Novartis Investigative Site

City

Budapest

ZIP/Postal Code

H 1096

Country

Hungary

Facility Name

Novartis Investigative Site

City

Budapest

ZIP/Postal Code

H-1032

Country

Hungary

Facility Name

Novartis Investigative Site

City

Budapest

ZIP/Postal Code

H-1115

Country

Hungary

Facility Name

Novartis Investigative Site

City

Debrecen

ZIP/Postal Code

4032

Country

Hungary

Facility Name

Novartis Investigative Site

City

Eger

ZIP/Postal Code

H-3300

Country

Hungary

Facility Name

Novartis Investigative Site

City

Gyor

ZIP/Postal Code

H-9023

Country

Hungary

Facility Name

Novartis Investigative Site

City

Kalocsa

ZIP/Postal Code

6300

Country

Hungary

Facility Name

Novartis Investigative Site

City

Kecskemet

ZIP/Postal Code

6000

Country

Hungary

Facility Name

Novartis Investigative Site

City

Kistarcsa

ZIP/Postal Code

2143

Country

Hungary

Facility Name

Novartis Investigative Site

City

Mako

ZIP/Postal Code

6900

Country

Hungary

Facility Name

Novartis Investigative Site

City

Szeged

ZIP/Postal Code

H-6725

Country

Hungary

Facility Name

Novartis Investigative Site

City

Szolnok

ZIP/Postal Code

5004

Country

Hungary

Facility Name

Novartis Investigative Site

City

Reykjavik

ZIP/Postal Code

IS-101

Country

Iceland

Facility Name

Novartis Investigative Site

City

San Benedetto del Tronto

State/Province

ZIP/Postal Code

63039

Country

Italy

Facility Name

Novartis Investigative Site

City

Arezzo

State/Province

ZIP/Postal Code

52100

Country

Italy

Facility Name

Novartis Investigative Site

City

Acquaviva delle Fonti

State/Province

ZIP/Postal Code

70021

Country

Italy

Facility Name

Novartis Investigative Site

City

Altamura

State/Province

ZIP/Postal Code

70022

Country

Italy

Facility Name

Novartis Investigative Site

City

Cassano delle Murge

State/Province

ZIP/Postal Code

70020

Country

Italy

Facility Name

Novartis Investigative Site

City

Treviglio

State/Province

ZIP/Postal Code

24047

Country

Italy

Facility Name

Novartis Investigative Site

City

Cagliari

State/Province

ZIP/Postal Code

09134

Country

Italy

Facility Name

Novartis Investigative Site

City

Catania

State/Province

ZIP/Postal Code

95100

Country

Italy

Facility Name

Novartis Investigative Site

City

Lodi

State/Province

ZIP/Postal Code

26900

Country

Italy

Facility Name

Novartis Investigative Site

City

Latina

State/Province

ZIP/Postal Code

04100

Country

Italy

Facility Name

Novartis Investigative Site

City

Messina

State/Province

ZIP/Postal Code

98125

Country

Italy

Facility Name

Novartis Investigative Site

City

Cernusco sul Naviglio

State/Province

ZIP/Postal Code

20063

Country

Italy

Facility Name

Novartis Investigative Site

City

Legnano

State/Province

ZIP/Postal Code

20025

Country

Italy

Facility Name

Novartis Investigative Site

City

Matera

State/Province

Mount

ZIP/Postal Code

75100

Country

Italy

Facility Name

Novartis Investigative Site

City

Piacenza

State/Province

ZIP/Postal Code

29100

Country

Italy

Facility Name

Novartis Investigative Site

City

Pordenone

State/Province

ZIP/Postal Code

33170

Country

Italy

Facility Name

Novartis Investigative Site

City

Reggio Emilia

State/Province

ZIP/Postal Code

42123

Country

Italy

Facility Name

Novartis Investigative Site

City

Scandiano

State/Province

ZIP/Postal Code

42019

Country

Italy

Facility Name

Novartis Investigative Site

City

Roma

State/Province

ZIP/Postal Code

00135

Country

Italy

Facility Name

Novartis Investigative Site

City

Roma

State/Province

ZIP/Postal Code

00152

Country

Italy

Facility Name

Novartis Investigative Site

City

Roma

State/Province

ZIP/Postal Code

00177

Country

Italy

Facility Name

Novartis Investigative Site

City

Roma

State/Province

ZIP/Postal Code

00189

Country

Italy

Facility Name

Novartis Investigative Site

City

Siena

State/Province

ZIP/Postal Code

53100

Country

Italy

Facility Name

Novartis Investigative Site

City

Siracusa

State/Province

ZIP/Postal Code

96100

Country

Italy

Facility Name

Novartis Investigative Site

City

Sassari

State/Province

ZIP/Postal Code

07100

Country

Italy

Facility Name

Novartis Investigative Site

City

Orbassano

State/Province

ZIP/Postal Code

10043

Country

Italy

Facility Name

Novartis Investigative Site

City

Torino

State/Province

ZIP/Postal Code

10153

Country

Italy

Facility Name

Novartis Investigative Site

City

Torino

State/Province

ZIP/Postal Code

10154

Country

Italy

Facility Name

Novartis Investigative Site

City

Busto Arsizio

State/Province

ZIP/Postal Code

21052

Country

Italy

Facility Name

Novartis Investigative Site

City

Chioggia

State/Province

ZIP/Postal Code

30015

Country

Italy

Facility Name

Novartis Investigative Site

City

Vicenza

State/Province

ZIP/Postal Code

36100

Country

Italy

Facility Name

Novartis Investigative Site

City

Verona

State/Province

ZIP/Postal Code

37134

Country

Italy

Facility Name

Novartis Investigative Site

City

Vibo Valentia

State/Province

ZIP/Postal Code

89900

Country

Italy

Facility Name

Novartis Investigative Site

City

Pozzuoli

ZIP/Postal Code

80078

Country

Italy

Facility Name

Novartis Investigative Site

City

Daugavpils

ZIP/Postal Code

LV-5417

Country

Latvia

Facility Name

Novartis Investigative Site

City

Kaunas

State/Province

LTU

ZIP/Postal Code

LT-50161

Country

Lithuania

Facility Name

Novartis Investigative Site

City

Kaunas

State/Province

ZIP/Postal Code

LT-45130

Country

Lithuania

Facility Name

Novartis Investigative Site

City

Klaipeda

ZIP/Postal Code

92288

Country

Lithuania

Facility Name

Novartis Investigative Site

City

Vilnius

ZIP/Postal Code

LT-08661

Country

Lithuania

Facility Name

Novartis Investigative Site

City

Krakow

State/Province

POL

ZIP/Postal Code

31-121

Country

Poland

Facility Name

Novartis Investigative Site

City

Bilgoraj

ZIP/Postal Code

23-400

Country

Poland

Facility Name

Novartis Investigative Site

City

Gdansk

ZIP/Postal Code

80 952

Country

Poland

Facility Name

Novartis Investigative Site

City

Grodzisk Mazowiecki

ZIP/Postal Code

05-825

Country

Poland

Facility Name

Novartis Investigative Site

City

Kielce

ZIP/Postal Code

25-317

Country

Poland

Facility Name

Novartis Investigative Site

City

Krakow

ZIP/Postal Code

30-901

Country

Poland

Facility Name

Novartis Investigative Site

City

Krakow

ZIP/Postal Code

31 501

Country

Poland

Facility Name

Novartis Investigative Site

City

Lubin

ZIP/Postal Code

59-301

Country

Poland

Facility Name

Novartis Investigative Site

City

Lublin

ZIP/Postal Code

20-718

Country

Poland

Facility Name

Novartis Investigative Site

City

Oswiecim

ZIP/Postal Code

32-600

Country

Poland

Facility Name

Novartis Investigative Site

City

Rzeszow

ZIP/Postal Code

35-241

Country

Poland

Facility Name

Novartis Investigative Site

City

Tarnobrzeg

ZIP/Postal Code

39-400

Country

Poland

Facility Name

Novartis Investigative Site

City

Tarnow

ZIP/Postal Code

33-100

Country

Poland

Facility Name

Novartis Investigative Site

City

Walbrzych

ZIP/Postal Code

58-309

Country

Poland

Facility Name

Novartis Investigative Site

City

Almada

ZIP/Postal Code

2801 951

Country

Portugal

Facility Name

Novartis Investigative Site

City

Barreiro

ZIP/Postal Code

2834-003

Country

Portugal

Facility Name

Novartis Investigative Site

City

Braga

ZIP/Postal Code

4710243

Country

Portugal

Facility Name

Novartis Investigative Site

City

Lisboa

ZIP/Postal Code

1495-005

Country

Portugal

Facility Name

Novartis Investigative Site

City

Lisboa

ZIP/Postal Code

1500 650

Country

Portugal

Facility Name

Novartis Investigative Site

City

Matosinhos

ZIP/Postal Code

4454-509

Country

Portugal

Facility Name

Novartis Investigative Site

City

Setubal

ZIP/Postal Code

2910-446

Country

Portugal

Facility Name

Novartis Investigative Site

City

Vila Franca de Xira

ZIP/Postal Code

2600-009

Country

Portugal

Facility Name

Novartis Investigative Site

City

Bucuresti

State/Province

District 4

ZIP/Postal Code

4204179

Country

Romania

Facility Name

Novartis Investigative Site

City

Bucharest

State/Province

Jud Cluj

ZIP/Postal Code

010825

Country

Romania

Facility Name

Novartis Investigative Site

City

Craiova

State/Province

Jud. Iasi

ZIP/Postal Code

200642

Country

Romania

Facility Name

Novartis Investigative Site

City

Bucharest

ZIP/Postal Code

022322

Country

Romania

Facility Name

Novartis Investigative Site

City

Sibiu

ZIP/Postal Code

550245

Country

Romania

Facility Name

Novartis Investigative Site

City

Tirgoviste

ZIP/Postal Code

130095

Country

Romania

Facility Name

Novartis Investigative Site

City

Chelyabinsk

ZIP/Postal Code

454000

Country

Russian Federation

Facility Name

Novartis Investigative Site

City

Chelyabinsk

ZIP/Postal Code

454092

Country

Russian Federation

Facility Name

Novartis Investigative Site

City

Chita

ZIP/Postal Code

672039

Country

Russian Federation

Facility Name

Novartis Investigative Site

City

Gatchina

ZIP/Postal Code

188300

Country

Russian Federation

Facility Name

Novartis Investigative Site

City

Izhevsk

ZIP/Postal Code

426009

Country

Russian Federation

Facility Name

Novartis Investigative Site

City

Kazan

ZIP/Postal Code

420012

Country

Russian Federation

Facility Name

Novartis Investigative Site

City

Kazan

ZIP/Postal Code

420103

Country

Russian Federation

Facility Name

Novartis Investigative Site

City

Kirov

ZIP/Postal Code

610027

Country

Russian Federation

Facility Name

Novartis Investigative Site

City

Krasnoyarsk

ZIP/Postal Code

660022

Country

Russian Federation

Facility Name

Novartis Investigative Site

City

Moscow

ZIP/Postal Code

115280

Country

Russian Federation

Facility Name

Novartis Investigative Site

City

Moscow

ZIP/Postal Code

117997

Country

Russian Federation

Facility Name

Novartis Investigative Site

City

Moscow

ZIP/Postal Code

121359

Country

Russian Federation

Facility Name

Novartis Investigative Site

City

Moscow

ZIP/Postal Code

127473

Country

Russian Federation

Facility Name

Novartis Investigative Site

City

Moscow

ZIP/Postal Code

127994

Country

Russian Federation

Facility Name

Novartis Investigative Site

City

Novosibirsk

ZIP/Postal Code

630003

Country

Russian Federation

Facility Name

Novartis Investigative Site

City

Penza

ZIP/Postal Code

440026

Country

Russian Federation

Facility Name

Novartis Investigative Site

City

Petrozavodsk

ZIP/Postal Code

185031

Country

Russian Federation

Facility Name

Novartis Investigative Site

City

Rostov-on-Don

ZIP/Postal Code

344068

Country

Russian Federation

Facility Name

Novartis Investigative Site

City

Ryazan

ZIP/Postal Code

390026

Country

Russian Federation

Facility Name

Novartis Investigative Site

City

Saint-Petersburg

ZIP/Postal Code

194044

Country

Russian Federation

Facility Name

Novartis Investigative Site

City

Saratov

ZIP/Postal Code

410028

Country

Russian Federation

Facility Name

Novartis Investigative Site

City

St.-Petersburg

ZIP/Postal Code

194044

Country

Russian Federation

Facility Name

Novartis Investigative Site

City

Tyumen

ZIP/Postal Code

625023

Country

Russian Federation

Facility Name

Novartis Investigative Site

City

Ufa

ZIP/Postal Code

450071

Country

Russian Federation

Facility Name

Novartis Investigative Site

City

Vladivostok

ZIP/Postal Code

690002

Country

Russian Federation

Facility Name

Novartis Investigative Site

City

Volgograd

ZIP/Postal Code

400008

Country

Russian Federation

Facility Name

Novartis Investigative Site

City

Yaroslavl

ZIP/Postal Code

150047

Country

Russian Federation

Facility Name

Novartis Investigative Site

City

Zelenograd, Moscow Region

ZIP/Postal Code

124489

Country

Russian Federation

Facility Name

Novartis Investigative Site

City

Belgrade

ZIP/Postal Code

11 000

Country

Serbia

Facility Name

Novartis Investigative Site

City

Belgrade

ZIP/Postal Code

11000

Country

Serbia

Facility Name

Novartis Investigative Site

City

Belgrade

ZIP/Postal Code

11080

Country

Serbia

Facility Name

Novartis Investigative Site

City

Kamenica

ZIP/Postal Code

21204

Country

Serbia

Facility Name

Novartis Investigative Site

City

Niska Banja

ZIP/Postal Code

18205

Country

Serbia

Facility Name

Novartis Investigative Site

City

Nis

ZIP/Postal Code

18000

Country

Serbia

Facility Name

Novartis Investigative Site

City

Dunajska Streda

State/Province

Slovak Republic

ZIP/Postal Code

92901

Country

Slovakia

Facility Name

Novartis Investigative Site

City

Skalica

State/Province

Slovak Republic

ZIP/Postal Code

909 82

Country

Slovakia

Facility Name

Novartis Investigative Site

City

Zvolen

State/Province

Slovak Republic

ZIP/Postal Code

96001

Country

Slovakia

Facility Name

Novartis Investigative Site

City

Brezno

ZIP/Postal Code

97701

Country

Slovakia

Facility Name

Novartis Investigative Site

City

Poprad

ZIP/Postal Code

05845

Country

Slovakia

Facility Name

Novartis Investigative Site

City

Trencin

ZIP/Postal Code

91171

Country

Slovakia

Facility Name

Novartis Investigative Site

City

Celje

ZIP/Postal Code

3000

Country

Slovenia

Facility Name

Novartis Investigative Site

City

Jesenice

ZIP/Postal Code

4270

Country

Slovenia

Facility Name

Novartis Investigative Site

City

Ljubljana

ZIP/Postal Code

1000

Country

Slovenia

Facility Name

Novartis Investigative Site

City

Murska Sobota

ZIP/Postal Code

9000

Country

Slovenia

Facility Name

Novartis Investigative Site

City

Granada

State/Province

Andalucia

ZIP/Postal Code

18012

Country

Spain

Facility Name

Novartis Investigative Site

City

Granada

State/Province

Andalucia

ZIP/Postal Code

18014

Country

Spain

Facility Name

Novartis Investigative Site

City

Malaga

State/Province

Andalucia

ZIP/Postal Code

29010

Country

Spain

Facility Name

Novartis Investigative Site

City

Sanlucar de Barrameda

State/Province

Andalucia

ZIP/Postal Code

11540

Country

Spain

Facility Name

Novartis Investigative Site

City

Sevilla

State/Province

Andalucia

ZIP/Postal Code

41009

Country

Spain

Facility Name

Novartis Investigative Site

City

Sevilla

State/Province

Andalucia

ZIP/Postal Code

41013

Country

Spain

Facility Name

Novartis Investigative Site

City

Sevilla

State/Province

Andalucia

ZIP/Postal Code

41014

Country

Spain

Facility Name

Novartis Investigative Site

City

Oviedo

State/Province

Asturias

ZIP/Postal Code

33006

Country

Spain

Facility Name

Novartis Investigative Site

City

Villamartin

State/Province

Cadiz

ZIP/Postal Code

11650

Country

Spain

Facility Name

Novartis Investigative Site

City

Toledo

State/Province

Castilla La Mancha

ZIP/Postal Code

45071

Country

Spain

Facility Name

Novartis Investigative Site

City

Salamanca

State/Province

Castilla Y Leon

ZIP/Postal Code

37007

Country

Spain

Facility Name

Novartis Investigative Site

City

Soria

State/Province

Castilla Y Leon

ZIP/Postal Code

42005

Country

Spain

Facility Name

Novartis Investigative Site

City

Lleida

State/Province

Cataluna

ZIP/Postal Code

25198

Country

Spain

Facility Name

Novartis Investigative Site

City

Barcelona

State/Province

Catalunya

ZIP/Postal Code

08036

Country

Spain

Facility Name

Novartis Investigative Site

City

Terrassa

State/Province

Catalunya

ZIP/Postal Code

08227

Country

Spain

Facility Name

Novartis Investigative Site

City

Alicante

State/Province

Comunidad Valenciana

ZIP/Postal Code

03010

Country

Spain

Facility Name

Novartis Investigative Site

City

Alicante

State/Province

Comunidad Valenciana

ZIP/Postal Code

03550

Country

Spain

Facility Name

Novartis Investigative Site

City

Alzira

State/Province

Comunidad Valenciana

ZIP/Postal Code

46600

Country

Spain

Facility Name

Novartis Investigative Site

City

Valencia

State/Province

Comunidad Valenciana

ZIP/Postal Code

46010

Country

Spain

Facility Name

Novartis Investigative Site

City

Valencia

State/Province

Comunidad Valenciana

ZIP/Postal Code

46014

Country

Spain

Facility Name

Novartis Investigative Site

City

Valencia

State/Province

Comunidad Valenciana

ZIP/Postal Code

46015

Country

Spain

Facility Name

Novartis Investigative Site

City

Valencia

State/Province

Comunidad Valenciana

ZIP/Postal Code

46017

Country

Spain

Facility Name

Novartis Investigative Site

City

Caceres

State/Province

Extremadura

ZIP/Postal Code

10003

Country

Spain

Facility Name

Novartis Investigative Site

City

La Coruna

State/Province

Galicia

ZIP/Postal Code

15006

Country

Spain

Facility Name

Novartis Investigative Site

City

Santiago de Compostela

State/Province

Galicia

ZIP/Postal Code

15706

Country

Spain

Facility Name

Novartis Investigative Site

City

Las Palmas de Gran Canaria

State/Province

Las Palmas De G.C

ZIP/Postal Code

35010

Country

Spain

Facility Name

Novartis Investigative Site

City

Alcorcon

State/Province

Madrid

ZIP/Postal Code

28922

Country

Spain

Facility Name

Novartis Investigative Site

City

Fuenlabrada

State/Province

Madrid

ZIP/Postal Code

28942

Country

Spain

Facility Name

Novartis Investigative Site

City

Cartagena

State/Province

Murcia

ZIP/Postal Code

30202

Country

Spain

Facility Name

Novartis Investigative Site

City

El Palmar

State/Province

Murcia

ZIP/Postal Code

30120

Country

Spain

Facility Name

Novartis Investigative Site

City

Bilbao

State/Province

Pais Vasco

ZIP/Postal Code

48013

Country

Spain

Facility Name

Novartis Investigative Site

City

Galdakano

State/Province

Pais Vasco

ZIP/Postal Code

48960

Country

Spain

Facility Name

Novartis Investigative Site

City

La Laguna

State/Province

Santa Cruz De Tenerife

ZIP/Postal Code

38320

Country

Spain

Facility Name

Novartis Investigative Site

City

Manises

State/Province

Valencia

ZIP/Postal Code

46940

Country

Spain

Facility Name

Novartis Investigative Site

City

Leon

ZIP/Postal Code

24080

Country

Spain

Facility Name

Novartis Investigative Site

City

Madrid

ZIP/Postal Code

28006

Country

Spain

Facility Name

Novartis Investigative Site

City

Madrid

ZIP/Postal Code

28040

Country

Spain

Facility Name

Novartis Investigative Site

City

Murcia

ZIP/Postal Code

30003

Country

Spain

Facility Name

Novartis Investigative Site

City

Zaragoza

ZIP/Postal Code

50009

Country

Spain

Facility Name

Novartis Investigative Site

City

Basel

ZIP/Postal Code

4031

Country

Switzerland

Facility Name

Novartis Investigative Site

City

Geneve 14

ZIP/Postal Code

1211

Country

Switzerland

Facility Name

Novartis Investigative Site

City

Liestal

ZIP/Postal Code

4410

Country

Switzerland

Facility Name

Novartis Investigative Site

City

Lugano

ZIP/Postal Code

6903

Country

Switzerland

Facility Name

Novartis Investigative Site

City

Durham

State/Province

County Durham

ZIP/Postal Code

DH1 5TW

Country

United Kingdom

Facility Name

Novartis Investigative Site

City

Dorchester

State/Province

Dorset

ZIP/Postal Code

DT1 2JY

Country

United Kingdom

Facility Name

Novartis Investigative Site

City

Peterborough

State/Province

GBR

ZIP/Postal Code

PE3 6DA

Country

United Kingdom

Facility Name

Novartis Investigative Site

City

Gateshead

State/Province

Tyne And Wear

ZIP/Postal Code

NE9 6SX

Country

United Kingdom

Facility Name

Novartis Investigative Site

City

Barnet

ZIP/Postal Code

EN5 3DJ

Country

United Kingdom

Facility Name

Novartis Investigative Site

City

Cardiff

ZIP/Postal Code

CF14 4XW

Country

United Kingdom

Facility Name

Novartis Investigative Site

City

Dundee

ZIP/Postal Code

DD1 9SY

Country

United Kingdom

Facility Name

Novartis Investigative Site

City

Liverpool

ZIP/Postal Code

L9 7AL

Country

United Kingdom

Facility Name

Novartis Investigative Site

City

London

ZIP/Postal Code

SW17 ORE

Country

United Kingdom

Facility Name

Novartis Investigative Site

City

Swindon

ZIP/Postal Code

SN3 6BB

Country

United Kingdom

12. IPD Sharing Statement

Citations:

PubMed Identifier

35184572

Citation

Grand J, Miger K, Sajadieh A, Kober L, Torp-Pedersen C, Ertl G, Lopez-Sendon J, Pietro Maggioni A, Teerlink JR, Sato N, Gimpelewicz C, Metra M, Holbro T, Nielsen OW. Blood Pressure Drops During Hospitalization for Acute Heart Failure Treated With Serelaxin: A Patient-Level Analysis of 4 Randomized Controlled Trials. Circ Heart Fail. 2022 Apr;15(4):e009199. doi: 10.1161/CIRCHEARTFAILURE.121.009199. Epub 2022 Feb 21.

Results Reference

derived

PubMed Identifier

34514815

Citation

Grand J, Miger K, Sajadieh A, Kober L, Torp-Pedersen C, Ertl G, Lopez-Sendon J, Pietro Maggioni A, Teerlink JR, Sato N, Gimpelewicz C, Metra M, Holbro T, Nielsen OW. Systolic Blood Pressure and Outcome in Patients Admitted With Acute Heart Failure: An Analysis of Individual Patient Data From 4 Randomized Clinical Trials. J Am Heart Assoc. 2021 Sep 21;10(18):e022288. doi: 10.1161/JAHA.121.022288. Epub 2021 Sep 13.

Results Reference

derived

Learn more about this trial

Effect of Serelaxin Versus Standard of Care in Acute Heart Failure (AHF) Patients

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Effect of Serelaxin Versus Standard of Care in Acute Heart Failure (AHF) Patients (RELAX-AHF-EU)

Acute Heart Failure (AHF)

About this trial

Eligibility Criteria

Sites / Locations

Arms of the Study

Arm 1

Arm 2

Outcomes

Primary Outcome Measures

Secondary Outcome Measures

Full Information

1. Study Identification

2. Study Status

3. Sponsor/Collaborators

4. Oversight

5. Study Description

6. Conditions and Keywords

7. Study Design

8. Arms, Groups, and Interventions

10. Eligibility

12. IPD Sharing Statement

Learn more about this trial