Effect of Synchronized vs. Continuous HFNC Using NAVA on WOB in Infants With BPD
Bronchopulmonary Dysplasia
About this trial
This is an interventional treatment trial for Bronchopulmonary Dysplasia
Eligibility Criteria
Inclusion Criteria:
- Chronological age greater than 28 days
- Gestational age at birth less than 32 weeks and 6 days
- Diagnosis of BPD (supplemental oxygen requirement for greater than or equal to 28 days)
- Currently receiving noninvasive ventilation support (NIV NAVA, NIPPV, nCPAP, HFNC)
Exclusion Criteria:
- Major congenital anomalies of the heart and lungs
- Post menstrual age greater than 50 weeks 0 days
- Oxygen requirement greater than 40%
Sites / Locations
- Arkansas Children's Hospital
Arms of the Study
Arm 1
Arm 2
Experimental
Active Comparator
Alternating between Synchronized and Continuous HFNC at 6 and 8 LPM (starting with synchronized)
Alternating between Synchronized and Continuous HFNC at 6 and 8 LPM (starting with continuous)
Subjects will first receive HFNC synchronized to his/her own efforts via NAVA at 6 LPM followed by continuous HFNC at 6 LPM and then HFNC synchronized to his/her own efforts via NAVA at 8 LPM followed by continuous HFNC at 8 LPM
Subjects will first receive continuous HFNC at 6 LPM followed by HFNC synchronized to his/her own efforts via NAVA at 6 LPM. Next, subjects will receive continuous HFNC at 8 LPM followed by HFNC synchronized to his/her own efforts via NAVA at 8 LPM.