Effectiveness of Sertraline in Treating Pathological Gamblers With a Diagnosis of Alcohol Dependence - 1
Alcoholism, Gambling
About this trial
This is an interventional treatment trial for Alcoholism focused on measuring Gambling, Alcohol
Eligibility Criteria
Inclusion Criteria: Meets DSM-IV criteria for pathological gambling Meets DSM-IV and SCID criteria for alcohol abuse or dependence Medically healthy Exclusion Criteria: History of schizophrenia, schizoaffective disorder, or bipolar disorder Current diagnosis of substance abuse or dependence, other than alcohol or nicotine Current major depression Currently suicidal History of non-response to an adequate trial of sertraline, defined as 200 mg per day of sertraline for at least a 4-week period Previous treatment with relapse prevention therapy for pathological gambling or alcohol dependence within the 3 months prior to study entry Requires treatment with psychotropic medication Unwilling to consent to a drug-free period, according to the following: 2 weeks of abstinence from antidepressant drugs, other than fluoxetine, buspirone, lithium, anticonvulsants, barbiturates, opiates, or benzodiazepines; 4 weeks of abstinence from clonazepam; 5 weeks of abstinence from fluoxetine Clinically significant disorder, including kidney, pulmonary, cerebral vascular, cardiovascular, gastrointestinal, and endocrine disorders Abnormal laboratory tests Abnormal electrocardiogram Pregnant or breastfeeding Unwilling to use an adequate method of contraception for the duration of the study
Sites / Locations
Arms of the Study
Arm 1
Arm 2
Placebo Comparator
Active Comparator
Placebo and Relapse Prevention
Sertraline and Relapse Prevention
Patients will be treated with Relapse Prevention Therapy plus placebo
Patients will be treated with Relapse Prevention Therapy plus Sertraline.