Effects Of Adjunctive Photodynamic Therapy To Non-Surgical Periodontal Treatment In Patients With Generalized Aggressive Periodontitis
Generalized Aggressive Periodontitis
About this trial
This is an interventional treatment trial for Generalized Aggressive Periodontitis
Eligibility Criteria
Inclusion Criteria:
- systemically healthy,
- non-smoker
- not received any periodontal treatment within the last 6 months
- no antibiotics, anti-inflammatory drugs or any other medication taken within the last 6 months
- consent to participate in the study
Exclusion Criteria:
- any systemic disease (i.e. diabetes mellitus, HIV infection) that might influence the prognosis of periodontal disease and outcome of the treatment
- any medical condition that required antibiotic prophylaxis before the treatment
- smoking
- pregnancy and lactation
- ingestion of antibiotics, anti-inflammatory drugs or any other medication during study period
- any physical limitations or restrictions that might preclude normal oral hygiene procedures
Sites / Locations
Arms of the Study
Arm 1
Arm 2
Active Comparator
Experimental
Control Group
Test Group
NPT including scaling and root planing was applied to 12 subjects with ultrasonic and hand instruments until the operator feels that root surface is clean, hard and smooth.
Following NPT, toluidine blue O mediated PDT was performed with a LED source (625-635 nm wavelength) (FotoSan®, CMS Dental, Denmark) to 12 subjects. The dye (0.1 mg/ml) was applied with a canula into the periodontal pockets. After 3 minutes, the subjects rinsed their mouths with sterile saline solution for removal of excessive dye. Then, the applicator of photosensitizer was inserted until the bottom of the periodontal pocket and photoinactivation was performed in 6 sites per tooth for 10 seconds of each sites with a total of 60 seconds per tooth.