Effects of Creatine Supplementation in Rett Syndrome
Rett Syndrome
About this trial
This is an interventional basic science trial for Rett Syndrome focused on measuring Rett Syndrome, Randomized, Methylation
Eligibility Criteria
Inclusion Criteria:
- RTT Syndrome, diagnosed by current consensus criteria
Exclusion Criteria:
- taking supplements containing either folic acid or vitamin B12 or knowingly consuming any vitamin-fortified food items
Sites / Locations
- Medical University Vienna, Dep. of Pediatric and Adolescent Medicine
Arms of the Study
Arm 1
Arm 2
Active Comparator
Placebo Comparator
Creatine monohydrate
Placebo
The patients received orally 200 mg CMH per kg body weight divided in three doses per day. Following period 1 (6 months) of supplementation and a wash-out period of 4 weeks without CMH respectively the groups were switched for another 6 months (period 2).
The patients received orally 200 mg Placebo per kg body weight divided in three doses per day in identically prepared capsules. Following period 1 (6 months) of supplementation and a wash-out period of 4 weeks without Placebo respectively the groups were switched for another 6 months (period 2).