Effects of Different Centrifuged Platelet Concentrates on Bone Remodelling Around Dental Implants
Edentulous Jaw, Bone Loss, Alveolar, Resorption, Bone
About this trial
This is an interventional treatment trial for Edentulous Jaw focused on measuring Concentrated Growth Factor, Advanced Platelet Rich Fibrin, Inflammatory Cytokines, Implant Osseointegration, Peri-implant Crevicular Fluid
Eligibility Criteria
Inclusion Criteria:
- Above 18 years of age
- Symmetrical edentulous areas in the mandible
- Sufficient bone width and height permitting ideal dental implant placement
- Individuals who do not smoke
- At least 2 mm of keratinized gingiva width and 3 mm soft tissue thickness at the implant site
Exclusion Criteria:
- Patients with systemic disorders, including diabetes mellitus, metabolic bone disease, rheumatoid arthritis, mucocutaneous disorders, immunological disorders, hepatitis, or HIV
- Individuals who were on antibiotics, anti-inflammatory agents, corticosteroids, immunosuppressants, anticoagulants, or hormonal contraceptives for any reason, at least 6 months prior to the procedure, and those who were on bisphosphonates at that time or previously.
- Individuals with any pathology or defects at the implant site.
- History augmentation at the implant site.
- Individuals with severe periodontal disease and poor oral hygiene.
- Severe caries or endodontic lesions in teeth adjacent to the implant.
- Those who use intraoral orthodontic or prosthetic appliances that make plaque control difficult.
- Pregnant and lactating individuals.
Sites / Locations
- Mustafa Kemal University
Arms of the Study
Arm 1
Arm 2
Arm 3
Arm 4
Experimental
Experimental
Experimental
Experimental
CGF TEST GROUP
A-PRF TEST GROUP
CGF CONTROL GROUP
A-PRF CONTROL GROUP
Concentrated growth factor liquid applied into the implant cavity. Also CGF membrane covered the implant and the socket. That is the only difference between CGF control group and CGF test group
Advanced Platelet Rich Fibrin liquid applied into the implant cavity. Also A-PRF membrane covered the implant and the socket. That is the only difference between A-PRF control group and A-PRF test group
Dental implant applications were made with traditional methods.
Dental implant applications were made with traditional methods.