Effects of Electronic Cigarettes on Lung Biology
Lung Disease, Lung Disorder
About this trial
This is an interventional basic science trial for Lung Disease focused on measuring E-Cigarettes, Lung, Non-Smokers, Lung Biology
Eligibility Criteria
Inclusion Criteria:
- Males and females, age 21 or older
- Must be capable of providing informed consent
- Self-reported never-smokers, with current smoking status validated by the absence of nicotine metabolites in urine (nicotine <2 ng/ml and cotinine <5 ng/ml)
- Normal physical examination
- Good overall health without history of chronic lung disease, including asthma, and without recurrent or recent (within 3 months) acute pulmonary disease
- Normal routine laboratory evaluation, including general hematologic studies, general serologic/immunologic studies, general biochemical analyses, and urine analysis
- Not taking any medications relevant to lung disease or having an effect on the airway epithelium
- Negative HIV serology
- Normal chest X-ray (PA and lateral)
- Normal electrocardiogram (sinus bradycardia, premature atrial contractions are permissible)
- Females - not pregnant
- No history of allergies to medications to be used in the bronchoscopy procedure
- Willingness to participate in the study
Exclusion Criteria:
- Unable to meet the inclusion criteria
- Current active infection or acute illness of any kind
- Evidence of malignancy within the past 5 years
- Current alcohol or drug abuse
- Pregnancy
Sites / Locations
- Weill Cornell Medical College
Arms of the Study
Arm 1
Arm 2
Arm 3
Arm 4
Arm 5
Experimental
Experimental
Experimental
Experimental
Experimental
Group A
Group B
Group C
Group D
Group E
Electronic cigarette (nicotine/placebo) - Day 8 Intervention: Electronic cigarette exposure will be limited to one day.
Electronic cigarette (nicotine/placebo) - Days 7 through 8 Electronic cigarette exposure will be limited to two days
Electronic cigarette (nicotine/placebo) - Days 6 through 8 Electronic cigarette exposure will be limited to 3 days
Electronic cigarette (nicotine/placebo) - Days 5 through 8 Electronic cigarette exposure will be limited to 4 days
Electronic cigarette (nicotine/placebo) - Days 4 through 8 Electronic cigarette exposure will be limited to 5 days.