Effects of Endotoxin in Normal Human Volunteers
Healthy, Lung Disease, Sepsis
About this trial
This is an interventional treatment trial for Healthy focused on measuring Hemodynamics, Lung Permeability, Endotoxin Tolerance, Bronchoscopy, Human Recombinant Interleukin-1 Receptor, Normal Volunteer
Eligibility Criteria
INCLUSION CRITERIA: 18 to 45 years of age, either male or female Employees or non-employees are eligible Normal screening examination: history and physical examination, nonsmoker, no concurrent medications including aspirin or nonsteroidal anti-inflammatory drugs, no active medical problems; complete blood count with differential and platelet counts; serum chemistries including creatinine, blood urea nitrogen, glucose, liver enzymes and function tests, electrolytes, prothrombin time, partial thromboplastin time; urinalysis; female subjects must have negative urine pregnancy test within one week of participation; electrocardiogram; chest radiograph. If age is 40 to 45 years, normal submaximal stress test to screen for asymptomatic coronary artery disease. EXCLUSION CRITERIA: Pregnancy. Lactation. History of recent clinically significant asthma. Subjects who have an allergy to both sulfa- and penicillin-based drugs will not be eligible for the endotoxin instillation portion of the study.
Sites / Locations
- National Institutes of Health Clinical Center, 9000 Rockville Pike