Effects of Enhancers and Inhibitors on Absorption From Iron Supplements
Iron-deficiency, Iron Deficiency Anemia
About this trial
This is an interventional treatment trial for Iron-deficiency focused on measuring iron supplementation, women of reproductive age, iron absorption enhancers, iron absorption inhibitors, ferrous fumarate, iron deficiency
Eligibility Criteria
Inclusion Criteria:
- Female, 18 to 45 years old,
- SF levels <30 μg/L,
- Body weight < 70 kg
- Normal Body Mass Index (18.5-25 kg/m2),
- Signed informed consent.
Exclusion Criteria:
- Anemia (Hb < 12 g/dL)
- Elevated CRP > 5 mg/L,
- Any metabolic, gastrointestinal, kidney or chronic disease such as diabetes, renal failure, hepatic dysfunction, hepatitis, hypertension, cancer or cardiovascular diseases (according to the participants own statement) affecting iron metabolism,
- Continuous/long-term use of medication during the whole study, which may interfere with iron absorption, gut physiology and iron metabolism,
- Consumption of mineral and vitamin supplements since screening and over the study period until last blood sample collection,
- Difficulties with blood sampling,
- Blood transfusion, blood donation or significant blood loss (accident, surgery) over the past 6 months,
- Known hypersensitivity or allergy to iron capsules in the given amount (ferrous fumarate, brilliant blue FCF (E133), titandioxide (E171) and sodium lauryl sulfate)
- Pregnancy, breastfeeding
- Women who intend to become pregnant during the course of the study,
- Known or suspected non-compliance, drug or alcohol (more than 2 drinks/day) abuse,
- Smokers (> 1 cigarette per week),
- Participant is likely to be absent on one the study appointments,
- Inability to follow the procedures of the study, e.g. due to language problems, self-reported psychological disorders, etc. of the participant.
Sites / Locations
- ETH Zurich; Human Nutrition Laboratory; Institute of Food, Nutrition and Health
Arms of the Study
Arm 1
Arm 2
Arm 3
Arm 4
Arm 5
Arm 6
Active Comparator
Experimental
Experimental
Experimental
Experimental
Experimental
Reference
Ascorbic acid (AA) 500 mg
Ascorbic acid (AA) 80 mg
Coffee
Breakfast
Afternoon
Ferrum Hausmann 100 mg is consumed with 200 mL nanopure water with labelled ferrous fumarate (3 mg 54Fe).
Ferrum Hausmann 100 mg is consumed with 200 mL nanopure water with labelled ferrous fumarate (3 mg 57Fe) and 500 mg AA.
Ferrum Hausmann 100 mg is consumed with 200 mL nanopure water with labelled ferrous fumarate (3 mg 58Fe) and 80 mg AA.
Ferrum Hausmann 100 mg is consumed with 200 mL nanopure water with labelled ferrous fumarate (3 mg 54Fe) and 150 mL coffee.
Ferrum Hausmann 100 mg is consumed with 200 mL nanopure water with labelled ferrous fumarate (3 mg 57Fe) and 1 bread roll (~100 g) with butter and honey, 1 cup of plain yoghurt (180 mL), 1 cup of coffee (150 mL) and 1 glass of orange juice (250 mL).
Ferrum Hausmann 100 mg is consumed with 200 mL nanopure water with labelled ferrous fumarate (3 mg 58Fe) in the afternoon .