Effects of Fasting Strategies on Postoperative Recovery and Long-term Prognosis in Patients With Colorectal Cancer
Fasting, Immune Suppression, Complication of Surgical Procedure
About this trial
This is an interventional treatment trial for Fasting focused on measuring Fasting, Immune Suppression, Survival, Immune metabolism
Eligibility Criteria
Inclusion Criteria:
- Age 20 ~ 70 years old
- With BMI 20.5-25.0 kg/m2
- Without any Endocrine and metabolic diseases
- A stable body weight (±3 kg) for at least 6 months
- Those diagnosed with colorectal cancer by preoperative pathology or enteroscopy
- Patients undergoing laparoscopic radical colorectal cancer resection
- ASA grade I-III grade
- Initial patients have not received any treatment for bowel cancer except neoadjuvant chemotherapy
- Patients with confirmed and feasible radical resection of colorectal cancer
- No evidence of distant metastasis before surgery
- Willing to participate in the research of the subject and agree to follow up regularly
Exclusion Criteria:
- Patients with relapsed colorectal cancer who are going to undergo surgery and re-excision
- accompanied by other malignant tumors
- Severe malnourished patients
- History of systemic metabolism such as diabetes
- Before surgery, have received other treatments for colorectal cancer (such as local excision, etc.) in addition to neoadjuvant chemotherapy
- Have a history of immunotherapy before surgery
- Combined with basic diseases of serious heart, lung, brain, kidney and other important organs
- Combined with severe primary diseases such as severe immune system or hematopoietic system
- The tumor burden cannot be cured, and there is distant metastasis. Those who intend to undergo palliative surgery
- People with gastroesophageal reflux disease, difficulty swallowing, intestinal obstruction, or difficulty in airway management
- People who refuse to participate in the study or cannot receive long-term follow-up
Sites / Locations
- Department of Biostatistics, School of Public Health, Fudan University,
- Fudan University Huashan Hospital
- Fudan University Shanghai Cancer center
- Fudan University,ZhongShan Hospital
- Shanghai Changhai Hospital, Naval Medical University,
- Shanghai First People's Hospital,Shanghai Jiaotong University
- Shanghai Tongji Hospital,Tongji University
Arms of the Study
Arm 1
Arm 2
Placebo Comparator
Experimental
Normal Fasting
Prolong Fasting
The patient starts fasting 8 hours before the operation,and does not take any solid or liquid foods and nutrients during the fasting process.The fasting period does not strictly limit the consumption of pure water,After surgery 8 hours,the patients was allowed to feeding.
The patient starts fasting 24 hours before the operation, and does not take any solid or liquid foods and nutrients during the fasting process. The fasting period does not strictly limit the consumption of pure water.After surgery 24 hours,the patients was allowed to feeding.