Effects of Galantamine on Cognition
Schizophrenia
About this trial
This is an interventional prevention trial for Schizophrenia focused on measuring Galantamine, Schizophrenia, working memory, cognitive
Eligibility Criteria
Inclusion Criteria:
- age range of 18-64 (confirmed by drivers license or other form of identification)
- the presence of 3 or more SSP symptoms (at least 2 of the SSP symptoms will be negative symptoms as defined by the schizoid traits)
- the presence of visuospatial working memory impairment as defined by error in the oculomotor delayed response (ODR) task of more than 0.5 SD above the mean values in healthy control subjects
- relative of an individual with schizophrenia, schizoaffective disorder, or schizophreniform disorder
- able to provide written informed consent (ESC score 10 or above)
Exclusion Criteria:
- subjects meeting criteria for a life-time diagnosis of any one of the DSM IV, Axis I psychotic disorders (exceptions being a single past episode of major depressive disorder with psychotic features or psychotic symptoms associated with substance abuse with the substance abuse ending 6-months prior to study participation) (this is for the SSP recruitment)
- subjects meeting DSM-IV criteria for current alcohol or substance dependence (other than nicotine) within the last 6 months or DSM-IV criteria for alcohol or substance abuse (other than nicotine) within the last month
- medical conditions that preclude participation in drug trials or assessments of outcome measures (including significant brain, cardiac, liver, lung, endocrinological or metabolic disorders)
- received any investigational drug in the preceding four weeks
- pregnant or of childbearing age and not using a medically approved form of birth control
Sites / Locations
- University of Maryland, Baltimore
Arms of the Study
Arm 1
Arm 2
Experimental
Experimental
Galantamine, then Placebo
Placebo, then Galantamine
Participants took lead-in 3 days of 4mg/ twice a day of galantamine followed by 8 mg on the 4th day, the day of testing. Then, after a period of at least one month, participants took lead-in 3 days of 4mg/ twice a day of placebo followed by 8 mg on the 4th day, the day of testing.
Participants took lead-in 3 days of 4mg/ twice a day of placebo followed by 8 mg on the 4th day, the day of testing. Then, after a period of at least one month, participants took lead-in 3 days of 4mg/ twice a day of galantamine followed by 8 mg on the 4th day, the day of testing.